Results 1 to 10 of about 7,761,768 (249)

Drug screening and genome editing in human pancreatic cancer organoids identifies drug-gene interactions and candidates for off-label treatment. [PDF]

Cell Genom, 2022
Pancreatic cancer (PDAC) is a highly aggressive malignancy for which the identification of novel therapies is urgently needed. Here, we establish a human PDAC organoid biobank from 31 genetically distinct lines, covering a representative range of tumor ...
Hirt CK, Booij TH, Grob L, Simmler P, Toussaint NC, Keller D, Taube D, Ludwig V, Goryachkin A, Pauli C, Lenggenhager D, Stekhoven DJ, Stirnimann CU, Endhardt K, Ringnalda F, Villiger L, Siebenhüner A, Karkampouna S, De Menna M, Beshay J, Klett H, Kruithof-de Julio M, Schüler J, Schwank G.   +23 more
europepmc   +3 more sources

Identifying the prevalence of clinically actionable drug-gene interactions in a health system biorepository to guide pharmacogenetics implementation services. [PDF]

Clin Transl Sci, 2023
Pasternak AL, Ward K, Irwin M, Okerberg C, Hayes D, Fritsche L, Zoellner S, Virzi J, Choe HM, Ellingrod V.   +9 more
europepmc   +1 more source

Role of Drug-Gene Interactions and Pharmacogenetics in Simvastatin-Associated Pulmonary Toxicity. [PDF]

Drug Saf, 2021
Jessurun NT, Drent M, Wijnen PA, Harmsze AM, van Puijenbroek EP, Bekers O, Bast A.   +6 more
europepmc   +1 more source

Pharmacist assessment of drug-gene interactions and drug-induced phenoconversion in major depressive disorder: a case report. [PDF]

BMC Psychiatry, 2022
Del Toro-Pagán NM, Matos A, Bardolia C, Michaud V, Turgeon J, Amin NS.   +5 more
europepmc   +1 more source

Investigation into drug resistance to cisplatin in cancer stem cell-enriched population in non-small cell lung cancer

Türk Biyokimya Dergisi
Understanding drug resistance in cancer is of importance in treatment. Cancer stem cells are main factor for drug resistance. Therefore, the possible gene/gene interactions/proteins were explored in our study using a cancer stem cell-enriched population (
Dere Egemen, Akgün Oğuzhan, Aztopal Nazlıhan, Ulukaya Engin   +3 more
doaj   +1 more source

Lay understandings of drug-gene interactions: The right medication, the right dose, at the right time, but what are the right words? [PDF]

Clin Transl Sci, 2022
Meagher KM, Stuttgen Finn K, Curtis SH, Borucki J, Beck AT, Cheema AW, Sharp RR.   +6 more
europepmc   +1 more source

Sub-Analysis of CYP-GUIDES Data: Assessing the Prevalence and Impact of Drug-Gene Interactions in an Ethnically Diverse Cohort of Depressed Individuals. [PDF]

Front Pharmacol, 2022
Crutchley RD, Keuler N.
europepmc   +1 more source

ACE2 Netlas: In silico Functional Characterization and Drug-Gene Interactions of ACE2 Gene Network to Understand Its Potential Involvement in COVID-19 Susceptibility. [PDF]

Front Genet, 2021
Pathak GA, Wendt FR, Goswami A, Koller D, De Angelis F, COVID-19 Host Genetics Initiative, Polimanti R.   +6 more
europepmc   +1 more source

Biomarker-Based Prediction of OATP1B1 Activity in Clinical Routine-Investigating Coproporphyrins as Markers for Drug-Drug-Gene Interactions. [PDF]

Clin Pharmacol Ther
Potzel L, Zumtaugwald A, Bollinger A, Jeiziner C, Hersberger KE, Wiss F, Lampert ML, Allemann SS, Meyer Zu Schwabedissen HE, Stäuble CK.   +9 more
europepmc   +1 more source

Drug-drug-gene interactions as mediators of adverse drug reactions to diclofenac and statins: a case report and literature review. [PDF]

Arh Hig Rada Toksikol, 2021
Božina N, Ganoci L, Simičević L, Gvozdanović K, Domjanović IK, Fistrek Prlić M, Križ T, Borić Bilušić A, Laganović M, Božina T.   +9 more
europepmc   +1 more source