Results 91 to 100 of about 17,163,674 (412)

Acute Oral Toxicity of Tetrodotoxin in Mice: Determination of Lethal Dose 50 (LD50) and No Observed Adverse Effect Level (NOAEL)

Toxins, 2017
Tetrodotoxin (TTX) is starting to appear in molluscs from the European waters and is a hazard to seafood consumers. This toxin blocks sodium channels resulting in neuromuscular paralysis and even death. As a part of the risk assessment process leading to
P. Abal, M. C. Louzao, A. Antelo, M. Alvarez, E. Cagide, N. Vilariño, M. Vieytes, L. Botana   +7 more
semanticscholar   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Paroxysmal Atrial Fibrillation Induced by Ciprofloxacin: A Rare Adverse Effect

Journal of Pharmaceutical Care, 2020
Despite their adverse effects, fluoroquinolones continue to be commonly prescribed antibiotics. Ciprofloxacin remains the safest with remarkably few adverse effects of all fluoroquinolones.
Fatma Hammami, Makram Koubaa, Sahar Ben Kahla, Amal Chakroun, Khaoula Rekik, Fatma Smaoui, Mounir Ben Jemaa   +6 more
doaj  

Diverse Effects on M1 Signaling and Adverse Effect Liability within a Series of M1 Ago-PAMs.

ACS Chemical Neuroscience, 2017
Both historical clinical and recent preclinical data suggest that the M1 muscarinic acetylcholine receptor is an exciting target for the treatment of Alzheimer's disease and the cognitive and negative symptom clusters in schizophrenia; however, early ...
J. M. Rook, Masahito Abe, Hyekyung P. Cho, Kellie D. Nance, Vincent B Luscombe, Jeffrey Adams, J. Dickerson, Daniel H. Remke, Pedro M Garcia-Barrantes, D. Engers, Julie L Engers, Sichen Chang, Jarrett J Foster, Anna L Blobaum, C. Niswender, Carrie K Jones, P. J. Conn, C. Lindsley   +17 more
semanticscholar   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

Molecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop, Edgar Cardenas De La Hoz, Hanne Verswyvel, Joey De Backer, Ho Wa Lau, Angela Privat‐Maldonado, Wim Vanden Berghe, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts, Abraham Lin   +10 more
wiley   +1 more source

Strategies to reduce the cancer burden and improve access to effective and affordable cancer interventions in Europe

Molecular Oncology, EarlyView.
Comprehensive cancer centre (CCCs) and CCCs of Excellence (CCCoE) integration in healthcare. Through outreach to surrounding community hospitals, CCCs enable wider access to top‐clinical cancer treatments and care, thereby facilitating the swift enrolment of patients into data‐rich clinical trials (PI‐initiated trials testing new concepts, drug ...
Anton Berns, Ulrik Ringborg, Julio Celis, Bengt Jönsson, Michael Baumann   +4 more
wiley   +1 more source

Frequency and Perception of Sexual Activity during Pregnancy in Iranian Couples [PDF]

International Journal of Fertility and Sterility, 2012
Background Pregnancy stimulates partners to search for ways to preserve their mutual emotional relations and satisfy their sexual needs, with some limitations.
Farahnaz Torkestani, Shahrzad Hadavand Hadavand, Zohreh Khodashenase, Sima Besharat, Ali Davati, Zohreh Karimi, Nafiseh Zafarghandi   +6 more
doaj  

Unions, Innovation, and Technology Adoption: New insights from the cross-country evidence [PDF]

There is currently no consensus regarding the effect of unions on technology. We apply meta-regression analysis to the extant econometric studies and find that unions depress investment in new technology.
Hristos Doucouliagos, Patrice Laroche
core  

Refugee status and religious conversion: The significance of refugee appeal number 76204 [PDF]

, 2010
Doug Tennent from Waikato University considers the effect of adverse findings of credibility in a refugee claim involving religious conversion and cautions the need for support agencies to act with care when assisting people with refugee ...
Tennent, Douglas
core   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source