Results 1 to 10 of about 2,106 (148)

Phenoconversion of Cytochrome P450 Metabolism: A Systematic Review [PDF]

Journal of Clinical Medicine, 2020
Phenoconversion is the mismatch between the individual’s genotype-based prediction of drug metabolism and the true capacity to metabolize drugs due to nongenetic factors.
Sylvia D Klomp, Martijn L Manson, Henk-Jan Guchelaar   +2 more
exaly   +8 more sources

Pharmacogenetics and phenoconversion: the influence on side effects experienced by psychiatric patients [PDF]

Frontiers in Genetics, 2023
Introduction: Preventing side effects is important to ensure optimal psychopharmacotherapy and therapeutic adherence among psychiatric patients. Obtaining the pharmacogenetic profile of CYP2C19 and CYP2D6 can play an important role in this.
Wiepke Cahn, Ingeborg Wilting, Vera H M Deneer   +2 more
exaly   +9 more sources

Clinical effects of CYP2D6 phenoconversion in patients with psychosis

Journal of Psychopharmacology
Background: Pharmacogenetics is considered a promising avenue for improving treatment outcomes, yet evidence arguing for the use of pharmacogenetics in the treatment of psychotic disorders is mixed and clinical usefulness is under debate.
Emma Y De Brabander, , Roos Van Westrhenen   +2 more
exaly   +5 more sources

Multimodal Autonomic Biomarkers Predict Phenoconversion in Pure Autonomic Failure. [PDF]

Ann Clin Transl Neurol
Background: Pure autonomic failure (PAF) presents with autonomic failure without other neurological features. A third develop central neurological features, fulfilling criteria for multiple system atrophy (MSA) and Lewy body diseases (LBD), including ...
Koay S, Vichayanrat E, Bremner F, Valerio F, Mackenzie R, Chiaro G, Ingle G, McNamara P, Watson L, Panicker JN, Lunn MP, Mathias C, Iodice V.   +12 more
europepmc   +4 more sources

The Evaluation of CYP2D6, CYP2C9, CYP2C19, and CYP2B6 Phenoconversion in Post-Mortem Casework: The Challenge of Forensic Toxicogenetics [PDF]

Metabolites, 2023
In toxicogenetics, an integrative approach including the prediction of phenotype based on post-mortem genotyping of drug-metabolising enzymes might help explain the cause of death (CoD) and manner of death (MoD).
Arianna Giorgetti, Sara Amurri, Carla Bini   +2 more
exaly   +2 more sources

Derivation and Validation of a Phenoconversion‐Related Pattern in Idiopathic Rapid Eye Movement Behavior Disorder [PDF]

Movement Disorders, 2023
Background: Idiopathic rapid eye movement sleep behavior disorder (iRBD) represents the prodromal stage of α-synucleinopathies. Reliable biomarkers are needed to predict phenoconversion.
Pietro Mattioli, Beatrice Orso, Claudio Liguori   +2 more
exaly   +3 more sources

Quantifying the Impact of Phenoconversion on Medications With Actionable Pharmacogenomic Guideline Recommendations in an Acute Aged Persons Mental Health Setting

Frontiers in Psychiatry, 2021
Introduction: Polypharmacy and genetic variants that strongly influence medication response (pharmacogenomics, PGx) are two well-described risk factors for adverse drug reactions.
Sam Mostafa, Thomas M Polasek, Carl M J Kirkpatrick   +2 more
exaly   +2 more sources

Effect of Individual and Combined Cytochrome P450 Activity Scores on Symptom Improvement and Side Effects in Youth Treated With Sertraline. [PDF]

Clin Transl Sci
ABSTRACT Sertraline is commonly used to treat mental health conditions in youth. However, its tolerability and efficacy vary between individuals, partly due to interindividual differences in drug metabolism. This study assessed the individual and combined impact of genetic variation in cytochrome P450 drug‐metabolizing enzymes on patient‐reported side ...
Gerlach S, Maruf AA, Shaheen SM, McCloud R, Heintz M, McAusland L, Arnold PD, Bousman CA.   +7 more
europepmc   +2 more sources

Serum p-tau217 Is a Prognostic Indicator of Cognitive Impairment in Idiopathic REM Sleep Behavior Disorder. [PDF]

Ann Neurol
Objective Assess the performance of serum phosphorylated tau 217 (p‐tau217) and neurofilament light chain (NfL) in predicting risk of cognitive impairment or phenoconversion to dementia in individuals with iRBD. Methods We measured serum p‐tau217 and NfL levels by electrochemiluminescence across 4 polysomnographically confirmed iRBD cohorts (n = 300 ...
Yan S, Sahoo A, Zerenner T, Marek K, Sommerauer M, Oertel W, Hu MT, Tofaris GK.   +7 more
europepmc   +2 more sources

CD4+ T-cell transcription factors predict phenoconversion in idiopathic rapid eye movement sleep behavior disorder [PDF]

Future Science OA
Aim: Early biomarkers of phenoconversion to neurodegeneration are crucial to identify individuals at high risk. In patients with idiopathic REM sleep behavior disorder (iRBD), the strongest risk factor for neurodegeneration, CD4+ T cells exhibit a ...
Michele Terzaghi, Franca Marino, Cristoforo Comi   +2 more
exaly   +2 more sources