Results 161 to 170 of about 187,354 (214)

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources

Peripheral endocrine-nutritional machine learning signature predicts short-term response to neoadjuvant immunochemotherapy in locally advanced gastric cancer. [PDF]

Front Immunol
Li F, Mu Z, Guo H, Zheng T, Yang P, Wang Z, Shi Y, Xu W, Tian Y, Ma W, Zhao Q.   +10 more
europepmc   +1 more source

Refining OVCAR‐3 xenograft models of peritoneal carcinomatosis in nu/nu mice: Comparative intraperitoneal implantation strategies and the role of basement membrane matrix

Animal Models and Experimental Medicine, EarlyView.
A refined murine model of advanced ovarian cancer was established by comparing localized preperitoneal implantation and intraperitoneal injection of OVCAR‐3Luc cells. While localized implantation showed limited tumor persistence, intraperitoneal delivery with BME produced sustained diffuse dissemination confirmed by BLI and histology, providing a ...
M. Teresa Perelló‐Trias, Antonio Jose Serrano‐Muñoz, Juan J. Segura‐Sampedro, Adriana M. Quintero‐Duarte, Joana M. Ramis, Marta Monjo   +5 more
wiley   +1 more source

Metabolic syndrome as an independent predictor of response and survival in locally advanced gastric cancer treated with neoadjuvant immunochemotherapy. [PDF]

Front Oncol
Li F, Guo H, Wu J, Wu H, Wang Z, Li X, Guo Z, Tian Y, Yang Y, Ma S, Ma W, Zhao Q.   +11 more
europepmc   +1 more source

Developing a strain‐dependent susceptibility to hepatocellular carcinoma in a murine model based on histopathological evidence and genetic context

Animal Models and Experimental Medicine, EarlyView.
Using F1 (C57BL/6J/Smad4+/− X CC) mice, we found that partial loss of Smad4 promotes liver carcinogenesis in a strain‐dependent manner, highlighting the importance of genetic modifiers in tumor susceptibility. The use of Collaborative Cross mice provides a valuable platform for uncovering genotype‐specific cancer susceptibilities in preclinical ...
Osayd Zohud, Aysar Nashef, Imad Abu‐Elnaaj, Fuad A. Iraqi   +3 more
wiley   +1 more source

Readministration of nivolumab for patients with advanced gastric cancer: a case series. [PDF]

ESMO Gastrointest Oncol
Kodama H, Narita Y, Honda K, Masuishi T, Taniguchi H, Kadowaki S, Ando M, Tajika M, Yamaguchi T, Nishikawa H, Muro K.   +10 more
europepmc   +1 more source

Nanofabricated Biomaterials Model Tumor Extracellular Matrix Topography

Advanced NanoBiomed Research, EarlyView.
The unique structure and composition of the tumor microenvironment and its associated extracellular matrix (ECM) exert profound effects on cancer cell behavior that are difficult to model in vitro. This perspective discusses the utility of nanofabricated biosubstrates, such as the novel collagen‐coated nanogrooved array, for recapitulating the ...
Vic Zamloot, JinSeok Park
wiley   +1 more source

Efficacy and safety of antibody-drug conjugates in HER2-positive and HER2-low advanced gastric cancer: a systematic review and update. [PDF]

J Egypt Natl Canc Inst
Lei L, Hu K, Xie S, Dong B, Rong Z, Pang X, Zhang J, Zhou Y.   +7 more
europepmc   +1 more source

Efficacy hierarchy and absolute survival benefit of first-line immunotherapy in advanced gastric cancer: a meta-analysis and pooled survival analysis. [PDF]

Front Immunol
Lv J, Thangaretnam K, Islam MO, Tang J, Denize S, Bhat N, Zhu S, Lu H, Peng D, El-Rifai W, Chen Z.   +10 more
europepmc   +1 more source