Results 111 to 120 of about 5,486,230 (294)

Clinical resistance to platinum chemotherapy in ovarian cancer [PDF]

, 2009
Platinum drugs are the most active agents in ovarian cancer. Their cytotoxicty results from DNA crosslinking. High tumour response rates are seen, but 80 % of patients relapse. Major mechanisms of platinum resistance in patients remain to be established.
Newton, C., Newton, C
core  

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

Ovarian Cancer Mortality Predictors in Public Oncology Centers, Addis Ababa, Ethiopia: A Case–Control Study

Cancer Reports
Background Ovarian cancer remains the most lethal gynecologic cancer and has the worst prognosis among all female reproductive malignancies worldwide. In Ethiopia, ovarian cancer is the third most prevalent malignancy among women, following breast and ...
Abrham Tesfaye Habteyes, Jembere Tesfaye Deressa, Roza Teshome Kassa   +2 more
doaj   +1 more source

Rucaparib and Niraparib in Advanced Ovarian Cancer

Journal of the Advanced Practitioner in Oncology, 2019
Rucaparib and niraparib are two of the newest U.S. Food and Drug Administration-approved PARP inhibitors, joining olaparib with indications in ovarian cancer. Both drugs have led to meaningful responses when used as monotherapy in previously treated ovarian cancers, with niraparib demonstrating activity in both BRCA-mutated and BRCA wild-type tumors ...
openaire   +3 more sources

Ovarian cancer serum biomarker discovery using proteomics [PDF]

, 2008
Ovarian cancer is a lethal gynaecological malignancy which is known as the silent killer. It has a poor prognosis due to the lack of major symptoms in early stage disease and hence its late detection.
Kabir, M.
core  

Talazoparib in patients with BRCA mutant metastatic breast or ovarian carcinoma: results of early access program

BMC Cancer
Introduction Talazoparib is a strong PARP inhibitor with significant catalytic inhibition as well as the ability to cause PARP entrapment at DNA damage sites. It is one of the recommended treatments for individuals with BRCA-mutant advanced breast cancer,
Mehmet Ali Nahit Sendur, Mutlu Hizal, Burcu Çakar, Oktay Halit Aktepe, Emrah Eraslan, Zafer Arık, İsmail Erturk, Sercan Aksoy, Semra Paydaş, Serkan Değirmencioğlu, Cihan Erol, Necla Demir, Gülcan Bulut, Naziye Ak, Metin Özkan, Alper Sevinç, Nuriye Özdemir, Umut Dişel, Deniz Tural, Mehmet Artaç, Hacı Mehmet Türk, Serkan Menekşe, Sema Sezgin Göksu, Fatih Köse, Cağlayan Geredeli, Meral Günaldı, Başak Oyan Uluç, Fatma Şen, Kerem Oruç, Ömer Fatih Ölmez, Abdullah Sakin, Umut Demirci, Dilek Erdem, Ferhat Ekinci, Nihat Ökten, Leyla Özer, Kerem Okutur, Atakan Demir, Nuri Karadurmuş, Muhammed Bülent Akıncı, Bülent Yalçın, Erhan Gökmen   +41 more
doaj   +1 more source

SemanticST: A Scalable Multi‐Contextual Graph Learning Framework for Uncovering Spatial Niches and Robust Multi‐Sample Integration in Spatial Transcriptomics

Advanced Science, EarlyView.
Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi, Ahmadreza Argha, Nona Farbehi, Ivan Bakhshayeshi, Thantrira Porntaveetus, Youqiong Ye, Nigel H. Lovell, Hamid Alinejad‐Rokny   +7 more
wiley   +1 more source

IFI27 and BAX are Essential for GSDME‐Mediated Myeloma Cell Pyroptosis

Advanced Science, EarlyView.
The proposed model of GSDME‐mediated MM cell pyroptosis modulated by IFI27 and BAX. IFI27 is downregulated in MM cells. Upon pyroptotic stimulation, such as DOX or ETO treatment, IFI27 is induced, therefore liberating BAX from BCL‐2 ❶. BAX is then recruited to mitochondria and forms homo‐oligomeric channels in OMM, therefore leading to cytochrome C ...
Yaoli Cui, Yuening Sun, Ziyang Liu, Xuntao Lai, Yunshu Zhao, Yan'er Wang, Yuanming He, Fang Xu, Du Feng, Longlong Liu, Zhenqian Huang, Lijie Xing, Xinliang Mao   +12 more
wiley   +1 more source

Advances in nanotechnology-enabled drug delivery for combining PARP inhibitors and immunotherapy in advanced ovarian cancer

Biomolecules & Biomedicine
Advanced ovarian cancer is a malignancy that spreads beyond the ovaries to the pelvis, abdomen, lungs, or lymph nodes. Effective treatment options are available to improve survival rates in patients with advanced ovarian cancer. These include radiation,
Lama Abujamous, Abderrezzaq Soltani, Hamda Al-Thawadi, Abdelali Agouni   +3 more
doaj   +1 more source

Advances in treatment of epithelial ovarian cancer.

Nagoya journal of medical science, 2006
Since most cases of epithelial ovarian cancer are advanced at diagnosis, this disease is one of the most lethal malignancies of the female genital tract. In recent years, aggressive cytoreductive surgery and chemotherapy have been employed in an attempt to improve the survival rate in patients with epithelial ovarian cancer.
Kikkawa, Fumitaka, Nawa, Akihiro, Ino, Kazuhiko, Sibata, Kiyosumi, Kajiyama, Hiroaki, Nomura, Seiji   +5 more
openaire   +2 more sources