Results 41 to 50 of about 7,761,768 (249)

Prediction of drug-drug interactions from chemogenomic and gene-gene interactions and analysis of drug-drug interactions [PDF]

, 2013
The interactions between multiple drugs administered to an organism concurrently, whether in the form of synergy or antagonism, are of clinical relevance.
Akhmetov, Azat
core   +1 more source

Learning Petri net models of non-linear gene interactions [PDF]

, 2005
Understanding how an individual's genetic make-up influences their risk of disease is a problem of paramount importance. Although machine-learning techniques are able to uncover the relationships between genotype and disease, the problem of automatically
Mayo, Michael
core   +1 more source

Expression of drug transporters in intestine and blood [PDF]

, 2005
Proteins that are capable to transport molecules across membranes are fundamental for the accurate functioning of the body. Many diseases have their cause in a dysfunction of a particular transport protein.
Zimmermann, Christian
core   +1 more source

Drug-gene interactions and drug-gene-drug interactions: advancing to optimizing pharmacotherapy in clinical practice

Vitae
Drug interactions are quantitative changes in the intensity or duration of a drug's effect that may result in therapeutic failure or adverse effects due to: (a) the previous or concomitant use of another drug, herbal medicinal product, or food; (b ...
Pedro Amariles
doaj   +1 more source

Xprediction: Explainable EGFR-TKIs response prediction based on drug sensitivity specific gene networks.

PLoS ONE, 2022
In recent years, drug sensitivity prediction has garnered a great deal of attention due to the growing interest in precision medicine. Several computational methods have been developed for drug sensitivity prediction and the identification of related ...
Heewon Park, Rui Yamaguchi, Seiya Imoto, Satoru Miyano   +3 more
doaj   +1 more source

DataSheet1_Cost-Effectiveness of Pharmacogenomics-Guided Prescribing to Prevent Gene-Drug-Related Deaths: A Decision-Analytic Model.pdf

, 2022
Aim: Prospective studies support the clinical impact of pharmacogenomics (PGx)-guided prescribing to reduce severe and potentially fatal adverse effects.
Heiralde Marck (12966755), Henk-Jan Guchelaar (78210), Cathelijne H. van der Wouden (12966752), Jesse J. Swen (9408830), Wilbert B. van den Hout (8882162)   +4 more
core   +1 more source

Potential Breast Anticancer Drug Targets Revealed by Differential Gene Regulatory Network Analysis and Molecular Docking: Neoadjuvant Docetaxel Drug as a Case Study

Cancer Informatics, 2018
Understanding gene-gene interaction and its causal relationship to protein-protein interaction is a viable route for understanding drug action at the genetic level, which is largely hindered by inability to robustly map gene regulatory networks. Here, we
Adel Aloraini, Karim M ElSawy
doaj   +1 more source

Potential drug interactions : exposure and management in hospital and ambulatory settings [PDF]

, 2006
Health care professionals are responsible to ensure safe dispensing and use of drug regimens involving the use of drug combinations that may interact and cause serious adverse events.
Indermitte, Jörg Lorenz
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source