Results 41 to 50 of about 7,295,578 (250)
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Beni-Suef University Journal of Basic and Applied Sciences, 2021 Background Frontotemporal dementia (FTD) is the second most common type of dementia in individuals aged below 65 years with no current cure. Current treatment plan is the administration of multiple medications.
Archana Balasubramanian +2 more
doaj +1 more source
, 2016 data for Fig.5: gene-fam-with-drug-target.txt column 1: HGNC gene family ID or name column 2: number of drug target genes (gene products) in the (HGNC) gene family column 3: number of genes in the (HGNC) gene family (possibly including pseudogenes ...
Wentian Li (28857) +5 more
core +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
DiabetologyMetabolic syndrome (MetS) presents a significant global health challenge, characterized by a cluster of metabolic alterations including obesity, hypertension, insulin resistance/dysglycemia, and atherogenic dyslipidemia.
Sandra Knežević +5 more
doaj +1 more source
Dendrimers in drug delivery and targeting: Drug-dendrimer interactions and toxicity issues
Journal of Pharmacy and Bioallied Sciences, 2014 Dendrimers are the emerging polymeric architectures that are known for their defined structures, versatility in drug delivery and high functionality whose properties resemble with biomolecules.
Kanika Madaan +4 more
doaj +1 more source
The processes of reform in Victoria’s alcohol and other drug sector, 2011-2014 [PDF]
, 2014 This paper explores issues and concerns related to the 2014 alcohol and other drug sector recommissioning process in Victoria. Overview In mid-2014, the Victorian Alcohol and Drug Association approached the Drug Policy Modelling Program, at the ...
Drug Policy Modelling Program
core
Hospital drug safety - role of the pharmacists [PDF]
, 2005 Medication errors and adverse drug reactions are frequent in hospitalized patients. The principle aim of my dissertation was to review the existing data about frequency and risk factors of these findings and to propose measures for their reduction ...
Krähenbühl-Melcher, Anita Maria
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source