Results 61 to 70 of about 3,485,469 (299)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Doctor of Pharmacy [PDF]

, 1984
dissertationIn July 1979, in accordance with the Joint Commission on Accreditation of Hospitals (JCAH) standards, the Pharmacy and Therapeutics Committee approved a policy for reporting adverse drug reactions (ADRs) occurring within the 370-bed ...
Nightingale, James Barrett
core  

Evaluation of patient reporting of adverse drug reactions to the UK ‘Yellow Card Scheme’: literature review, descriptive and qualitative analyses, and questionnaire surveys [PDF]

, 2011
Background: The monitoring of adverse drug reactions (ADRs) through pharmacovigilance is vital to patient safety. Spontaneous reporting of ADRs is one method of pharmacovigilance, and in the UK this is undertaken through the Yellow Card Scheme (YCS ...
DJ McLernon, Murphy, E., Fortnum, H, Watson, M C, McLernon, D.J., Hazell, L, Gifford, A., MC Watson, Fortnum, H., Watson, M.C., Bond, C. M., Lee, A.J., Avery, A J, Bond, Christine, Hannaford, P.C., Krska, Janet, Watson, M. C., Avery, Anthony, J Krska, Krska, J, Mclernon, David J., Hannaford, P C, Shakir, S., Lee, A J, Lee, A. J., Gifford, A, Murphy, E, CM Bond, E Murphy, L Hazell, Hazell, L., Gifford, Alison, Watson, Margaret C., A Gifford, H Fortnum, AJ Avery, Bond, C.M., C Anderson, Anderson, C., Anderson, C, S Shakir, McLernon, D. J., McLernon, D J, Anderson, Claire, Bond, C M, Fortnum, Heather, Shakir, S, Avery, A. J., PC Hannaford, Murphy, Elizabeth, Hannaford, P. C., Hannaford, Philip C., AJ Lee, Krska, J.   +53 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Montelukast Prevents Mice Against Acetaminophen-Induced Liver Injury

Frontiers in Pharmacology, 2019
Acetaminophen (APAP) is a widely used over-the-counter antipyretic and analgesic drug. Overdose of APAP is the leading cause of hospital admission for acute liver failure.
Shiyun Pu, Qinhui Liu, Yanping Li, Rui Li, Tong Wu, Zijing Zhang, Cuiyuan Huang, Xuping Yang, Jinhan He, Jinhan He   +9 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Atox1 regulates macrophage polarization in intestinal inflammation via ROS-NLRP3 inflammasome pathway

Journal of Translational Medicine
Background Inflammation and oxidative stress play an important role in the pathophysiology of inflammatory bowel disease (IBD). This study aimed to explore the effects of copper chaperone Antioxidant-1 (Atox1) on macrophages in a mouse model of ...
MingXian Chen, Yu Chen, Rui Fu, SaiYue Liu, HaiXia Li, TangBiao Shen   +5 more
doaj   +1 more source

Adverse reaction to disopyramide [PDF]

Postgraduate Medical Journal, 1979
SummaryA case is reported where the use of i.v. disopyramide for a supraventricular tachycardia resulted in a more serious ventricular dysrhythmia giving hypotension and this probably contributed to the development of a myocardial infarction. Attention is drawn to the possible risk.
J B, Dibble, N R, Webster
openaire   +2 more sources

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Cimetidine-Associated Adverse Reaction

, 1990
Cimetidine, a histamine2-receptor antagonist, is used in the treatment and prophylaxis of peptic ulcer disease. Its use is relatively free of serious adverse reactions and only a few accounts of hypersensitivity exist.
Wilfred Lam, Alan H. Mutnick, Edward J. Drea, Dominic P. Palazzolo   +3 more
core   +1 more source