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Advances in the Screening and Treatment of Ovarian Cancer [PDF]

Ca-A Cancer Journal for Clinicians, 1992
Ovarian cancer is the leading cause of death from gynecologic malignancies. This article reviews the newer chemotherapeutic agents and treatment strategies available to the practicing clinician. Also discussed are the benefits and shortfalls of the various options for screening, such as ultrasound and tumor markers, as well as the data supporting oral ...
Carolyn D Runowicz
exaly   +3 more sources

Survival and Chemosensitivity in Advanced High Grade Serous Epithelial Ovarian Cancer Patients with and without a BRCA Germline Mutation: More Evidence for Shifting the Paradigm towards Complete Surgical Cytoreduction

Medicina, 2022
Background and Objectives: Approximately 10–15% of high-grade serous ovarian cancer (HGSOC) cases are related to BRCA germline mutations. Better survival rates and increased chemosensitivity are reported in patients with a BRCA 1/2 germline mutation ...
Diederick De Jong, Mohamed Otify, Inga Chen, David Jackson, Kelum Jayasinghe, David Nugent, Amudha Thangavelu, Georgios Theophilou, Alexandros Laios   +8 more
doaj   +1 more source

Impact of proper surgical treatment on the survival of patients with epithelial ovary cancer

Revista do Colégio Brasileiro de Cirurgiões, 2022
Objective: to evaluate the quality of surgical treatment of ovarian cancer patients and assess the impact of adequate surgical oncological treatment on disease-free survival and overall survival of patients with advanced epithelial ovarian cancer ...
FLAVIO HENRIQUE FARIA, ANA PAULA DRUMMOND LAGE, ANGÉLICA NOGUEIRA RODRIGUES, ALBERTO JULIUS ALVES WAINSTEIN   +3 more
doaj   +2 more sources

Prerequisites to improve surgical cytoreduction in FIGO stage III/IV epithelial ovarian cancer and subsequent clinical ramifications

Journal of Ovarian Research, 2023
Background No residual disease (CC 0) following cytoreductive surgery is pivotal for the prognosis of women with advanced stage epithelial ovarian cancer (EOC).
Diederick de Jong, Amudha Thangavelu, Timothy Broadhead, Inga Chen, Dermot Burke, Richard Hutson, Racheal Johnson, Angelika Kaufmann, Peter Lodge, David Nugent, Aaron Quyn, Georgios Theophilou, Alexandros Laios   +12 more
doaj   +1 more source

CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy

Nature Communications, 2021
Several strategies have been attempted to target immune suppressive populations in the tumor microenvironment. Here the authors show that folate receptor β-targeted CAR-T cells eliminate immunosuppressive tumor associated macrophages, promoting ...
Alba Rodriguez-Garcia, Rachel C. Lynn, Mathilde Poussin, Monika A. Eiva, Lauren C. Shaw, Roddy S. O’Connor, Nicholas G. Minutolo, Victoria Casado-Medrano, Gonzalo Lopez, Takami Matsuyama, Daniel J. Powell   +10 more
doaj   +1 more source

Exploration of Peritoneal Metastasis of Advanced Ovarian Cancer and Maintenance Treatment with Traditional Chinese Medicine Based on Theory of Membranous Sanjiao

Zhongliu Fangzhi Yanjiu, 2022
Ovarian cancer has the highest mortality among the three major gynecological malignancies. Peritoneal metastasis, intestinal obstruction and then death is the main outcome pattern of advanced ovarian cancer.
LU Wenping
doaj   +1 more source

Consensus on the management of platinum-sensitive high-grade serous epithelial ovarian cancer in Lebanon

Gynecologic Oncology Reports, 2023
Ovarian cancer is the most lethal gynecologic cancer. The high grade serous epithelial (HGSE) subtype is the most aggressive and it often presents at advanced stages, while screening programs have not proven beneficial. Management of the advanced stages (
Reem Abdallah, David Atallah, Nizar Bitar, Georges Chahine, Hady Ghanem, Marwan Ghosn, Joseph Kattan, Fadi Nasr, Joseph Makdessi, Ali Shamseddine   +9 more
doaj   +1 more source

ITLN1 modulates invasive potential and metabolic reprogramming of ovarian cancer cells in omental microenvironment

Nature Communications, 2020
Advanced ovarian cancer usually spreads to the omentum. Here, the authors show that circulating intelectin-1 (ITLN1) has prognostic significance in patients with advanced ovarian cancer, and that mesothelial cell-derived ITLN1 in the omental tumor ...
Chi-Lam Au-Yeung, Tsz-Lun Yeung, Abhinav Achreja, Hongyun Zhao, Kay-Pong Yip, Suet-Ying Kwan, Michaela Onstad, Jianting Sheng, Ying Zhu, Dodge L. Baluya, Ngai-Na Co, Angela Rynne-Vidal, Rosemarie Schmandt, Matthew L. Anderson, Karen H. Lu, Stephen T. C. Wong, Deepak Nagrath, Samuel C. Mok   +17 more
doaj   +1 more source

Advances in ovarian cancer therapy [PDF]

Cancer Chemotherapy and Pharmacology, 2017
Epithelial ovarian cancer is typically diagnosed at an advanced stage. Current state-of-the-art surgery and chemotherapy result in the high incidence of complete remissions; however, the recurrence rate is also high. For most patients, the disease eventually becomes a continuum of symptom-free periods and recurrence episodes.
Alexander J. Cortez, Patrycja Tudrej, Katarzyna A. Kujawa, Katarzyna M. Lisowska   +3 more
openaire   +2 more sources

Differences in Characteristics and Outcomes Between Large-Cell Neuroendocrine Carcinoma of the Ovary and High-Grade Serous Ovarian Cancer: A Retrospective Observational Cohort Study

Frontiers in Oncology, 2022
BackgroundOwing to its extremely low incidence and the paucity of relevant reports, there is currently no recognized first-line treatment strategy for ovarian large-cell neuroendocrine carcinoma, and there are no statistics related to prognosis derived ...
Li Pang, Zhiqiang Guo
doaj   +1 more source