Results 1 to 10 of about 1,102,054 (309)
Pilot study: Evaluation of potential drug–drug interactions in hospitalized pediatric patients
Pediatrics and Neonatology, 2020 Purpose: Evaluate the type and severity of potential drug-drug interactions and identify risk factors involved, in pediatric patients admitted in a hospital setting.
Fabiola Medina-Barajas +6 more
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Therapeutic Advances in Chronic Disease, 2022 Background: Multiple sclerosis (MS) is the most common immune-mediated demyelinating disease in younger adults. Patients with MS (PwMS) are vulnerable to the presence of potential drug–drug interactions (pDDIs) and potential drug–food interactions (pDFIs)
Jane Louisa Debus +9 more
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Pharmacodynamic Drug–Drug Interactions [PDF]
Clinical Pharmacology & Therapeutics, 2019 Pharmacodynamic drug–drug interactions (DDIs) occur when the pharmacological effect of one drug is altered by that of another drug in a combination regimen. DDIs often are classified as synergistic, additive, or antagonistic in nature, albeit these terms are frequently misused.
Jin, Niu +2 more
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Neutralization of cholera toxin by Rosaceae family plant extracts
BMC Complementary and Alternative Medicine, 2019 Background Cholera is one of the most deadly diarrheal diseases that require new treatments. We investigated the neutralization of cholera toxin by five plant extracts obtained from the Rosaceae family that have been traditionally used in Poland to treat
Magdalena Komiazyk +4 more
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How Informative Are Drug‐Drug Interactions of Gene‐Drug Interactions?
The Journal of Clinical Pharmacology, 2016 AbstractFDA recommendations to manage polymorphic CYP‐mediated drug‐drug interactions (DDIs) and gene‐drug interactions (GDIs) are typically similar. However, DDIs may not always reliably predict GDIs because the victim drug may have multiple metabolic pathways and the perpetrator drug may affect multiple enzymes or transporters. Consequently, it is of
Chakradhar V, Lagishetty +5 more
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Drug-Drug Interaction of Antifungal Drugs
YAKUGAKU ZASSHI, 2005 This article reviews the in vitro metabolic and the in vivo pharmacokinetic drug-drug interactions with antifungal drugs, including fluconazole, itraconazole, micafungin, miconazole, and voriconazole. In the in vitro interaction studies, the effects of antifungal drugs on specific activities of cytochrome P450s (CYPs), including CYP1A2, CYP2C9, CYP2C19,
Toshiro, Niwa +2 more
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Clinical Interventions in Aging, 2022 Limi Adem, Gobezie T Tegegne Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Science, Addis Ababa University, Addis Ababa, EthiopiaCorrespondence: Gobezie T Tegegne, Email gobezie.temesgen@aau.edu.etBackground ...
Adem L, Tegegne GT
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Quantitative Biology, 2023 Computational methods for DDIs and DTIs prediction are essential for accelerating the drug discovery process. We proposed a novel deep learning method DeepDrug, to tackle these two problems within a unified framework.
Qijin Yin +5 more
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Journal of CheminformaticsIn drug development, managing interactions such as drug–drug, drug–disease, and drug–nutrient is critical for ensuring the safety and efficacy of pharmacological treatments.
Nour H. Marzouk +4 more
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Measuring drug similarity using drug–drug interactions
Quantitative BiologyCombination therapy is a promising approach to address the challenge of antimicrobial resistance, and computational models have been proposed for predicting drug–drug interactions.
Ji Lv +4 more
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