Results 211 to 220 of about 5,486,230 (294)

Population Pharmacokinetics and Exposure‐Response Analyses to Support Cofetuzumab Pelidotin (ABBV‐647) Dose Optimization in Non‐Small Cell Lung Cancer Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Cofetuzumab pelidotin (Cofe‐P) is an anti‐protein tyrosine kinase 7 (PTK7) antibody‐drug conjugate (ADC) being investigated for the treatment of adults with PTK7‐expressing, recurrent non‐small cell lung cancer (NSCLC). The first‐in‐human (FIH) trial demonstrated tolerability of dosages ≤ 2.8 mg/kg once every 3 weeks (Q3W) and ≤ 3.2 mg/kg Q2W ...
Carla Biesdorf, Melanie Rinas, Benjamin Engelhardt, Rabih Saab, Cen Guo, Cristiano Ferlini, Kevin J. Freise, Rajeev M. Menon, Akshanth R. Polepally   +8 more
wiley   +1 more source

PARP inhibitor-based first-line maintenance therapy for newly diagnosed advanced ovarian cancer across molecular subgroups: an updated systematic review and network meta-analysis. [PDF]

Front Oncol
Feng J, Qin X, Mo X.
europepmc   +1 more source

Biomarkers of lung congestion and injury in acute heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 781-789, April 2025.
Abstract Acute heart failure (AHF) classification and management are primarily based on lung congestion and/or hypoperfusion. The quantification of the vascular and tissue lung damage is not standard practice though biomarkers of lung injury may play a relevant role in this context.
Marco Guazzi, Gabriele Novello, Francesca Bursi, Anna Caretti, Noemi Furlotti, Ross Arena, Paola Argiento, Julio Núñez, Antoni Bayes‐Genis, Marco Metra   +9 more
wiley   +1 more source

A web-based application to promote palliative care in advanced ovarian cancer: A pre-post design. [PDF]

Gynecol Oncol Rep
Cho S, Pike K, Wolpin S, Wickline M, Tomashek H, Berry DL, Goff BA.   +6 more
europepmc   +1 more source

The Serendipitous Discovery of Rollover Cyclometalation: From Unrecognized Observation to Transformative Chemistry

European Journal of Inorganic Chemistry, EarlyView.
Rollover cyclometalation is a distinctive variant of classical cyclometalation where a chelated heterocyclic ligand undergoes internal rotation, releasing one donor atom from coordination and subsequently activating a remote C─H bond with high regioselectivity.
Antonio Zucca, Maria I. Pilo
wiley   +1 more source

Ex vivo drug sensitivity testing predicts treatment outcomes in advanced ovarian cancer. [PDF]

NPJ Precis Oncol
Labrosse KB, Lombardo FC, Bartoszek EM, Sauteur L, Tanner N, Tanna T, Wolf A, Tunkova B, Kasikova L, Fedier A, Lopez MN, Alborelli I, Beisel C, Kurzeder C, Montavon C, Fucíkova J, Heinzelmann-Schwarz V, Jacob F, Coelho R.   +18 more
europepmc   +1 more source

Autonomous Nanomedicine: Closing the Biological Validation Gap

Exploration, EarlyView.
Delivery of nanoparticles to tumors has not improved in over fifteen years, and biological testing remains slow and separate from formulation design. This review proposes adding a Biology step to the design cycle, using organ chips and patient‐derived organoids, and assesses the readiness of each required technology.
Yan Jun Lin, Izabella Komperda
wiley   +1 more source

Prognostic Value of Combined Neutrophil-to-Lymphocyte Ratio and Prognostic Nutritional Index in Advanced Ovarian Cancer Treated With Neoadjuvant Chemotherapy. [PDF]

Cureus
Ishida H, Egashira H, Asano N, Yudate H, Takashima A, Shimada H.   +5 more
europepmc   +1 more source

Nutrition and Metabolic Diseases: A Systematic Review of Functional Foods, Medicinal Plants, Phytochemicals, Bioactive Compounds and Nutrients Effective Against Metabolic Diseases

Food Chemistry International, EarlyView.
The study demonstrates how functional foods, medicinal plants, phytochemicals, bioactive compounds and essential nutrients combat metabolic diseases. It highlights their mechanisms, including antioxidant, anti‐inflammatory, insulin‐sensitising, lipid‐regulating, gut microbiota‐modulating and mitochondrial‐enhancing effects, leading to improved ...
Chinaza Godswill Awuchi, Sana Noreen, Sonia Morya   +2 more
wiley   +1 more source

Study on key markers of NETosis: predictive indicator for postoperative frailty following complete cytoreductive surgery in advanced ovarian cancer. [PDF]

Front Immunol
Lu X, Xu F.
europepmc   +1 more source