Results 61 to 70 of about 118,203 (213)

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source

Acute Events in Primary Health Care Settings: An Analysis of Advanced Practice Competencies in Nursing Consultations in Brazil

Nursing Open
Aims To describe nurse practices during acute event nursing consultations in Primary Health Care settings and analyse whether these professionals demonstrate the competencies proposed for Advanced Practice Nurses within a care management scope.
Marília Orlandelli Carrer, Letícia Yamawaka deAlmeida, Andrea Liliana Vesga‐Varela, Daiana Bonfim, Patrícia Aline deAlmeida, Carla Pereira Barreto, Nayara Vilela deFarias Serranegra, Keila Gisele Lima Reis, Claudia Santos Martiniano, Manoel Vieira Miranda Neto   +9 more
doaj   +1 more source

Advanced Nursing Practice in New Zealand: 1998

Nursing Praxis in Aotearoa New Zealand, 1998
In the last decade, change in the health sector has often seemed to deny and thwart the professionalism and expertise of nurses.  However, in the first half of 1998, a number of positive initiatives have come to fruition, which support the development of
Susan Jacobs
doaj   +1 more source

An Expertise Transfer Framework For Autonomous Surgical Assistance

Advanced Science, EarlyView.
This study introduces an expertise transfer framework for procedure‐spanning autonomous surgical assistance. By emulating expert logic through hierarchical perception, attention modeling, and knowledge graph‐based decision‐making, the system provides near‐expert surgical view assistance.
Yuan Gao, Guangdi Chu, Wei Jiao, Yuchuan Zhong, Hang Yuan, Chengjun Li, Jinhua Li, Shuxin Wang, Bo Guan, Jianchang Zhao, Lizhi Pan, Haitao Niu, Jianmin Li   +12 more
wiley   +1 more source

Credentialing: Setting Standards for Advanced Nursing Practice

Nursing Praxis in Aotearoa New Zealand, 2000
While the document Framework, Guidelines and Competencies for Post-Registration Nursing Education (Nursing Council of New Zealand, 1999) provides for approval of programmes preparing nurses for advanced practice, the related credentialing and titling of ...
Susan Jacobs
doaj  

An Adenoviral‐Vectored Tp0326 Vaccine Elicits Robust Functional Antibodies to Prevent Treponema pallidum Dissemination in a Rabbit Model

Advanced Science, EarlyView.
Vaccination promotes cellular infiltration into primary lesions and effectively inhibits T. pallidum dissemination to distal organs. Notably, transfer of lesion tissue from immunized animals fails to establish infection in naive recipients, confirming specific protective immunity.
Yinbo Jiang, Xinyuan Li, Lixia Huang, Xiangcai Zhang, Wujian Ke   +4 more
wiley   +1 more source

Is sports-branded screening effective in identifying adults at greatest risk of developing cardiovascular disease: a convergent parallel mixed-methods design to identify adults at greatest risk of developing cardiovascular disease using an opportunistic sports-branded health screening approach in the community

BMJ Open
Objectives To establish whether sports-branded screening is effective in identifying adults at risk of developing cardiovascular disease (CVD); to determine whether the public would engage with sports-branded health screening and what their experiences ...
Gregory Y H Lip, Deborah Fitzsimmons, James Yates, Paula Carroll, Massirfufulay Kpehe Musa, Ian David Jones, Emma Johnston Smith, Miriam Clowes, Jess Carr, Andrew Fulstow   +9 more
doaj   +1 more source

Structural Variants in the Human Genome Associated With Gut Microbiome and Blood Metabolic Traits With Potential Causal Links

Advanced Science, EarlyView.
Based on a multi‐omics cohort of 2002 individuals comprising high‐depth whole‐genome and metagenomic sequencing data, blood metabolites, and detailed questionnaires, we identified 138 859 high‐confidence SVs, uncovering 36 significant SV–microbiome associations and 48 SV–blood metabolite associations.
Qun Zhou, Keqing Wang, Junhong Chen, Haoyu Wang, Xinjiang Tan, Xuanlin Huang, Zhiyin Lin, Xun Xu, Xin Jin, Shaoqiao Zhang, Liang Xiao, Yuanqiang Zou, Tao Zhang, Xiaomin Liu   +13 more
wiley   +1 more source

PDHA1 Hyperactivation‐Mediated Glucose Metabolism Reprogramming Fuels Neutrophil NETosis and Promotes Acute Lung Injury

Advanced Science, EarlyView.
During NETosis, neutrophils shift metabolically toward enhanced OXPHOS and partially reduced glycolysis. This shift is driven by PDHA1 hyperactivity‐dependent selective metabolic reprogramming. The neutrophil‐targeted nanoparticle 3‑FP‑BSA NPs effectively inhibit NETosis and attenuate ALI.
Yu‐Biao Liu, Wen‐Jing Zhong, Chen‐Yu Zhang, Meng‐Rui Chen, Nan‐Shi‐Yu Yang, Han‐Xi Sha, Yan‐Ling Qiu, Hui Chen, Jin‐Tong Yang, Li‐Ying Liang, Jian‐Bing Xiong, Shao‐Kun Liu, Cha‐Xiang Guan, Jia‐Xi Duan, Yong Zhou   +14 more
wiley   +1 more source

Atlas‐Guided CD55‐Enriched Neutrophil Extracellular Vesicles for Complement–Macrophage Modulation in Diabetic Wounds

Advanced Science, EarlyView.
ABSTRACT Diabetic wounds are characterized by persistent inflammation and impaired immune resolution, yet the therapeutic translation of single‐cell atlases into rational immunomodulatory strategies remains limited. Here, integration of diabetic‐wound single‐cell transcriptomic datasets identifies a neutrophil subpopulation enriched in cluster of ...
Tairong Cui, Jieying Li, Jibing He, Jia Wang, Yun Qian, Yilin Jin, Liuqing Yang, Zaijin Tao, Ziyun Li, Zhengsheng Chen, Wenjing Wang, Xin Ma, Jinglei Wu   +12 more
wiley   +1 more source