Results 51 to 60 of about 227,548 (263)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Investigating the removal rate of endocrine disrupting compound of diethyl phthalate from aqueous solutions using catalytic ozonation process [PDF]

Muhandisī-i Bihdāsht-i Muḥīṭ, 2023
Background: The emergence of new chemical industries has caused the release of a large amount of organic compounds including industrial by-products, insecticides and other chemicals in nature. Endocrine disrupting compounds are a known group of hazardous
, , , ,
doaj  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

A Review of Methods for the Removal of Endocrine-Disrupting Compounds with a Focus on Oestrogens and Pharmaceuticals Found in Wastewater

Applied Sciences
Steroid hormones are micropollutants that contaminate water worldwide and have significant impacts on human health and the environment, even at very low concentrations.
Jolanta Latosińska, Agnieszka Grdulska
doaj   +1 more source

Use of advanced Fenton and Fenton-like oxidation methods to treat wastewater containing Spiramycin antibiotic

سلامت و محیط, 2021
Background and Objective: Antibiotics are hardly decomposable and resistant contaminants in the environment that according to their anti-biological properties, it is necessary to eliminate or reduce the amount of them before entering the environment ...
Hanieh Mirbolooki, Mehrshad Hajibabaei
doaj  

Advanced oxidation scanning probe lithography

Nanotechnology, 2017
Force microscopy enables a variety of approaches to manipulate and/or modify surfaces. Few of those methods have evolved into advanced probe-based lithographies. Oxidation scanning probe lithography (o-SPL) is the only lithography that enables the direct and resist-less nanoscale patterning of a large variety of materials, from metals to semiconductors;
Ryu, Y. K., García García, Ricardo
openaire   +3 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

The Degradation of Furfural from Petroleum Refinery Wastewater Employing a Packed Bubble Column Reactor Using O₃ and a CuO Nanocatalyst

Reactions
Furfural is one of the main pollutant materials in petroleum refinery wastewater. This work used an ozonized bubble column reactor to remove furfural from wastewater. The reactor applied two shapes of packing materials and two dosages of CuO nanocatalyst
Safiaa M. Mohammed, Ali Abdul Rahman Al Ezzi, Hasan Shakir Majdi, Khalid A. Sukkar   +3 more
doaj   +1 more source