Results 141 to 150 of about 288,435 (354)

The serum metabolome serves as a diagnostic biomarker and discriminates patients with melanoma from healthy individuals

Cell Reports Medicine
Summary: Melanoma is a deadly cancer with increasing incidence and mortality rates, and biomarkers for diagnosis are urgently needed. The impact of the microbiome, genetic factors, and immunologic markers on disease outcomes is described, but a ...
Yasser Morsy, Barbara Hubeli, Patrick Turko, Marjam Barysch, Julia M. Martínez-Gómez, Nicola Zamboni, Gerhard Rogler, Reinhard Dummer, Mitchell P. Levesque, Michael Scharl   +9 more
doaj   +1 more source

APOBEC-related mutagenesis and neo-peptide hydrophobicity: implications for response to immunotherapy. [PDF]

, 2019
Tumor-associated neo-antigens are mutated peptides that allow the immune system to recognize the affected cell as foreign. Cells carrying excessive mutation load often develop mechanisms of tolerance.
Boichard, Amélie, Frampton, Garrett M, Goodman, Aaron, Kurzrock, Razelle, Lippman, Scott, Pham, Timothy V, Tamayo, Pablo, Tsigelny, Igor F, Yeerna, Huwate   +8 more
core  

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

Advanced stage melanoma during pregnancy: recommendations from a retrospective, multicentre, registry-based studyResearch in context

EClinicalMedicine
Summary: Background: Diagnosis and treatment of advanced melanoma during pregnancy represents a major challenge, with scarce data on outcome or management available. Therefore, the Melanoma Pregnancy Taskforce collected real-world data to understand the
Jessica S.W. Borgers, Douglas B. Johnson, Elisabeth Livingstone, Dirk Schadendorf, Elizabeth I. Buchbinder, Lauren E. Haydu, Laura Gohil, William A. Robinson, Inderjit Mehmi, Omid Hamid, Michelle Ferreira, April K.S. Salama, Florentia Dimitriou, Matteo S. Carlino, Georgina V. Long, Paolo A. Ascierto, Ester Simeone, Yana G. Najjar, Geke A.P. Hospers, Jacob Choi, Sunandana Chandra, Jeffrey D. Wayne, Carlos I.R. García, Wen Xu, Céleste Lebbé, Laetitia Da-Meda, Victoria Atkinson, Meredith Mckean, Andrea Forschner, Elliot A. Asare, Antonios Daletzakis, Jolyn S. Taylor, Frédéric Amant, Katy K. Tsai, Zeynep Eroglu, John B.A.G. Haanen, Isabella C. Glitza de Oliva   +36 more
doaj   +1 more source

LNK suppresses interferon signaling in melanoma. [PDF]

, 2019
LNK (SH2B3) is a key negative regulator of JAK-STAT signaling which has been extensively studied in malignant hematopoietic diseases. We found that LNK is significantly elevated in cutaneous melanoma; this elevation is correlated with hyperactive ...
Ding, Ling-Wen, Doan, Ngan, Edwards, Jarem J, Fernández, Lucia Torres, Koeffler, H Phillip, Lin, De-Chen, Loh, Xin-Yi, Mullins, David W, Pein, Maren, Ran, Xue-Bin, Said, Jonathan W, Scolyer, Richard A, Sun, Qiao-Yang, Thompson, John F, Venkatachalam, Nachiyappan, Wilmott, James S, Xiao, Jin-Fen, Xu, Liang, Yang, Henry, Zhou, Si-Qin   +19 more
core  

High‐Throughput In Vivo Screening Using Barcoded mRNA Identifies Lipid Nanoparticles With Extrahepatic Tropism for In Situ Immunoengineering

Advanced Materials, EarlyView.
A high‐throughput in vivo mRNA LNP screening platform is developed and employed to screen a large library of 122 mRNA LNPs in vivo for delivery to immune, stromal, and parenchymal cells, identifying promising LNP candidates. A novel small particle flow cytometry‐based protein adsorption analysis method is utilized to interrogate protein corona ...
Alex G. Hamilton, Ajay S. Thatte, Junchao Xu, Zhangyi Luo, Hannah C. Safford, Kelsey L. Swingle, Jenna Muscat‐Rivera, Michael Kegel, Xuexiang Han, Ryann A. Joseph, Amanda M. Murray, Hannah C. Geisler, Ricardo C. Whitaker, Lulu Xue, Roman Spektor, Jilian R. Melamed, Drew Weissman, Michael J. Mitchell   +17 more
wiley   +1 more source

Immunological effects of BRAF+MEK inhibition

OncoImmunology, 2018
Recent developments in immunotherapy have prolonged overall survival in metastatic melanoma with the possibility to reach a long-term benefit. Targeted therapies based on BRAF and MEK inhibition also seem to have a long-term beneficial effect, which is ...
Paolo A. Ascierto, Reinhard Dummer
doaj   +1 more source

Metamaterial Antennas Enhance MRI of the Eye and Occipital Brain

Advanced Materials, EarlyView.
A radiofrequency antenna platform comprising planar and bend configurations is developed, incorporating structurally integrated epsilon‐negative metamaterial unit cells to enhance MRI. These antennas enable high‐resolution in vivo human MRI of the eye, orbit, and occipital brain. Comprehensive validation, including simulations, phantom experiments, SAR,
Nandita Saha, Bilguun Nurzed, Mostafa Berangi, Andre Kuehne, Helmar Waiczies, Igor Fabian Tellez Ceja, Xiang Hu, Thomas Gladytz, Lisa Krenz, Dave Huebler, Beate Endemann, Claudia Brockmann, Ebba Beller, Oliver Stachs, Thoralf Niendorf   +14 more
wiley   +1 more source

Emerging options for the treatment of melanoma – focus on ipilimumab

ImmunoTargets and Therapy, 2014
Claire Roddie, Karl S Peggs UCL Cancer Institute, Department of Hematology, London, UK Abstract: Ipilimumab is a fully human immunoglobulin subclass G1 anticytotoxic-T-lymphocyte-antigen-4 monoclonal antibody.
Roddie C, Peggs KS
doaj  

Targeted therapy or immunotherapy in BRAF-mutated metastatic melanoma: a Spanish center’s decade of experience

Frontiers in Oncology
BackgroundTargeted therapies and immunotherapy are currently considered the mainstay first-line treatment for advanced BRAF-mutated melanoma. However, the impact of treatment (targeted therapy and immunotherapy) and the prognostic factors are still not ...
Chen Sun, Sofia España, Nina Richarz, Carme Solé-Blanch, Aram Boada, Anna Martinez-Cardús, Alan Chu, Zongwen Liu, Jose Luis Manzano   +8 more
doaj   +1 more source