Frontiers in Genetics, 2023 Introduction: Preventing side effects is important to ensure optimal psychopharmacotherapy and therapeutic adherence among psychiatric patients. Obtaining the pharmacogenetic profile of CYP2C19 and CYP2D6 can play an important role in this.
Wiepke Cahn +2 more
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Multimodal Autonomic Biomarkers Predict Phenoconversion in Pure Autonomic Failure [PDF]
Annals of Clinical and Translational NeurologyBackground Pure autonomic failure (PAF) presents with autonomic failure without other neurological features. A third develop central neurological features, fulfilling criteria for multiple system atrophy (MSA) and Lewy body diseases (LBD), including ...
S. Koay +12 more
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Frontiers in Psychiatry, 2021 Introduction: Polypharmacy and genetic variants that strongly influence medication response (pharmacogenomics, PGx) are two well-described risk factors for adverse drug reactions.
Sam Mostafa +2 more
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Association of wearable sensor-based gait analysis with phenoconversion trajectories in idiopathic REM sleep behavior disorder [PDF]
npj Parkinson's DiseaseIdiopathic rapid eye movement sleep behavior disorder (iRBD) is a well-established prodromal manifestation of α-synucleinopathies, with two principal phenoconversion trajectories: parkinsonism-first and dementia-first.
Shanshan Cen +7 more
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Pedunculopontine-thalamic cholinergic projections in rapid eye movement sleep behaviour disorder [PDF]
npj Parkinson's DiseaseCholinergic system degeneration is a hallmark of Lewy body disease, including Parkinson’s disease (PD) and dementia with Lewy bodies (DLB), but its involvement in prodromal stages, particularly regarding pedunculopontine-thalamic projections, remains ...
Julia Schumacher +3 more
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Susceptibility and diffusion MRI biomarkers predict development of Parkinsonism in iRBD [PDF]
npj Parkinson's DiseaseQuantitative MRI techniques, including quantitative susceptibility mapping (QSM) and diffusion tensor imaging (DTI), may detect early neurodegenerative changes in ɑ-synucleinopathies, especially within the midbrain.
Zsoka Varga +8 more
doaj +2 more sources
Gait dysfunction as an early marker of phenoconversion in REM sleep behavior disorder [PDF]
Scientific ReportsClinical isolated REM Sleep Behavior Disorder (iRBD) is a prodromal stage of α-synucleinopathies such as Parkinson’s disease (PD). Longitudinal changes of gait as a marker of phenoconversion in iRBD have not been systematically evaluated yet.
Wiebke Hermann +9 more
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CD4+ T-cell transcription factors as early predictors of phenoconversion in idiopathic rapid eye movement sleep behaviour disorder [version 2; peer review: 2 approved] [PDF]
F1000ResearchIn this datanote we present data from 31 iRBD (idiopathic Rapid eye movement (REM) sleep Behaviour Disorder) patients followed throughout three years to assess their eventual phenoconversion to Parkinson’s disease and other established neurodegenerative ...
Maurizio Versino +5 more
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From Genotype to Functional Risk: A Multi-Omic Approach to Predicting Thiopurine and Methotrexate Co-Therapy-Induced Liver Injury [PDF]
PharmaceuticalsThe combination of thiopurine and methotrexate (MTX) is a standard co-therapy regimen for acute lymphoblastic leukemia (ALL). Despite its efficacy, this regimen is constrained by a narrow therapeutic window and considerable inter-individual variability ...
Dénes Molnár +2 more
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Clinical and Translational SciencePhenoconversion is the discrepancy between genotype‐predicted phenotype and clinical phenotype, due to nongenetic factors. In oncology patients, the impact of phenoconversion on drug selection, efficacy, toxicity, and treatment outcomes is unknown.
Andreas Halman +2 more
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