Results 41 to 50 of about 3,069,358 (214)

Safety and Tolerability of Givinostat: Evidence From Real‐World and Clinical Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aim of our study was to establish the prevalence of adverse events in a real‐world setting in boys living with Duchenne muscular dystrophy (DMD) treated with givinostat as part of an Expanded Access Program (EAP) in Italy. Methods The cohort included 90 ambulant boys, with age when treatment started between 6 and 23 years (mean ...
Marika Pane, Anna Capasso, Chiara Arpaia, Adele D’Amico, Emilio Albamonte, Federica Trucco, Maria Sframeli, Riccardo Masson, Francesca Magri, Luca Bello, Romina Venditti, Claudia Dosi, Michela Catteruccia, Michele Tosi, Claudio Bruno, Sonia Messina, Giacomo Comi, Elena Pegoraro, Valeria A. Sansone, Eugenio Mercuri   +19 more
wiley   +1 more source

Adverse maternal and neonatal outcomes among singleton pregnancies in women of very advanced maternal age: a retrospective cohort study

BMC Pregnancy and Childbirth, 2019
Background There is an increasing prevalence of women who tend to delay childbirth until a very advanced age. However, there is sparse data regarding very advanced maternal age (vAMA) and the interplay between vAMA and assisted reproductive technology ...
Yuelin Wu, Yan Chen, Minxue Shen, Yanfang Guo, Shi Wu Wen, Andrea Lanes, Ruth Rennicks White, Adewumi Adanlawo, Mark Walker, Xiaolin Hua   +9 more
doaj   +1 more source

Metabolic effects of a high-fat diet post-weaning after low maternal dietary folate during pregnancy and lactation [PDF]

, 2014
Scope Investigate the influence of low-folate supply during pregnancy and lactation on obesity and markers of the metabolic syndrome in offspring, and how provision of a high-fat diet post weaning may exacerbate the resultant phenotype.
Sabine A. S. Langie, Caroline Manus, Jill A. McKay, Mckay, Jill A., Maxwell, Ross J., Manus, Caroline, Dianne Ford, Maxwell, Ross, Long Xie, Ross J. Maxwell, Langie, Sabine A.S.; id_orcid, Xie, Long, Mathers, John C., McKay, Jill, Langie, Sabine, Ford, Dianne, John C. Mathers   +16 more
core   +1 more source

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

Is there an association between maternal anxiety propensity and pregnancy outcomes?

BMC Pregnancy and Childbirth, 2018
Background Several studies have shown inconsistent associations between anxiety during pregnancy and adverse pregnancy outcome. This inconsistency may be due to lack of controlling for the timing and type of maternal anxiety.
Eyal Ravid, Liat Salzer, Liat Arnon, Michal Eisner, Arnon Wiznitzer, Aron Weller, Lee Koren, Eran Hadar   +7 more
doaj   +1 more source

Association between maternal serum homocysteine concentrations in early pregnancy and adverse pregnancy outcomes

, 2020
Background: There is still conflicting evidence on the extent to which maternal hyperhomocysteinemia is a risk factor for pregnancy complications. Aims: The study aimed to investigate the impact of elevated maternal homocysteine concentrations on adverse
Nwogu, C., Sekumade, A., John-Olabode, S., Okunade, K., Adenekan, M., Oluwole, A.   +5 more
core   +1 more source

Maternal tobacco, cannabis and alcohol use during pregnancy and risk of adolescent psychotic symptoms in offspring [PDF]

, 2009
Background Adverse effects of maternal substance use during pregnancy on fetal development may increase risk of psychopathology. Aims To examine whether maternal use of tobacco, cannabis or alcohol during pregnancy increases risk of offspring ...
David Gunnell, Dieter Wolke, Jeremy Horwood, Kate Thomas, Andrew Thompson, Gunnell, David, Lewis, Glyn, Harrison, Glynn, Stanley Zammit, Paulo Menezes, Hollis, Chris, Glyn Lewis, Wolke, Dieter, Zammit, Stanley, Horwood, Jeremy, Thomas, Kate, Thompson, Andrew D., Menezes, Paulo, Chris Hollis, Glynn Harrison, Thompson, Andrew   +20 more
core   +1 more source

Assessing the Sensitivity and the Clinical Impact of the 2023 American College of Rheumatology/EULAR Classification Criteria in Obstetric Antiphospholid Syndrome: Findings From a Multicenter Italian Cohort With a Long‐Term Follow‐Up

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to evaluate the sensitivity of the 2023 American College of Rheumatology (ACR)/EULAR classification criteria for antiphospholipid syndrome (APS) in a real‐world cohort of women diagnosed with primary obstetric APS (oAPS) and to assess their ability to identify patients at risk of future pregnancy complications ...
Francesca Ruffilli, Cecilia Nalli, Francesca Crisafulli, Carlo Garaffoni, Marcello Govoni, Giulia Voltarel, Alba C. Pozzi, Beatrice Maranini, Ettore Silvagni, Alessandra Bortoluzzi, Angela Tincani   +10 more
wiley   +1 more source

Does extreme maternal age still act as a risk factor for adverse perinatal outcome? Evidence from Poland 20 years after the social and economic transformation

Anthropological Review, 2019
It was examined whether positive changes in maternal SES and medical facilities in Poland 20 years after social and economic transformation weakened the role of maternal age in shaping perinatal outcome.
Kosińska Magdalena, Hadada Tomasz, Liczbińska Grażyna   +2 more
doaj   +1 more source

PIERS calculator- predicting adverse maternal outcome in preeclampsia [PDF]

, 2017
Background: Preeclampsia is a multisystem, highly variable disorder unique to pregnancy. For preeclampsia arising remote from term, supportive and temporizing measures are used to improve perinatal outcome.
Shubha Srivastava, Neha Jain, Parihar, Bharti Chaudhary, Srivastava, Shubha, Bharti Chaudhary Parihar, Jain, Neha   +5 more
core   +1 more source