Results 1 to 10 of about 2,117,768 (268)

Cell therapies in the clinic [PDF]

Bioengineering & Translational Medicine, 2021
AbstractCell therapies have emerged as a promising therapeutic modality with the potential to treat and even cure a diverse array of diseases. Cell therapies offer unique clinical and therapeutic advantages over conventional small molecules and the growing number of biologics.
Lily Li‐Wen Wang, Morgan E. Janes, Ninad Kumbhojkar, Neha Kapate, John R. Clegg, Supriya Prakash, Mairead K. Heavey, Zongmin Zhao, Aaron C. Anselmo, Samir Mitragotri   +9 more
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Adults Myelodysplastic Syndromes in Algeria: A Study by the Algerian MDS Group

Asian Pacific Journal of Cancer Biology, 2023
Introduction: Myelodysplastic syndromes (MDS) are a group of haematological disorders, whose diagnosis is based mainly on cytological studies of blood and marrow cells and cytogenetic analysis.
Mohamed Amine Bekadja, Pierre Fenaux, Sabrina Akrouf, Redhouane Ahmed-Nacer, Rose-marie Hamladji, Amina Bouchakour, Souad Taoussi, Mohand Tahar Abad, Mohamed Bradai, Brahim Benzineb, Naima Mesli, M Cheritti, Z Zouaoui, Mohamed Benlazar, Soraya Bougherira, Fatiha Grifi, Hocine Ait-Ali, Malika allouda, Malika Djillali, Khadija Djouadi, Fatima Kherbache, Selma Hamdi, Hakim Hamouda, Imene Boumeida, Meriem Belhani, Nadia Boudjerra, Fatima Zohra Kaci, Soufi Osmani, Nabil Yafour, Soumia Barkat, Fatma Soltani, Razika Nacib, Mahdia Saidi, Laid Touati, Noureddine Lakhdari, Samira Zouani, Hadj Touhami, Djamel Saidi, Lamia Cherif Louazani, Mohamed Ramaoun, Cherifa Akkal, Nemra Mehalhal, Amina Krim, Noureddine Sidimansour, Zohra Ouchenane, Nadia Zidani, Salim Nekkal, Samia Barkat, Y Ouarlent, Mohamed Aberkane, Salah Eddine Belakehal, Aissa Bachiri, Samir Baghdad   +52 more
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Cell and Cell Free Therapies in Osteoarthritis

Biomedicines, 2021
Osteoarthritis (OA) is the most common articular disease in adults and has a current prevalence of 12% in the population over 65 years old. This chronic disease causes damage to articular cartilage and synovial joints, causing pain and leading to a negative impact on patients’ function, decreasing quality of life.
Pau Peláez, Elena Damiá, Marta Torres-Torrillas, Deborah Chicharro, Belén Cuervo, Laura Miguel, Ayla del Romero, Jose Maria Carrillo, Joaquín J. Sopena, Mónica Rubio   +9 more
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Cell therapy for cystinosis [PDF]

Nephrology Dialysis Transplantation, 2010
In the September 2009 issue of Blood, Syres et al. [1] report on syngeneic bone marrow cell (BMC) and haematopoietic stem cell (HSC) therapy as a successful treatment in a mouse model of cystinosis, an autosomal recessive metabolic disease caused by a defect in the transport of cystine across the lysosomal membrane. The accumulation of cystine crystals
Terryn, Sara, Devuyst, Olivier, Antignac, Corinne   +2 more
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Cell sheets in cell therapies [PDF]

Cytotherapy, 2018
This review aims to provide a broad introduction to the use of cell sheets and the role of materials in the delivery of cell sheets to patients within a clinical setting. Traditionally, cells sheets have been, and currently are, fabricated using established and accepted cell culture methods within standard formats (e.g., petri dishes) utilizing ...
Giles T.S. Kirby, Andrew Michelmore, Louise E. Smith, Jason D. Whittle, Robert D. Short   +4 more
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Characterization of Human-Induced Neural Stem Cells and Derivatives following Transplantation into the Central Nervous System of a Nonhuman Primate and Rats

Stem Cells International, 2022
Neural stem cells (NSCs) and derivatives are potential cellular sources to treat neurological diseases. In the current study, we reprogrammed human peripheral blood mononuclear cells into induced NSCs (iNSCs) and inserted GFP gene into the AAVS1 site for
Mengjia Li, Zhengbo Wang, Tianqi Zheng, Tianzhuang Huang, Baoguo Liu, Deqiang Han, Sumei Liu, Bochao Liu, Mo Li, Wei Si, Y. Alex Zhang, Yuyu Niu, Zhiguo Chen   +12 more
doaj   +1 more source

Enhanced therapeutic effects of mesenchymal stem cell-derived extracellular vesicles within chitosan hydrogel in the treatment of diabetic foot ulcers

Journal of Materials Science: Materials in Medicine, 2023
Extracellular vesicles (EVs) derived from human umbilical cord mesenchymal stem cells (hUCMSCs) have emerged as promising candidates for cell-free therapy in various diseases, including chronic cutaneous wounds.
Shuangshuang Yang, Siyu Chen, Chengpeng Zhang, Jing Han, Chunyuan Lin, Xiaohui Zhao, Huizhen Guo, Yi Tan   +7 more
doaj   +1 more source

Cell Therapy in Dermatology [PDF]

Cold Spring Harbor Perspectives in Medicine, 2014
Harnessing the regenerative capacity of keratinocytes and fibroblasts from human skin has created new opportunities to develop cell-based therapies for patients. Cultured cells and bioengineered skin products are being used to treat patients with inherited and acquired skin disorders associated with defective skin, and further clinical trials of new ...
Petrof, Gabriela, Abdul Wahab, Alya, McGrath, John A.   +2 more
openaire   +3 more sources

Human adipose mesenchymal stem cells modulate myeloid cells toward an anti-inflammatory and reparative phenotype: role of IL-6 and PGE2

Stem Cell Research & Therapy, 2020
Background Mesenchymal stem cells (MSCs) activate the endogenous immune regulatory system, inducing a therapeutic effect in recipients. MSCs have demonstrated the ability to modulate the differentiation of myeloid cells toward a phagocytic and anti ...
Maitane Ortiz-Virumbrales, Ramón Menta, Laura M. Pérez, Ornella Lucchesi, Pablo Mancheño-Corvo, Álvaro Avivar-Valderas, Itziar Palacios, Angel Herrero-Mendez, Wilfried Dalemans, Olga de la Rosa, Eleuterio Lombardo   +10 more
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Comparison of two lab-scale protocols for enhanced mRNA-based CAR-T cell generation and functionality

Scientific Reports, 2023
Process development for transferring lab-scale research workflows to automated manufacturing procedures is critical for chimeric antigen receptor (CAR)-T cell therapies.
Nadine von Auw, Robert Serfling, Reni Kitte, Nadja Hilger, Chengkang Zhang, Clara Gebhardt, Anna Duenkel, Paul Franz, Ulrike Koehl, Stephan Fricke, U. Sandy Tretbar   +10 more
doaj   +1 more source