Results 131 to 140 of about 2,788,838 (297)
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
On the existence of solutions of the differential equation with advanced argument [PDF]
, 1985 In this paper the differential-functional equationϕ\u27(t) = f(t,ϕ), t∈R+ϕ(0) = ηwith an unbounded advanced argument is discovered. Under suitable assumptions, using Schauder Fixed Point Principle, a theorem on existence of solutions in a special ...
Muzyczka, Zofia
core
On the random integral equation with advancing argument
, 2020 The author proves existence and uniqueness of a random solution of the equation \[ x(\omega,t)=-y(\omega,t)+\int^{t+\delta (t)}_{0}K(\omega,u,x(\omega,u))du \] under certain continuity conditions for y, K and \(\delta\) and growth conditions on y and K. The main tool is an application of Banach's fixed point theorem.
openaire +3 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Electronic Journal of Differential Equations, 2002 We study the oscillation of solutions to the differential equation $$ dot{x}(t) +a_1(t)x[r(t)]+a_2(t)x[p(t)]=0, quad tgeq t_0 $$ which has a retarded argument $r(t)$ and an advanced argument $p(t)$.
Leonid Berezansky, Yury Domshlak
doaj
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Political Decision-making, Lottocracy, and AI
Conatus - Journal of PhilosophyThis article examines an argument for single-issue legislatures (SILs) as an alternative to typical decision-making procedures in representative democracies.
Joe Slater
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
ManuscritoAt the core of Kant’s theoretical philosophy lies the deduction of the categories: his effort to secure the distinctiveness of sensibility and understanding and to provide a necessary relation between the domains of these faculties. The argument for this
Adriano Perin
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source