Results 51 to 60 of about 49,140 (359)

Encapsulation of ascorbic acid promotes the reduction of Maillard reaction products in UHT milk [PDF]

, 2016
The presence of amino groups and carbonyls renders fortified milk with ascorbic acid particularly susceptible to the reduction of available lysine and to the formation of Maillard reaction products (MRPs), as Nε-(Carboxyethyl)-L-lysine (CEL), Nε ...
Ahmed, Castro, Clegg, Dunn, Erbersdobler, Fan, Fenoll, Fiore, Hasenkopf, Hellwig, Henning, Hernandez, Kurata, Larisch, Leclère, Lee, Limacher, Limacher, Manso, Nashalian, Nguyen, Nursten, Perez Locas, Schulz, Singh, Smuda, Smuda, Smuda, Teucher, Troise, Troise, Troise, Uddin, van Boekel, Vitaglione, Yaylayan, Özdemir   +36 more
core   +5 more sources

Advanced Glycation End Product Accumulation in Subjects with Open-Angle Glaucoma with and without Exfoliation

Antioxidants, 2020
Advanced glycation end products (AGEs), which are the products of a non-enzymatic reaction between reducing sugars and other macromolecules, are critical in aging, as well as metabolic and degenerative diseases.
Tomoki Shirakami, Mikihiro Yamanaka, Jo Fujihara, Yotaro Matsuoka, Yuko Gohto, Akira Obana, Masaki Tanito   +6 more
doaj   +1 more source

Modulation of the glyoxalase system in the aging model Podospora anserina : effects on growth and lifespan [PDF]

, 2010
The eukaryotic glyoxalase system consists of two enzymatic components, glyoxalase I (lactoylglutathionelyase) and glyoxalase II (hydroxyacylglutathione hydrolase). These enzymes are dedicated to the removal of toxic alpha-oxoaldehydes like methylglyoxal (
Gispert, Suzana, Mack, Sandra J., Osiewacz, Heinz D., Ricciardi, Filomena, Scheckhuber, Christian Q., Strobel, Ingmar   +5 more
core   +2 more sources

Age-dependent changes in plasma amino acids contribute to alterations in glycoxidation products [PDF]

Journal of Medical Biochemistry, 2018
Background: Glycative stress is involved in the pathogenesis of various degenerative disorders. This study sought to determine the effect of age-related changes in amino acids on serum levels of pentosidine and carboxymethyl-lysine (CML) in healthy ...
Foroumandi Elaheh, Alizadeh Mohammad, Kheirouri Sorayya   +2 more
doaj  

Blockade of advanced glycation end product formation attenuates bleomycin-induced pulmonary fibrosis in rats

Respiratory Research, 2009
Background Advanced glycation end products (AGEs) have been proposed to be involved in pulmonary fibrosis, but its role in this process has not been fully understood.
Liu Dai-Shun, Li Ji-Qiong, Sun Bei-Bei, Wang Xun, Wang Tao, Chen Lei, Zhang Shang-Fu, Liu Lin, Xu Dan, Chen Ya-Juan, Wen Fu-Qiang   +10 more
doaj   +1 more source

PDGF-BB does not accelerate healing in diabetic mice with splinted skin wounds. [PDF]

, 2014
Topical application of platelet-derived growth factor-BB (PDGF-BB) is considered to accelerate tissue repair of impaired chronic wounds. However, the vast literature is plagued with conflicting reports of its efficacy in animal models and this is often ...
Abbott, Nicholas, Covert, Jill, Dubielzig, Richard, Isseroff, Roslyn, McAnulty, Jonathan, Motta, Monica, Murphy, Christopher, Park, Shin, Raghunathan, Vijay, Schurr, Michael, Shah, Nihar, Teixeira, Leandro   +11 more
core   +2 more sources

Bone Healing Around Implants in Normal and Medically Compromised Conditions: Osteoporosis and Diabetes

Advanced Healthcare Materials, EarlyView.
xx xx. ABSTRACT Osseointegration of orthopedic and dental implants is influenced by local and systemic factors, including their physicochemical surface properties and the patient's overall health status. Titanium and its alloys have been a longstanding standard for bone implants due to their innate biocompatibility and mechanical properties.
Dainelys Guadarrama Bello, Fabio Variola, Antonio Nanci   +2 more
wiley   +1 more source

DJ-1 as a deglycating enzyme: A unique function to explain a multifaceted protein? [PDF]

, 2017
The recently reported deglycating activity of DJ-1 reconciles several features previously described for the protein. The deglycating activity reported for DJ-1 may explain its different subcellular localizations, indeed the protein has been found in the ...
Bisaglia, Marco, DE LAZZARI, Federica
core   +2 more sources

Advanced Glycation End Products in Clinical Nephrology

Kidney and Blood Pressure Research, 2004
As a result of oxidative and carbonyl stress, advanced glycation end products (AGEs) are involved in the pathogenesis of severe and frequent diseases and their fatal vascular/cardiovascular complications, i.e. diabetes mellitus and its complications (nephropathy, angiopathy, neuropathy and retinopathy, renal failure and uremic and dialysis-associated ...
M, Kalousová, T, Zima, V, Tesar, S, Stípek, S, Sulková   +4 more
openaire   +2 more sources

Hyperviscous Diabetic Bone Marrow Niche Impairs BMSCs Osteogenesis via TRPV2‐Mediated Cytoskeletal‐Nuclear Mechanotransduction

Advanced Science, EarlyView.
Diabetic bone marrow exhibits pathological ECM hyperviscosity that activates TRPV2‐mediated Ca2⁺ influx, leading to perinuclear F‐actin disassembly, nuclear deformation, and chromatin condensation. This cytoskeletal‐nuclear decoupling suppresses osteogenic differentiation of BMSCs.
Yao Wen, Xinhui Zheng, Jieliu Li, Minyu He, Dongqi Fan, Xingyu Zhu, Qiming Zhai, Liangjing Xin, Tao Chen   +8 more
wiley   +1 more source