Results 121 to 130 of about 2,788,838 (297)
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
The Doomsday Argument in Many Worlds [PDF]
, 2012 You and I are highly unlikely to exist in a civilization that has produced only 70 billion people, yet we find ourselves in just such a civilization.
Austin Gerig, Gerig, Austin
core
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Genitives, relational nouns, and the argument-modifier distinction [PDF]
, 2013 The argument-modifier distinction is less clear in NPs than in VPs; nouns do not typically take arguments. The clearest cases of arguments in NPs are in certain kinds of nominalizations which retain some "verbal" properties (Grimshaw 1990). The status of
Partee, Barbara H., Borschev, Vladimir
core
On the Growth of Nonoscillatory Solutions for Difference Equations with Deviating Argument
Advances in Difference Equations, 2008 The half-linear difference equations with the deviating argument Δ(an|Δxn|αsgn Δxn)+bn|xn+q|αsgn xn+q=0 , q ∈ ℤ are considered.
M. Marini +2 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Syntax-driven argument identification and multi-argument classification for semantic role labeling [PDF]
, 2007 Semantic role labeling is an important stage in systems for Natural Language Understanding. The basic problem is one of identifying who did what to whom for each predicate in a sentence. Thus labeling is a two-step process: identify constituent phrases
Lin, Chi-San Althon
core
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source