Results 101 to 110 of about 184,433 (313)

Prognostic significance of melanoma inhibiting activity levels in malignant melanoma.

, 2001
This analytic (phase II) study aimed to investigate the hypothesis that the decline in serum melanoma-inhibiting activity (MIA) levels following initiation of treatment might have prognostic value. The mean serum lactate dehydrogenase (LDH), MIA and S100
Tas, Faruk, DURANYILDIZ, Hadiye Derya, Dalay, N, Yasasever, V, Meral, R, Kurul, S, Camlica, H, Duranyildiz, D   +7 more
core   +1 more source

Serum 5-S-cysteinyl-dopa levels as a predictive marker for the efficacy of nivolumab in advanced malignant melanoma

The International Journal of Biological Markers, 2019
Purpose: With the recent developments in novel molecular targeted therapy such as immune-checkpoint blockades, serine/threonine-protein kinase B-Raf, and mitogen-activated protein kinase kinase inhibitors, the prognosis of advanced malignant melanoma has
Hiroshi Umemura, Tatsuya Kaji, Kota Tachibana, Shin Morizane, Osamu Yamasaki   +4 more
doaj   +1 more source

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

Multicenter, real-life experience with checkpoint inhibitors and targeted therapy agents in advanced melanoma patients in Switzerland [PDF]

, 2017
Metastatic melanoma is a highly aggressive disease. Recent progress in immunotherapy (IT) and targeted therapy (TT) has led to significant improvements in response and survival rates in metastatic melanoma patients.
Mitchell P. Levesque, Michielin, O., Anna L. Frauchiger, Simone M. Goldinger, Held, Ulrike, Held, U., Levesque, Mitchell P, Michielin, Olivier, Joanna Mangana, Goldinger, S.M., Valerie C. Amann, Ralph P. Braun, Ulrike Held, Braun, R.P., Kaufmann, Corina, Viola Stögner, Braun, Ralph P, von Moos, Roger, Corina Kaufmann, Levesque, M.P., Amann, Valerie C, Stögner, Viola, Amann, V.C., Stögner, V., Frauchiger, Anna L, Reinhard Dummer, Cheng, P.F., Mangana, J., Kaufmann, C., Phil F. Cheng, von Moos, R., Frauchiger, A.L., Dummer, R., Dummer, Reinhard, Roger von Moos, Olivier Michielin, Goldinger, Simone M, Cheng, Phil F; https://orcid.org/, Mangana, Joanna   +38 more
core   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Study of circulating MicroRNA-125b levels in serum exosomes in advanced melanoma

, 2014
Context: Malignant melanoma is an aggressive tumor that produces exosomes, which contain microRNAs (miRNAs) that could be of utility in following tumoral cell dysregulation.
Martín-Algarra, Salvador, Carranza, O. (Omar), González, Á. (Álvaro), Rodríguez, C. (Carmen), Rodríguez-Jiménez, Carmen, Alegre, E. (Estibaliz), Sanmamed, Miguel F., Fernandez-Sanmamed, M. (Miguel), Alegre, Estíbaliz, Carranza, Omar, González, Álvaro, Martin-Algarra, S. (Salvador)   +11 more
core   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Association between tumor characteristics and second primary cancers with cutaneous melanoma survival A nationwide cohort study

, 2020
The increased survival in malignant cutaneous melanoma (melanoma) is probably due to early diagnosis combined with improved treatment most recently. National health campaigns and screening programs for melanoma detection were started in Sweden several ...
Försti, Asta,, Hemminki, Akseli,, Hemminki, Kari,, Sundquist, Jan,, Zheng, Guoqiao,, Chattopadhyay, Subhayan,, Sundquist, Kristina,, Lund University.   +7 more
core   +1 more source

Advances in Immunotherapy of Malignant Melanoma [PDF]

Klinicka Onkologie, 2017
Development of immunotherapy has dramatically changed poor prognosis of metastatic malignant melanoma (MM). Inhibition of immune checkpoints represents a new effective treatment. Monoclonal antibodies against CTLA-4 ipilimumab and against PD-1 (programme death 1) nivolumab and pembrolizumab prolong progression free survival and overall survival (OS) in
openaire   +2 more sources

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source