Results 131 to 140 of about 184,433 (313)

Immunological effects of BRAF+MEK inhibition

OncoImmunology, 2018
Recent developments in immunotherapy have prolonged overall survival in metastatic melanoma with the possibility to reach a long-term benefit. Targeted therapies based on BRAF and MEK inhibition also seem to have a long-term beneficial effect, which is ...
Paolo A. Ascierto, Reinhard Dummer
doaj   +1 more source

Advances in systemic treatment of melanoma

Annals of Oncology, 2010
After decades of phase III trials failing to demonstrate an impact on survival of various drugs in metastatic melanoma there are finally significant advances in systemic therapies for melanoma emerging. Novel ways to modulate the immune system by monoclonal antibodies as well as various signalling pathway inhibitors are responsible for creating a whole
openaire   +2 more sources

Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+‐Dependent Endoplasmic Reticulum Stress in Distal Tubules

Advanced Science, EarlyView.
In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang, Xin He, Hao Huang, Rong Lu, Xin Lv, Shenglan Li, Sijue Zou, Jiawei Cheng, Yiwei Xiong, Zhenghao Deng, Qiongjing Yuan, Yanyun Xie, Ling Huang, Jiaxi Pu, Shao Liu, Qianbin Li, Jie Meng, Huixiang Yang, Lijian Tao, Zhangzhe Peng   +19 more
wiley   +1 more source

Clinical significance of serum M30 and M65 levels in melanoma

, 2013
M30 and M65 are relatively new assays that detect different circulating forms of the epithelial cell structural protein cytokeratin 18. This study was carried out to investigate the serum levels of M30 and M65 in patients with melanoma and the ...
Tas, Faruk, Serilmez, Murat, Yildiz, Ibrahim, Karabulut, Senem, Duranyildiz, Derya, Ciftci, Rumeysa, Sen, Fatma   +6 more
core   +1 more source

The serum metabolome serves as a diagnostic biomarker and discriminates patients with melanoma from healthy individuals

Cell Reports Medicine
Summary: Melanoma is a deadly cancer with increasing incidence and mortality rates, and biomarkers for diagnosis are urgently needed. The impact of the microbiome, genetic factors, and immunologic markers on disease outcomes is described, but a ...
Yasser Morsy, Barbara Hubeli, Patrick Turko, Marjam Barysch, Julia M. Martínez-Gómez, Nicola Zamboni, Gerhard Rogler, Reinhard Dummer, Mitchell P. Levesque, Michael Scharl   +9 more
doaj   +1 more source

Mechanism‐Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy

Advanced Science, EarlyView.
MISPOP integrates ensemble learning with membrane‐active physicochemical priors to identify Dermaseptin‐S9, a natural oncolytic peptide that disrupts tumor membranes, triggers immunogenic cell death, and shows strong antitumor activity. The study illustrates a mechanism‐informed route from peptide sequence data to cancer immunotherapy leads.
Wen Zhang, Shengxin Lu, Guangyong Zheng, Shensuo Li, Hongyu Chen, Mei Hong, Xiangru Zhou, Ruotian Tang, Ye Wu, Weidong Zhang, Dong Lu, Xin Luan   +11 more
wiley   +1 more source

Topoisomerase I Amplification in Melanoma is Associated with More Advanced Tumours and Poor Prognosis

, 2010
Summary In this study, we used array-comparative genomic hybridisation (aCGH) and fluorescent in situ hybridisation (FISH) to examine genetic aberrations in melanoma cell lines and tissues.
Dervan, Peter A., Bergqvist, Michael, Strömberg, Sara, O'Leary, Patrick, Dervan, Peter A, Kampf, Caroline,, Hegarty, Shauna, Pontén, Fredrik, Agnarsdottir, Margret,, O´Leary, Patrick, Faller, William, Pontén, Fredrik,, Strömberg, Sara,, Gallagher, William M, Rafferty, Mairin, Kampf, Caroline, Ryan, Denise, Agnarsdottir, Margret, Gallagher, William M., Bergqvist, Michael,, Gremel, Gabriela, Millikan, Robert C, Millikan, Robert C.   +22 more
core   +1 more source

Advanced stage melanoma during pregnancy: recommendations from a retrospective, multicentre, registry-based studyResearch in context

EClinicalMedicine
Summary: Background: Diagnosis and treatment of advanced melanoma during pregnancy represents a major challenge, with scarce data on outcome or management available. Therefore, the Melanoma Pregnancy Taskforce collected real-world data to understand the
Jessica S.W. Borgers, Douglas B. Johnson, Elisabeth Livingstone, Dirk Schadendorf, Elizabeth I. Buchbinder, Lauren E. Haydu, Laura Gohil, William A. Robinson, Inderjit Mehmi, Omid Hamid, Michelle Ferreira, April K.S. Salama, Florentia Dimitriou, Matteo S. Carlino, Georgina V. Long, Paolo A. Ascierto, Ester Simeone, Yana G. Najjar, Geke A.P. Hospers, Jacob Choi, Sunandana Chandra, Jeffrey D. Wayne, Carlos I.R. García, Wen Xu, Céleste Lebbé, Laetitia Da-Meda, Victoria Atkinson, Meredith Mckean, Andrea Forschner, Elliot A. Asare, Antonios Daletzakis, Jolyn S. Taylor, Frédéric Amant, Katy K. Tsai, Zeynep Eroglu, John B.A.G. Haanen, Isabella C. Glitza de Oliva   +36 more
doaj   +1 more source

Triple‐Negative Breast Cancer Cells Utilize IL8 and CXCL1 to Suppress NK Cells’ Function and Facilitate Cancer Metastasis

Advanced Science, EarlyView.
Triple‐negative breast cancer (TNBC) cells evade natural killer (NK) cell immunity by secreting IL8 and CXCL1. These chemokines suppress NK cells’ function via CXCR1/2 and enhance cancer cells’ survival through PD‐L1 upregulation and BCL‐2 anti‐apoptotic signaling.
Mingheng Yuan, Hongmei Yang, Renfei Wu, Meng Hao, Xiangpeng Chu, Chuxia Deng, Kathy Qian Luo   +6 more
wiley   +1 more source

Clinical utility of nivolumab in the treatment of advanced melanoma

, 2016
Ramsey Asmar,1 Jessica Yang,1 Richard D Carvajal1,2 1Department of Medicine, College of Physicians and Surgeons, 2Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA Abstract: Melanomas are highly immunogenic tumors that ...
Yang J, Carvajal RD, Asmar R
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