Results 11 to 20 of about 5,575,329 (338)

Immune-related adverse events and the balancing act of immunotherapy

Nature Communications, 2022
The benefit from immune checkpoint inhibitors is tempered by immunologic toxicities, which involve diverse organs, have varying biology, onset time, and severity. Herein, we identify important areas of controversy and open research questions in the field
M. Conroy, J. Naidoo
semanticscholar   +1 more source

Bio-based poly(ethylene furanoate)/ZnO transparent thin films with improved water vapor barrier and antibacterial properties for food packaging application

Materials Research Express, 2022
Poly(ethylene furanoate) (PEF) biocomposite films incorporating zinc oxide nanoparticle (ZnO NPs) were prepared using a solvent casting method. The ZnO NPs were homogeneously dispersed within the PEF films with the aid of γ −aminopropyltriethoxylsilane ...
Chaoting Zhu, Jianbing Yin, Zhilong Zhang, Feng Shi   +3 more
doaj   +1 more source

Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immune checkpoint inhibitor-related adverse events

Journal for ImmunoTherapy of Cancer, 2021
Immune checkpoint inhibitors (ICIs) are the standard of care for the treatment of several cancers. While these immunotherapies have improved patient outcomes in many clinical settings, they bring accompanying risks of toxicity, specifically immune ...
J. Brahmer, Hamzah Abu-Sbeih, P. Ascierto, J. Brufsky, L. Cappelli, Frank B. Cortazar, D. Gerber, L. Hamad, Eric D. Hansen, Douglas B. Johnson, M. Lacouture, G. Masters, J. Naidoo, M. Nanni, M. Perales, I. Puzanov, B. Santomasso, S. Shanbhag, Rajeev Sharma, D. Skondra, J. Sosman, M. Turner, M. Ernstoff   +22 more
semanticscholar   +1 more source

IL12/23 Blockade with Ustekinumab as a Treatment for Immune-Related Cutaneous Adverse Events

Pharmaceuticals, 2023
Background: Immune-related cutaneous adverse events (ircAEs) are frequent and may reduce quality of life and consistent dosing. IL12/23 has been implicated in psoriasis, which is reminiscent of the psoriasiform/lichenoid ircAE phenotype.
Stephanie L. Gu, Tara Maier, Andrea P. Moy, Stephen Dusza, David M. Faleck, Neil J. Shah, Mario E. Lacouture   +6 more
doaj   +1 more source

Gastrointestinal adverse events associated with semaglutide: A pharmacovigilance study based on FDA adverse event reporting system

Frontiers in Public Health, 2022
Background Semaglutide was approved for treatment of type 2 diabetes mellitus (T2DM) and chronic weight management in obesity or overweight adults. However, real-world data regarding its long-term gastrointestinal safety and tolerability in large sample ...
Yamin Shu, Xucheng He, Pan Wu, Yanxin Liu, Yufeng Ding, Qilin Zhang   +5 more
semanticscholar   +1 more source

Adverse events [PDF]

American Journal of Orthodontics and Dentofacial Orthopedics, 2017
Any medical intervention generates modifications in the homeostasis of the treated organism. The effect in most cases is not apparent at the clinical level; when manifested, it may be inherent to the expected therapeutic action or associate as a side effect expressed in a multiplicity of epiphenomena with different physiognomy and capacity of altering ...
openaire   +4 more sources

Surveillance for Adverse Events After COVID-19 mRNA Vaccination.

Journal of the American Medical Association (JAMA), 2021
Importance Safety surveillance of vaccines against COVID-19 is critical to ensure safety, maintain trust, and inform policy. Objectives To monitor 23 serious outcomes weekly, using comprehensive health records on a diverse population. Design, Setting,
N. Klein, N. Lewis, Kristin Goddard, B. Fireman, O. Zerbo, K. Hanson, J. Donahue, E. Kharbanda, A. Naleway, J. Nelson, Stanley Xu, W. K. Yih, J. Glanz, Joshua T. B. Williams, S. Hambidge, Bruno J Lewin, T. Shimabukuro, F. Destefano, Eric S. Weintraub   +18 more
semanticscholar   +1 more source

Adverse Events in Pediatric Inpatients: The Japan Adverse Event Study

Journal of Patient Safety, 2023
Objectives Adverse events (AEs) represent an important cause of morbidity and mortality for pediatric inpatients; however, reports on their epidemiology in pediatrics, especially outside Western countries, are scarce. We investigated the incidence and nature of AEs in pediatric inpatients in Japan.
Sakuma, Mio, Ohta, Yoshinori, Takeuchi, Jiro, Yuza, Yuki, Ida, Hiroyuki, Bates, David W., Morimoto, Takeshi   +6 more
openaire   +2 more sources

Overlap between adverse events (AEs) and serious adverse events (SAEs): a case study of a phase III cancer clinical trial

Trials, 2020
Background Safety data is required to be collected in all clinical trials and can be separated into two types of data, adverse events and serious adverse events.
Elizabeth C. James, David Dunn, Adrian D. Cook, Andrew R. Clamp, Matthew R. Sydes   +4 more
doaj   +1 more source

Adverse Events in NMOSD Therapy [PDF]

International Journal of Molecular Sciences, 2022
Neuromyelitis optica spectrum disorders (NMOSD) are rare neurologic autoimmune diseases that have a poor prognosis if left untreated. For many years, generic oral immunosuppressants and repurposed monoclonal antibodies that target the interleukin-6 pathway or B cells were the mainstays of drug treatment.
Katrin Giglhuber, Achim Berthele
openaire   +2 more sources