Results 111 to 120 of about 184,433 (313)
, 2016 M.S.S. is funded by grants from the Spanish Ministry of Economy and Innovation (projects SAF2011-28317, SAF2014-56868-R and RTC-2014-2442-1), as well as a Team Science Award by the Melanoma Research Alliance, and grants from the Worldwide Cancer Research
Cifdaloz, Metehan +10 more
core +1 more source
Recent Advances in Melanoma Biology
The Oncologist, 2004 Abstract Learning Objectives After completing this course, the reader will be able to: Identify the epidemiological evidence supporting the association of intermittent sun exposure with melanoma. Discuss the role of cell adhesion molecules in melanoma progression.
Cliff, Perlis, Meenhard, Herlyn
openaire +2 more sources
A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity
Advanced Science, EarlyView.This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu +16 more
wiley +1 more source
Treating advanced melanoma: current insights and opportunities
, 2014 Michael Tronnier, Christina Mitteldorf Department of Dermatology, Klinikum Hildesheim GmbH, Hildesheim, Germany Abstract: Whereas thin melanomas have an excellent prognosis after sufficient surgical treatment, melanoma disease in advanced stages is ...
Mitteldorf C, Tronnier M
core
Human Pathology: Case Reports, 2018 Melanoma of the penis is an uncommon and unfavorable malignant tumor which is diagnosed late due to the psychological impact. We report a case of advanced melanoma of the glans penis in a 30-year-old patient.
Mohamed Kouyaté +7 more
doaj +1 more source
Advanced Science, EarlyView.This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu +18 more
wiley +1 more source
Programmed cell death 1 checkpoint inhibitors in the treatment of patients with advanced melanoma
, 2017 The treatment landscape of advanced melanoma has changed significantly following the discovery and marketing authorisation of immune checkpoints inhibitors. Ipilimumab (anti-CTLA-4) was the first one to be approved, and it.
Andrzej Mackiewicz, Jacek Mackiewicz
core +1 more source
Advanced Science, EarlyView.This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou +12 more
wiley +1 more source
Advances and perspectives in immunotherapy of melanoma
Annals of Oncology, 2012 Immunotherapy using unspecific modulators has a long tradition in the adjuvant treatment of stage II/III melanoma. Interferon has shown a consistent effect on relapse-free survival independent of interferon dosage and duration. The results of the american Joint Committee on Cancer (AJCC) Melanoma Staging Database analysis led to a strict inclusion of ...
Schadendorf, Dirk +3 more
openaire +2 more sources
Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis
Advanced Science, EarlyView.This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun +15 more
wiley +1 more source