Results 141 to 150 of about 7,267,063 (234)

Advanced Therapy Medicinal Products in Vitiligo; Current Status, Future Prospect, and Approved Treatments. [PDF]

Cell J, 2023
Ghashghaei S, Abbaszadeh M, Karimi S, Ataie-Fashtami L, Bajouri A, Vosough M.   +5 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Engineering the future of advanced therapy medicinal products: a bioengineering call to action. [PDF]

Front Bioeng Biotechnol
Nieri G, Spiller A, Federico S, Aiuti A, Piemonti L.   +4 more
europepmc   +1 more source

The Relevance of Advanced Therapy Medicinal Products in the Field of Transplantation and the Need for Academic Research Access: Overcoming Bottlenecks and Claiming a New Time. [PDF]

Transpl Int, 2023
Piemonti L, Scholz H, de Jongh D, Kerr-Conte J, van Apeldoorn A, Shaw JAM, Engelse MA, Bunnik E, Mühlemann M, Pal-Kutas K, Scott WE, Magalon J, Kugelmeier P, Berishvili E.   +13 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

A roadmap for supporting the development of advanced therapy medicinal products in a European framework. [PDF]

Lancet Reg Health Eur
Van Eldere J, Aiuti A, Lluesma SM, Møller BK, Laursen BE, Lebbe C, Piris A, Carmona J, Goldsobel G, Kintscher U, Vandenberghe P, Huys I, Geers B, Benjamin R, Potter V, Bonini C, Ciceri F, Martino G, Debets R, van der Kuy HPHM, Mielke S, Blomberg P, Ellis E, Müller AMS, Worel N, Künkele A.   +25 more
europepmc   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

The polymeric nanovectors landscape for cancer immunotherapies towards advanced therapy medicinal products (ATMPs). [PDF]

Acta Pharm Sin B
Palamà IE, Invidia A, De Stradis C, Leccese G, Baldari C, Cortese B, Guido C, Giglio A, Quintarelli C, De Angelis B, Maiorano G, Locatelli F, Gigli G.   +12 more
europepmc   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Lentiviral vectors for inducible, transactivator-free advanced therapy medicinal products: Application to CAR-T cells. [PDF]

Mol Ther Nucleic Acids, 2023
Tristán-Manzano M, Maldonado-Pérez N, Justicia-Lirio P, Cortijo-Gutierréz M, Tristán-Ramos P, Blanco-Benítez C, Pavlovic K, Aguilar-González A, Muñoz P, Molina-Estevez FJ, Griesche V, Marchal JA, Heras SR, Benabdellah K, Martin F.   +14 more
europepmc   +1 more source