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Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Hepatobiliary adverse drug reactions during treatment with olaparib: an analysis of data from the EudraVigilance reporting system. [PDF]

Front Drug Saf Regul
Velişcu EM, Cagnotta C, Sullo MG, Anatriello A, Salvo F, Scavone C.   +5 more
europepmc   +1 more source

Active monitoring vs. spontaneous reporting of antineoplastic drug-related adverse drug reactions: evidence from the Chinese hospital pharmacovigilance system. [PDF]

Front Health Serv
Jing H, Jie D, Zhong W, Xiao M, Qingxuan Z, Sha L, Shuai Z, Yunyan X, Mingxiao L, Yahui L.   +9 more
europepmc   +1 more source

Associations between chronic disease profiles and self-reported adverse drug reactions in community-dwelling older adults: A cross-sectional study. [PDF]

J Korean Gerontol Nurs
Choi HG.
europepmc   +1 more source

A Study of Adverse Drug Reactions to Antiepileptic Drugs in Pediatric Epileptic Patients From North India. [PDF]

Cureus
Kaur P, Kaur A, Kaur M, Singh H, Singh J.   +4 more
europepmc   +1 more source

Development and validation of a predictive nomogram for severe adverse drug reactions: a dual-center pharmacovigilance study. [PDF]

Front Pharmacol
Bu W, Wu X, Wang C, Cai Y.
europepmc   +1 more source

Age and Gender Heterogeneity in Adverse Drug Reactions Associated with Hemp Use: Evidence from the FDA Pharmacovigilance Data in the Last Two Decades. [PDF]

Drugs Real World Outcomes
Teng C, Wu J, Yuan J, Lu ZK.
europepmc   +1 more source

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Adverse drug reactions

The Lancet, 2001
G M, Shenfield, J, Jacka
exaly   +6 more sources

Adverse drug reactions

Medicina Clínica (English Edition), 2020
An adverse drug reaction (ADR) is defined as a response to a medicinal product which is noxious and unintended. ADRs are an important cause of morbidity and mortality and increase health costs. The pharmacovigilance systems allow the identification and prevention of the risks associated with use of a drug, especially of recently marketed drugs; they ...
Eva Montané, Javier Santesmases
openaire   +2 more sources