Results 151 to 160 of about 6,670,507 (363)

Implementing a 48 h EWTD-compliant rota for junior doctors in the UK does not compromise patients’ safety : assessor-blind pilot comparison [PDF]

, 2009
Background: There are currently no field data about the effect of implementing European Working Time Directive (EWTD)-compliant rotas in a medical setting.
Bennett-Jones, David, Lowe, Alice, Taggart, Frances M., Sullivan, J.P., Landrigan, C. P., Pounder, R., Cappuccio, Francesco, Kamdala, N B, Lockley, S. W., Taggart, Frances, Cooper, Dan, Landrigan, Christopher, Czeisler, Charles, Miller, Marianne, Edmunds, Mair, Bakewell, A., Lockley, Steven, Ward, Gregory, Chen, Ji, Pohl, Joseph, Kidd, Jane, Peile, Ed, Sullivan, Jason, Ward, G., Edmunds, M., Bakewell, Anne, Pounder, Roy, Ji, Chen, Short, Alasdair   +28 more
core   +1 more source

Comparison of immune checkpoint inhibitors related to pulmonary adverse events: a retrospective analysis of clinical studies and network meta-analysis

BMC Medicine
Background Immune checkpoint inhibitors (ICIs) have transformed tumor treatment. However, the risk of pulmonary adverse events (PAEs) associated with ICI combination therapy is still unclear.
Baohui Hong, Bin Du, Rong Chen, Caiyun Zheng, Ruping Ni, Maobai Liu, Jing Yang   +6 more
doaj   +1 more source

Target-specific cardiotoxicity of tyrosine kinase inhibitors: a Systematic Review and meta-analysis

Frontiers in Pharmacology
ObjectiveTo assess the association between different tyrosine kinase inhibitors (TKIs) and the risk of major adverse cardiovascular events (MACE).Data sourcesPubMed, the Cochrane Library, Embase, WanFang Data, and CNKI were searched for randomized ...
Zhe Wang, Zhe Wang, Zhiling Cheng, Zhiling Cheng, Yifan Zheng, Yifan Zheng, Yang Liu, Zhihan Zhang, Yuan Gao, Congxin Li, Congxin Li   +10 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Adverse events as a measure of patient safety in cancer care [PDF]

, 2020
“First, do no harm” is a fundamental element of health care and considered indistinguishable from the delivery of quality in health care. While cancer care has become more effective, it has also become more complex consequently increasing the risk for ...
Haukland, Ellinor Christin
core  

Fibrinogen is Associated with Clinical Adverse Events in Patients with Psoriasis and Coronary Artery Disease [PDF]

, 2023
Lin Zhao,* Yan Zeng,* Lin Sun, ZengLei Zhang, KunQi Yang, ZuoZhi Li, Man Wang, XianLiang Zhou, WeiXian Yang Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union
Sun L, Wang M, Yang W, Zhao L, Li Z, Zhang Z, Yang K, Zeng Y, Zhou X   +8 more
core  

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Honesty about adverse events - more honoured in the breach than in the observance [PDF]

, 2011
The medical board of Australia Code of conduct reminds doctors that" "When adverse events occur, you have a responsibility to be open and honest in your communication with your patient, to review what has occurred and to report appropriately."\ud \ud ...
Cockburn, Tina, Madden, Bill
core  

Evaluation of Adverse Events during Plateletpheresis – A Retrospective Study

Indian Journal of Medical Specialities
Introduction: Apheresis is a routine procedure which is well tolerated but may be associated with different adverse events (AEs). In this study, the frequency of various AEs associated with apheresis was evaluated, and the donor variables were analyzed ...
Shivali Sehgal, Priti Chatterjee, Swati Bhardwaj, Reema Bhushan, Chintamani Pathak, Manjula Jain   +5 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source