Results 231 to 240 of about 288,435 (354)

A Real-World Evaluation of Clinical Prognostic Scores in Advanced Melanoma Treated with Immune Checkpoint Inhibitors. [PDF]

J Clin Med
Yildiran Keskin GS, Karadurmus N.
europepmc   +1 more source

An open-label, non-randomized, phase IIIb study of trametinib in combination with dabrafenib for patients with unresectable advanced BRAFV600-mutant melanoma: A subgroup analysis of patients with brain metastasis

, 2019
Caroline Dutriaux, Caroline Robert, Jean‐Jacques Grob, Laurent Mortier, O. Dereure, Célèste Lebbé, Sandrine Mansard, Florent Grange, Eve‐Marie Neidhardt, Thierry Lesimple, L. Machet, C. Bédane, H. Maillard, S. Dalac‐Rat, Charlée Nardin, A. Szenik, A. Denden, Philippe Saïag   +17 more
openalex   +1 more source

Supplementary Data from TMB and Inflammatory Gene Expression Associated with Clinical Outcomes following Immunotherapy in Advanced Melanoma

, 2023
F. Stephen Hodi, Jedd D. Wolchok, Dirk Schadendorf, James Larkin, Georgina V. Long, Xiaozhong Qian, Abdel Saci, Tina C. Young, Sujaya Srinivasan, Chang Han, Hao Tang, Megan Wind‐Rotolo, Jasmine I. Rizzo, Donald Jackson, Paolo A. Ascierto   +14 more
openalex   +1 more source

Pirin Transcriptionally Regulates PLA2G4A To Inhibit Ferroptosis in Colorectal Cancer via Lipid Profile Remodeling

Advanced Science, EarlyView.
This study identifies Pirin (PIR), an iron‐binding protein, as a critical ferroptosis suppressor in colorectal cancer through lipid membrane remodeling. PIR, induced by NRF2 during ferroptotic stress, transcriptionally regulates PLA2G4A to shift cellular lipid composition away from ferroptosis‐permissive polyunsaturated phospholipids.
Wei Shi, Yue Qi Ong, Prativa Majee, Esther SM Wong, Amhed Missael Vargas Velazquez, Kerem Fidan, Pierce Kah‐Hoe Chow, Wai Leong Tam, Ker Kan Tan, Iain Beehuat Tan, Vinay Tergaonkar   +10 more
wiley   +1 more source

The somatic affairs of BRAF : tailored therapies for advanced malignant melanoma and orphan non-V600E (V600R-M) mutations

, 2013
Giovanni Ponti, Giovanni Pellacani, Aldo Tomasi, Fabio Gelsomino, Andrea Spallanzani, Roberta Depenni, Samer Al Jalbout, Lisa Simi, Lorella Garagnani, Stefania Borsari, Andrea Conti, Cristel Ruini, Annalisa Fontana, Gabriele Luppi   +13 more
openalex   +2 more sources

USP35 Acts as a Deubiquitinating Enzyme for ID3 to Promote Immune Escape in Colorectal Cancer

Advanced Science, EarlyView.
USP35 stabilizes ID3 expression by deubiquitinating the K2/K30 site, thereby upregulating PD‐L1 and promoting immune escape in colorectal cancer. IU1, an inhibitor of USP35 enzyme activity, has been shown to inhibit USP35, thereby accelerating ID3 degradation, enhancing CD8+ T cell killing, and reversing the immunosuppressive microenvironment ...
Wenxin Chen, Ling Wang, Hongmei Fan, Lisheng Li, Lingyu Zhang, Ruoxin Li, Fang Liu, Fuli Wen, Yunbin Ye, Chuanzhong Huang   +9 more
wiley   +1 more source

Prognostic Biomarkers for Anti-PD-1 Monoclonal Antibodies in the First Line Treatment of Advanced Melanoma. [PDF]

Int J Dermatol
Pásek M, Marques E, Tretera V, Arenberger P, Arenbergerová M, Šilar J, Šulc D.   +6 more
europepmc   +1 more source

Magnetic Resonance Imaging Reveals Meningeal Lymphatic Impairment in Lung Adenocarcinoma Brain Metastasis Progression

Advanced Science, EarlyView.
This study demonstrates meningeal lymphatic impairment associated with lung adenocarcinoma brain metastasis progression in both human patients and mouse models, establishes clinically applicable non‐invasive imaging biomarkers for quantitative analyzing mLV structure and function, and reveals mLVs as robust prognostic indicators and promising potential
Yuan Zhang, Shucheng Jin, Penghui Guo, Yuying Yin, Yichun Hua, Xiaosheng Ding, Zhe Zhang, Shuo Chen, Xu Han, Baowang Li, Yan Liu, Xiaoyan Li, Deling Li, Jing Jing, Wei Shi, Wang Jia   +15 more
wiley   +1 more source

Unraveling Relatlimab-Specific Biology Using Biomarker Analyses in Patients with Advanced Melanoma in RELATIVITY-047. [PDF]

Clin Cancer Res
Lipson EJ, Dolfi S, Tang H, Tawbi HA, Medina-Soto F, Castillo Gutiérrez E, Rutkowski P, Gogas H, Murillo E, Ascierto PA, Desai K, Maio M, Demers K, Mazzei A, Keidel S, Miller-Moslin K, Yu JX, Hodi FS, Schadendorf D, Long GV, Garnett-Benson C.   +20 more
europepmc   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source