Results 101 to 110 of about 119,382,614 (307)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Refugee and migrant health system review: challenges and opportunities for long-term health system strengthening in Czechia

x, 43 p.This report presents the findings of a joint review conducted by the World Health Organization and the Ministry of Health of Czechia to assess the health system response to the large-scale arrival of refugees from Ukraine following the Russian ...
World Health Organization
core  

Health care systems in transition: Kyrgyzstan

, 2000
77 p.The Health Systems in Transition (HiT) series provide detailed descriptions of health systems in the countries of the WHO European Region as well as some additional OECD countries.
European Observatory on Health Systems and Policies, World Health Organization. Regional Office for Europe   +1 more
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Health care systems in transition: Hungary

, 1999
100 p.The Health Systems in Transition (HiT) series provide detailed descriptions of health systems in the countries of the WHO European Region as well as some additional OECD countries.
European Observatory on Health Systems and Policies, World Health Organization. Regional Office for Europe   +1 more
core  

The Multiple Advantages of Self-Leadership in Higher Education: The Role of Health-Promoting Self-Leadership among Executive MBA Students

Administrative Sciences
The purpose of this conceptual and explorative study is to document the advantages of health-promoting self-leadership practice. Professional certification programs are criticized due to a lack of practice among participants, involvement, and short ...
Rune Bjerke
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Health care systems in transition: Tajikistan

, 2000
69 p.The Health Systems in Transition (HiT) series provide detailed descriptions of health systems in the countries of the WHO European Region as well as some additional OECD countries.
European Observatory on Health Systems and Policies, World Health Organization. Regional Office for Europe   +1 more
core  

Advantages of statin usage in preventing fractures for men over 50 in the United States: National Health and Nutrition Examination Survey.

PLoS ONE
ObjectivesThe relationship between statin treatment and fracture risk is still controversial, especially in in patients with cardiovascular diseases (CVDs).
Xiaona Sun, Xiaoxiao Liu, Chenyi Wang, Yushuang Luo, Xinyi Li, Lijuan Yan, Yaling Wang, Kaifa Wang, Qiang Li   +8 more
doaj   +1 more source

A review on mushrooms as a versatile therapeutic agent with emphasis on its bioactive constituents for anticancer and antioxidant potential

Exploration of Medicine
Mushrooms, due to their many medical, preventive, and nutraceutical purposes, as well as their reputation as a folk remedy, have long been an integral part of traditional cuisines.
Mohd Javed Naim
doaj   +1 more source