Results 61 to 70 of about 11,663,292 (306)

Dasatinib‐induced hypoglycemia in a patient with acute lymphoblastic leukemia

Clinical Case Reports, 2020
Tyrosine kinase inhibitors can cause significant hypoglycemia in patients with diabetes on other antihyperglycemic medications. These patients should be monitored, and their medications adjusted accordingly.
Michelle D. Lundholm, Gerald A. Charnogursky   +1 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Design of a retrospective patient record study on the occurrence of adverse events among patients in Dutch hospitals [PDF]

, 2009
Background: Various international studies have shown that a substantial number of patients suffer from injuries or even die as a result of care delivered in hospitals.
van der Wal Gerrit, Bruijne, M.C. de, Maurits W van Tulder, Asscheman Henk, van Tulder Maurits W, Waaijman, Roelof, Waaijman, R., de Bruijne, M.C., Asscheman, Henk, van der Wal, Gerrit, Zegers Marieke, Hoonhout, L.H.F., Peter Spreeuwenberg, Spreeuwenberg, Peter, Tulder, M.W. van, van der Wal, G., Wal, Gerrit van der, de Bruijne, Martine C., Marieke Zegers, Hoonhout Lilian HF, Lilian HF Hoonhout, Cordula Wagner, Wal, G. van der, Wagner, C., van Tulder, M.W., Wagner, Cordula, Zegers, H.W.M., Gerrit van der Wal, Martine C de Bruijne, Henk Asscheman, Groenewegen, Peter P., Spreeuwenberg Peter, de Bruijne Martine C, Zegers, M., Roelof Waaijman, Wagner Cordula, Spreeuwenberg, P., van Tulder, Maurits W., Hoonhout, Lilian H. F., Waaijman Roelof, Zegers, Marieke, Asscheman, H., Bruijne, Martine C. de, van Tulder, M.W.; id_orcid   +43 more
core   +4 more sources

Clinical Efficacy and Adverse Effects of Antibiotics Used to Treat Mycobacterium abscessus Pulmonary Disease

Frontiers in Microbiology, 2019
Treatment of Mycobacterium abscessus pulmonary infection requires long-term administration of multiple antibiotics. Little is known, however, about the impact of each antibiotic on treatment outcomes.
Jianhui Chen, Jianhui Chen, Lan Zhao, Yanhua Mao, Meiping Ye, Qi Guo, Qi Guo, Yongjie Zhang, Yongjie Zhang, Liyun Xu, Zhemin Zhang, Bing Li, Haiqing Chu, Haiqing Chu   +13 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

A structural equation model of adverse events and length of stay in hospitals [PDF]

Adverse events in hospitals cause significant morbidity and mortality, and considerable effort has been invested into analysing their incidence and preventability. An unresolved issue in models of medical adverse events is potential endogeneity of length
Katharina Hauck, Xueyan Zhao
core  

Trends in hospital admissions for adverse drug reactions in England: analysis of national hospital episode statistics 1998-2005. [PDF]

, 2007
BACKGROUND: Adverse drug reactions (ADRs) are a frequent cause of mortality and morbidity to patients worldwide, with great associated costs to the healthcare providers including the NHS in England.
Majeed, Azeem, Patel, M, Car, J, Molokhia, Mariam, Mariam Molokhia, Janakan Srishanmuganathan, Patel, H, Bell, Derek, Car, Josip; id_orcid, Srishanmuganathan, Janakan, Car, Josip, Majeed, A, Mitesh Patel, Patel, Hitesh, Josip Car, Bell, D, Molokhia, M, Patel, Mitesh, Derek Bell, Srishanmuganathan, J, Hitesh Patel, Azeem Majeed   +21 more
core   +2 more sources

Galectin-3 as a Therapeutic Target for NSAID-Induced Intestinal Ulcers

Frontiers in Immunology, 2020
Non-steroidal anti-inflammatory drugs (NSAIDs) induce ulcers in the gastrointestinal tract, including the stomach and small intestine. NSAID-induced gastric ulcers can be prevented by taking acid-neutralizing/inhibitory drugs and cytoprotective agents ...
Ah-Mee Park, Sundar Khadka, Fumitaka Sato, Seiichi Omura, Mitsugu Fujita, Daniel K. Hsu, Fu-Tong Liu, Fu-Tong Liu, Ikuo Tsunoda   +8 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source