Results 131 to 140 of about 603,619 (344)

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source

The Prevalence of Drug-Drug Interaction and Inappropriate Drug Prescription Among the Elderly in Kashan

Journal of Client-centered Nursing Care, 2019
Background: Drug-Drug Interaction (DDI) among the elderly is one of the major healthcare challenges worldwide. The present study assessed the rates of DDI and inappropriate drug prescription among the elderly in Kashan City, Iran.
Mansour Dianati, Neda Mirbagher Ajorpaz, Mohammad Sajjad Lotfi, Maryam Najarzadeh   +3 more
doaj  

Anti-Tumor Strategies of Photothermal Therapy Combined with Other Therapies Using Nanoplatforms

Pharmaceutics
Conventional cancer treatments often have complications and serious side effects, with limited improvements in 5-year survival and quality of life. Photothermal therapy (PTT) employs materials that convert light to heat when exposed to near-infrared ...
Rubing Xu, Shengmei Wang, Qiuyan Guo, Ruqian Zhong, Xi Chen, Xinhua Xia   +5 more
doaj   +1 more source

Adverse Drug Reactions to Antiretroviral Therapy: Prospective Study in Children in Sikasso (Mali) [PDF]

, 2012
Aboubacar Alassane Oumar, Korotoumou Wélé Diallo, Jean Paul Dembélé, Lassana Samaké, Issa Sidibé, B Togo, Mariam Sylla, Anatole Tounkara, Sounkalo Dao, Paul M. Tulkens   +9 more
openalex   +1 more source

DENTA: A Dual Enzymatic Nanoagent for Self‐Activating Tooth Whitening and Biofilm Disruption

Advanced Functional Materials, EarlyView.
The nanoapatite with dual enzymes (DENTA) accumulates in dentinal tubules, reducing hypersensitivity caused by dental nerve exposure and facilitating continuous ROS generation through salivary glucose for effective, long‐term whitening. The dentin structures remain non‐destructive due to the low concentration of ROS, demonstrating excellent cell ...
Junseok Kim, Dai‐Hwan Kim, Priyannth R. Sundharbaabu, Chae Yeon Lee, Jina Bae, Jiyu Hyun, Young‐Ju Jang, Haeni Kim, Min‐Ho Hong, Juewen Liu, Tobias Fey, Suk Ho Bhang, Jun Hyuk Heo, Jung Heon Lee   +13 more
wiley   +1 more source

Clinical manifestations and risk factors of immune-related thyroid adverse events in patients treated with PD-1 inhibitors: a case-control study

Frontiers in Immunology
BackgroundImmune checkpoint inhibitors (ICPIs) have emerged as a powerful strategy to cancer treatment. However, while demonstrating antitumor efficacy, they can also induce a range of immune-related adverse events (irAEs).
Pengfei Zhao, Jia Li, Lihong Yu, Wenming Ma, Ting Zhao   +4 more
doaj   +1 more source

The value of time‐to‐onset in statistical signal detection of adverse drug reactions: a comparison with disproportionality analysis in spontaneous reports from the Netherlands [PDF]

, 2016
Joep Scholl, Eugène van Puijenbroek
openalex   +1 more source

Host‐Directed Biomaterials for Combatting Bloodstream Infections: From Macrocyclic Peptides to Immune‐Activating Cell Backpacks

Advanced Functional Materials, EarlyView.
Bloodstream infections (BSI) are one of the leading causes of mortality and morbidity in both civilian and military populations. This paper summarizes recent progress in novel treatment strategies to manage BSI arising from both bacterial and fungal pathogens using molecules, particles, and materials to elicit host‐directed immunity.
Thomas Thomou, Jagadish Krishnappa, Justin B. Schaal, Prasad Tongaonkar, Dat Q. Tran, Wenchao Gu, Yung‐Fu Chang, Michael E. Selsted, Shaoyi Jiang, Samir Mitragotri, Michael Super, Christopher J. Bettinger   +11 more
wiley   +1 more source

Implementation of Drug‐Induced Rhabdomyolysis and Acute Kidney Injury in Microphysiological System

Advanced Functional Materials, EarlyView.
A modular Muscle–Kidney proximal tubule‐on‐a‐chip integrates 3D skeletal muscle and renal proximal tubule tissues to model drug‐induced rhabdomyolysis and acute kidney injury. The coculture system enables dynamic tissue interaction, functional contraction monitoring, and quantification of nephrotoxicity, revealing drug side effect‐induced metabolic ...
Jaesang Kim, Zhuo Feng Lee, Gi‐Dong Sim, Sejoong Kim, Jessie S. Jeon   +4 more
wiley   +1 more source

Safety and risk control study of antibody preparation based on CiteSpace

Journal of Holistic Integrative Pharmacy
Objective: To analyze the hotspots, patterns, and distribution of research on the safety and risk of antibody preparations in the past 20 years. It also seeks to summarize the current status and trends of research on the safety and risk control of ...
Chanyuan Chen, Rong Wang, Yuanxuan Cai, Yuhang Zhao, Zherui Chen, Ke Li, Li Zhao, Rui Huang, Nooruldeen Riyadh Ibrahim, Xiaofang Shangguan   +9 more
doaj   +1 more source