Frontiers in Psychiatry, 2021 Introduction: Polypharmacy and genetic variants that strongly influence medication response (pharmacogenomics, PGx) are two well-described risk factors for adverse drug reactions.
Sam Mostafa +2 more
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Factors Influencing Phenoconversion in CYP-Mediated Drug Metabolism: A Scoping Review [PDF]
PharmacyPharmacogenetics (PGx) aims to optimize drug therapy by predicting medication response based on genetic variation in drug-metabolizing enzymes. However, observed drug metabolism may differ from genotype-predicted metabolizer status given external or ...
Sierra Scodellaro +2 more
doaj +3 more sources
Pharmacogenetics and phenoconversion: the influence on side effects experienced by psychiatric patients [PDF]
Frontiers in Genetics, 2023 Introduction: Preventing side effects is important to ensure optimal psychopharmacotherapy and therapeutic adherence among psychiatric patients. Obtaining the pharmacogenetic profile of CYP2C19 and CYP2D6 can play an important role in this.
Manon G. den Uil +9 more
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CD4+ T-cell transcription factors predict phenoconversion in idiopathic rapid eye movement sleep behavior disorder [PDF]
Future Science OAAim: Early biomarkers of phenoconversion to neurodegeneration are crucial to identify individuals at high risk. In patients with idiopathic REM sleep behavior disorder (iRBD), the strongest risk factor for neurodegeneration, CD4+ T cells exhibit a ...
Michele Terzaghi +2 more
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The Evaluation of CYP2D6, CYP2C9, CYP2C19, and CYP2B6 Phenoconversion in Post-Mortem Casework: The Challenge of Forensic Toxicogenetics [PDF]
Metabolites, 2023 In toxicogenetics, an integrative approach including the prediction of phenotype based on post-mortem genotyping of drug-metabolising enzymes might help explain the cause of death (CoD) and manner of death (MoD).
Arianna Giorgetti +7 more
doaj +2 more sources
Inflammation-mediated Phenoconversion: A Potential Threat to COVID-19 Pharmacotherapy [PDF]
Hayati Journal of Biosciences, 2021 One of the important hallmarks of coronavirus disease 2019 (COVID-19) is the existence of severe inflammatory responses. Many reports indicated that inflammatory mediators might suppress the biological functions of some drug metabolizing enzymes and ...
Muh. Akbar Bahar +3 more
doaj +3 more sources
CXC-type chemokines promote myofibroblast phenoconversion and prostatic fibrosis. [PDF]
PLoS ONE, 2012 Recent studies from our group suggest that extracellular matrix (ECM) deposition and fibrosis characterize the peri-urethral prostate tissues of some men suffering from Lower Urinary Tract Symptoms (LUTS) and that fibrosis may be a contributing factor to
Mehrnaz Gharaee-Kermani +5 more
doaj +2 more sources
CXCL12/CXCR4 Axis Activation Mediates Prostate Myofibroblast Phenoconversion through Non-Canonical EGFR/MEK/ERK Signaling. [PDF]
PLoS ONE, 2016 Benign prostate hyperplasia (BPH), an enlargement of the prostate common in aging in men, is associated with urinary voiding dysfunction manifest as Lower Urinary Tract Symptoms (LUTS).
José A Rodríguez-Nieves +4 more
doaj +2 more sources
Association of wearable sensor-based gait analysis with phenoconversion trajectories in idiopathic REM sleep behavior disorder [PDF]
npj Parkinson's DiseaseIdiopathic rapid eye movement sleep behavior disorder (iRBD) is a well-established prodromal manifestation of α-synucleinopathies, with two principal phenoconversion trajectories: parkinsonism-first and dementia-first.
Shanshan Cen +7 more
doaj +2 more sources
The impact of CYP2C19 genotype on phenoconversion by concomitant medication
Frontiers in Pharmacology, 2023 Introduction: Pharmacogenetics-informed drug prescribing is increasingly applied in clinical practice. Typically, drug metabolizing phenotypes are determined based on genetic test results, whereupon dosage or drugs are adjusted.
Jesse J Swen +2 more
exaly +3 more sources