Results 51 to 60 of about 288,435 (354)

Association of immune-checkpoint inhibitors and the risk of immune-related colitis among elderly patients with advanced melanoma: real-world evidence from the SEER–Medicare database

Therapeutic Advances in Drug Safety, 2021
Background: The use of anti-cytotoxic T-lymphocyte antigen 4 (anti-CTLA4) therapy (ipilimumab) and anti-programmed cell-death 1 (anti-PD1) agents (nivolumab and pembrolizumab) in advanced melanoma have been associated with immune-related adverse events ...
Abdulaali R. Almutairi, Marion Slack, Brian L. Erstad, Ali McBride, Ivo Abraham   +4 more
doaj   +1 more source

Experiences With Surgical Treatment of Chronic Lower Limb Ulcers at a Tertiary Hospital in Northwestern Tanzania: A Prospective Review of 300 Cases. [PDF]

, 2012
Chronic lower limb ulcers constitute a major public health problem of great important all over the world and contribute significantly to high morbidity and long-term disabilities. There is paucity of information regarding chronic lower limb ulcers in our
Chalya, Phillipo L, Gilyoma, Japhet M, Kidenya, Benson R, Mbunda, Fidelis, McHembe, Mabula D, Mshana, Stephen E, Rambau, Peter   +6 more
core   +3 more sources

Advances in management of melanoma [PDF]

Australian and New Zealand Journal of Medicine, 1999
It is clear from the above that the sentinel node technique and assessment of circulating melanoma cells has provided important additional methods for staging and assessment of prognosis of patients with melanoma. Cure of the disease still depends on good quality surgery and implementation of quality control measures to ensure the adequacy of surgical ...
openaire   +2 more sources

Epigenetic Regulation in Melanoma: Facts and Hopes

Cells, 2021
Cutaneous melanoma is a lethal disease, even when diagnosed in advanced stages. Although recent progress in biology and treatment has dramatically improved survival rates, new therapeutic approaches are still needed.
Emilio Francesco Giunta, Gianluca Arrichiello, Marcello Curvietto, Annalisa Pappalardo, Davide Bosso, Mario Rosanova, Anna Diana, Pasqualina Giordano, Angelica Petrillo, Piera Federico, Teresa Fabozzi, Sara Parola, Vittorio Riccio, Brigitta Mucci, Vito Vanella, Lucia Festino, Bruno Daniele, Paolo Antonio Ascierto, Margaret Ottaviano, On Behalf of SCITO YOUTH   +19 more
doaj   +1 more source

Nivolumab plus ipilimumab in the treatment of advanced melanoma. [PDF]

, 2015
Advanced melanoma has historically been a difficult disease to treat due to few effective systemic treatment options. However, over the past few years, scientific advancements in immune checkpoint inhibition have resulted in several novel approaches that
Daud, Adil I, Tsai, Katy K
core   +1 more source

Phase I Study of Ipilimumab Combined with Whole Brain Radiation Therapy or Radiosurgery for Melanoma Patients with Brain Metastases [PDF]

, 2018
Purpose: We performed a phase I study to determine the maximum tolerable dose (MTD) and safety of ipilimumab with stereotactic radiosurgery (SRS) or whole brain radiotherapy (WBRT) in patients with brain metastases (BM) from melanoma.
Andrews MD, David W., Daskalakis, Constantine, Dicker, Adam, MD, PhD, Eldredge-Hindy, Harriet B., Evans, James J., Farrell, MD, Christopher J, Feeney, Kendra J., Garg, Shivank, Judy, MD, Kevin, Kendra, Kari L., Kim, Lyndon, Kim, MD, Hyun, Liebner, David A., Mastrangelo, Michael, Olencki, Thomas, Palmer, Joshua D., Sato, Takami, Shi, Wenyin, Werner-Wasik, Maria, Williams, Noelle L., Wuthrick, Evan J.   +20 more
core   +2 more sources

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Case report on the role of radiofrequency-assisted spleen-preserving surgery for splenic metastasis in the era of check-point inhibitors. [PDF]

, 2017
RATIONALE: An isolated splenic metastasis is a rare phenomenon noted in advanced stage melanoma. We report the role of radiofrequency (RF) -based splenic-preserving splenectomy in a patient with a solitary splenic metastasis from advanced stage melanoma ...
Aris, Azijli, Bronte, Chakraborty, Chu, Chu, Compérat, Damsky, de Wilt, Delaunay, Foley, Garbe, Genç, Grimaldi, Hashimoto, Hodi, Ito, Koyama, La-Beck, Leone, Liu, Mahoney, Mcgranahan, Márquez-Rodas, Naidoo, Ornellas, Perez-Gracia, Postow, Reccia, Reviews, Shi, Spain, Tas, Theodorou, Wagstaff, Wood, Xu   +36 more
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

PLA1A expression as a diagnostic marker of BRAF-mutant metastasis in melanoma cancer

Scientific Reports, 2021
BRAF and NRAS are the most reported mutations associated to melanomagenesis. The lack of accurate diagnostic markers in response to therapeutic treatment in BRAF/NRAS-driven melanomagenesis is one of the main challenges in melanoma personalized therapy ...
Gang Yang, Shuya Liu, Mazaher Maghsoudloo, Marzieh Dehghan Shasaltaneh, Parham Jabbarzadeh Kaboli, Cuiwei Zhang, Youcai Deng, Hajar Heidari, Maliheh Entezari, ShaoZhi Fu, QingLian Wen, Saber Imani   +11 more
doaj   +1 more source