Pharmacogenetics and Phenoconversion: The Influence on Side Effects Experienced by Psychiatric Patients [PDF]
Frontiers in Genetics, 2023 Introduction: Preventing side effects is important to ensure optimal psychopharmacotherapy and therapeutic adherence among psychiatric patients. Obtaining the pharmacogenetic profile of CYP2C19 and CYP2D6 can play an important role in this.
Wiepke Cahn, Manon G Den Uil
exaly +11 more sources
Frontiers in Psychiatry, 2021 Introduction: Polypharmacy and genetic variants that strongly influence medication response (pharmacogenomics, PGx) are two well-described risk factors for adverse drug reactions.
Sam Mostafa +2 more
exaly +4 more sources
Factors Influencing Phenoconversion in CYP-Mediated Drug Metabolism: A Scoping Review [PDF]
PharmacyPharmacogenetics (PGx) aims to optimize drug therapy by predicting medication response based on genetic variation in drug-metabolizing enzymes. However, observed drug metabolism may differ from genotype-predicted metabolizer status given external or ...
Sierra Scodellaro +2 more
doaj +3 more sources
Drug-Induced CYP2D6 Phenoconversion Among Individuals with a Psychiatric Disorder: Prevalence and Association with Psychological Distress [PDF]
PharmaceuticsBackground/Objectives: Phenoconversion extends pharmacogenomics beyond genetic variation by accounting for non-genetic factors that can also dynamically alter metabolism, influence treatment response, adverse effect risk and overall patient outcomes ...
Ellen R. Mason +7 more
doaj +2 more sources
Phenoconversion and rural pain inequities: a precision-informed roadmap to advance equity for rural older adults [PDF]
Frontiers in Pain ResearchInequities in geriatric pain management persist despite three decades of research, disproportionately affecting older adults in rural communities.
Alexis K. Hall +3 more
doaj +2 more sources
Beyond Genotype: Integrating Phenoconversion into Pharmacogenetic Decision-Making in Psychiatry [PDF]
PharmaceuticalsInterindividual variability in psychotropic drug response contributes to treatment failure, adverse drug reactions, and repeated medication adjustments. Pharmacogenetics supports precision prescribing by identifying genetic variants associated with drug ...
Tiziano Prodi +7 more
doaj +2 more sources
Association of wearable sensor-based gait analysis with phenoconversion trajectories in idiopathic REM sleep behavior disorder [PDF]
npj Parkinson's DiseaseIdiopathic rapid eye movement sleep behavior disorder (iRBD) is a well-established prodromal manifestation of α-synucleinopathies, with two principal phenoconversion trajectories: parkinsonism-first and dementia-first.
Shanshan Cen +7 more
doaj +2 more sources
CYP2D6 as an Emerging Endogenous Oxidative Stress Modulator in Cardiovascular Disease: Genetic, Pharmacological, and Redox Perspectives [PDF]
AntioxidantsOxidative stress is a central and well-established driver of cardiovascular disease, contributing to mitochondrial dysfunction, endothelial injury, inflammatory activation, and progressive myocardial and vascular remodeling. Although the major endogenous
Cheng-Wu Yang +2 more
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Dynamic phenotype monitoring to prevent genotype–phenotype discrepancies in pharmacogenetic-guided drug therapy [PDF]
Frontiers in PharmacologyBackgroundOne of the limiting factors for the clinical application of pharmacogenomics (PGx) is phenoconversion, i.e., the dynamic discrepancy between genotype-predicted and actual drug-metabolizing phenotypes.
Pálma Porrogi
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Presymptomatic Amyotrophic Lateral Sclerosis: From Early Biomarker Detection to Phenoconversion Prediction [PDF]
DiagnosticsAmyotrophic lateral sclerosis (ALS) usually enters diagnostic pathways after motor symptoms emerge, by which time neural injury has been ongoing. Long-term hereditary ALS cohorts show that some pathogenic-variant carriers may show elevated neurofilament ...
Min Chen, Hexian Li, Qingwen Jin
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