Results 61 to 70 of about 3,069,358 (214)

Role of placental, fetal and maternal cardiovascular markers in predicting adverse outcome in women with suspected or confirmed pre‐eclampsia

, 2022
Objective: To assess the performance of placental, fetal and maternal cardiovascular markers in the prediction of adverse perinatal and maternal outcomes in women with suspected or confirmed pre-eclampsia.
M. Reddy, Rolnik, D.L., Reddy, M, Palmer, K, Mol, BW, Da Silva Costa, F, Da Silva Costa, F., Reddy, M., D. L. Rolnik, Wallace, E.M., Palmer, K., K. Palmer, F. Da Silva Costa, Mol, B.W., Wallace, EM, E. M. Wallace, B. W. Mol, Rolnik, DL   +17 more
core   +1 more source

Targeting GALNT7 Disrupts the TAZ O‐GalNAcylation Feedback Loop to Suppress Gallbladder Cancer Progression

Advanced Science, EarlyView.
Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu, Ming Zhang, Yunxiang Feng, Yibo Deng, Kai Zhao, Xiangyu Li, Yun Lu, Li Tian, Tao Yang, Wei Yao, Jianming Wang, Zhengdong Deng   +11 more
wiley   +1 more source

Risks and benefits of psychotropic medication in pregnancy: cohort studies based on UK electronic primary care health records

Health Technology Assessment, 2016
Background: Although many women treated with psychotropic medication become pregnant, no psychotropic medication has been licensed for use in pregnancy. This leaves women and their health-care professionals in a treatment dilemma, as they need to balance
Irene Petersen, Rachel L McCrea, Cormac J Sammon, David PJ Osborn, Stephen J Evans, Phillip J Cowen, Nick Freemantle, Irwin Nazareth   +7 more
doaj   +1 more source

Perinatal outcomes in twin pregnancies complicated by maternal morbidity: evidence from the WHO Multicountry Survey on Maternal and Newborn Health

BMC Pregnancy and Childbirth, 2018
Background Twin pregnancy was associated with significantly higher rates of adverse neonatal and perinatal outcomes, especially for the second twin. In addition, the maternal complications (potentially life-threatening conditions-PLTC, maternal near miss-
Danielly S. Santana, Carla Silveira, Maria L. Costa, Renato T. Souza, Fernanda G. Surita, João P. Souza, Syeda Batool Mazhar, Kapila Jayaratne, Zahida Qureshi, Maria H. Sousa, Joshua P. Vogel, José G. Cecatti, on behalf of the WHO Multi-Country Survey on Maternal and Newborn Health Research Network   +12 more
doaj   +1 more source

Maternal near-miss and mortality associated with hypertensive disorders of pregnancy remote from term: a multicenter observational study in Ghana [PDF]

, 2022
BACKGROUND: Maternal death rates remain high in many low- and middle-income countries. Hypertensive disorders of pregnancy account for 18% of maternal mortality in Ghana.
Severe Preeclampsia adverse Outcome Triage (SPOT) studies consortium
core  

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

Improving reporting of adverse drug reactions: Systematic review. [PDF]

, 2009
BACKGROUND: Adverse drug reactions (ADRs) are a significant cause of morbidity and mortality, with many being identified post-marketing. Improvement in current ADR reporting, including utility of underused or innovative methods, is crucial to improve ...
Molokhia, Mariam, Mariam Molokhia, Tanna, S, Molokhia, M, Bell, D, Bell, Derek, Derek Bell, Tanna, Shivani, Shivani Tanna   +8 more
core   +1 more source

Long Noncoding RNA PCALRx Interacts with Pyruvate Carboxylase to Drive Multi‐Organ Developmental Toxicity in Zebrafish Embryos Exposed to Amoxicillin

Advanced Science, EarlyView.
Embryonic amoxicillin exposure disrupts multi‐organ development in zebrafish larvae through a lncRNA–metabolic enzyme regulatory axis. PCALRx associates with pyruvate carboxylase, promotes PC protein ubiquitination, and impairs mitochondrial energy metabolism, while vitamin B1 partially restores PC‐centered metabolic function and developmental outcomes.
Yixue Yao, Ping Jiang, Xinli Zhou, Mengying Yin, Qiong Luo, Hui Wang   +5 more
wiley   +1 more source

Maternal education and its association with maternal and neonatal adverse outcomes in live births conceived using medically assisted reproduction (MAR)

Maternal Health, Neonatology and Perinatology, 2023
Background To examine the association between maternal education and adverse maternal and neonatal outcomes in women who conceived using medically assisted reproduction, which included fertility medications, intrauterine insemination, or in vitro ...
Cassie L. Hobbs, Christina Raker, Gabrielle Jude, Jennifer L. Eaton, Stephen Wagner   +4 more
doaj   +1 more source

Maternal aflatoxin exposure during pregnancy and adverse birth outcomes in Uganda [PDF]

, 2018
Aflatoxins are toxic metabolites of Aspergillus moulds and are widespread in the food supply, particularly in low- and middle-income countries.
Griffiths, Jeffrey K., Webb, Patrick, Nshakira, Nathan, Ausman, Lynne M., Xue, Kathy S., Lauer, Jacqueline M., Agaba, Edgar, Ghosh, Shibani, Duggan, Christopher P., Wang, Jia-Sheng   +9 more
core   +1 more source