Results 11 to 20 of about 2,455 (143)

Dynamic phenotype monitoring to prevent genotype–phenotype discrepancies in pharmacogenetic-guided drug therapy [PDF]

Frontiers in Pharmacology
BackgroundOne of the limiting factors for the clinical application of pharmacogenomics (PGx) is phenoconversion, i.e., the dynamic discrepancy between genotype-predicted and actual drug-metabolizing phenotypes.
Pálma Porrogi
doaj   +2 more sources

Pedunculopontine-thalamic cholinergic projections in rapid eye movement sleep behaviour disorder [PDF]

npj Parkinson's Disease
Cholinergic system degeneration is a hallmark of Lewy body disease, including Parkinson’s disease (PD) and dementia with Lewy bodies (DLB), but its involvement in prodromal stages, particularly regarding pedunculopontine-thalamic projections, remains ...
Julia Schumacher, Stefan Teipel, Alexander Storch, Wiebke Hermann   +3 more
doaj   +2 more sources

Synergistic Effects of Inflammation and Drug Interactions on CYP3A5*3/*3 Phenoconversion in Antipsychotic Metabolism [PDF]

Pharmaceutics
Background: Traditional genotype-guided dosing often fails to predict real-time variability in the metabolic phenotype during complex polypharmacy.
Krisztina Kőhalmy, Ayaan Borthakur, Pálma Porrogi   +2 more
doaj   +2 more sources

Multimodal Autonomic Biomarkers Predict Phenoconversion in Pure Autonomic Failure

Annals of Clinical and Translational Neurology
Background Pure autonomic failure (PAF) presents with autonomic failure without other neurological features. A third develop central neurological features, fulfilling criteria for multiple system atrophy (MSA) and Lewy body diseases (LBD), including ...
S. Koay, E. Vichayanrat, F. Bremner, F. Valerio, R. Mackenzie, G. Chiaro, G. Ingle, P. McNamara, L. Watson, J. N. Panicker, M. P. Lunn, C. Mathias, V. Iodice   +12 more
doaj   +3 more sources

Susceptibility and diffusion MRI biomarkers predict development of Parkinsonism in iRBD [PDF]

npj Parkinson's Disease
Quantitative MRI techniques, including quantitative susceptibility mapping (QSM) and diffusion tensor imaging (DTI), may detect early neurodegenerative changes in ɑ-synucleinopathies, especially within the midbrain.
Zsoka Varga, Jiri Nepozitek, Jan Hlavnicka, Jiri Keller, Abhineet Ojha, Patrizia Pantano, Stanislav Marecek, Karel Sonka, Petr Dusek   +8 more
doaj   +2 more sources

Gait dysfunction as an early marker of phenoconversion in REM sleep behavior disorder [PDF]

Scientific Reports
Clinical isolated REM Sleep Behavior Disorder (iRBD) is a prodromal stage of α-synucleinopathies such as Parkinson’s disease (PD). Longitudinal changes of gait as a marker of phenoconversion in iRBD have not been systematically evaluated yet.
Wiebke Hermann, Aleyna Sankutlu, Lydia Nabers, Tony Sehr, Katrin Trentzsch, Markus Donix, Heinz Reichmann, Moritz D. Brandt, Alexander Storch, Tjalf Ziemssen   +9 more
doaj   +2 more sources

From Genotype to Functional Risk: A Multi-Omic Approach to Predicting Thiopurine and Methotrexate Co-Therapy-Induced Liver Injury [PDF]

Pharmaceuticals
The combination of thiopurine and methotrexate (MTX) is a standard co-therapy regimen for acute lymphoblastic leukemia (ALL). Despite its efficacy, this regimen is constrained by a narrow therapeutic window and considerable inter-individual variability ...
Dénes Molnár, Elizabeth Reznik, Pálma Porrogi   +2 more
doaj   +2 more sources

CD4+ T-cell transcription factors as early predictors of phenoconversion in idiopathic rapid eye movement sleep behaviour disorder [version 2; peer review: 2 approved] [PDF]

F1000Research
In this datanote we present data from 31 iRBD (idiopathic Rapid eye movement (REM) sleep Behaviour Disorder) patients followed throughout three years to assess their eventual phenoconversion to Parkinson’s disease and other established neurodegenerative ...
Maurizio Versino, Cristoforo Comi, Franca Marino, Michele Terzaghi, Monica Pinoli, Marco Cosentino   +5 more
doaj   +2 more sources

Factors associated with phenoconversion of idiopathic rapid eye movement sleep behavior disorder: a prospective study

npj Parkinson's Disease
This study explores the effect of risk factors on the progression of idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) to α-synucleinopathies in a Chinese cohort.
Yuan Yuan, Yuan Li, Hui Zhang, Yajie Zang, Xiaonan Liu, Yue Hou, Shuqin Zhan, Yanning Cai, Wei Mao, Piu Chan   +9 more
doaj   +2 more sources

Case report: Therapeutic drug monitoring and CYP2D6 phenoconversion in a protracted paroxetine intoxication

Frontiers in Pharmacology
ObjectiveThe cytochrome P450 2D6 (CYP2D6) is an enzyme involved in the oxidative biotransformation of various widely used drugs, including paroxetine, a substrate and strong inhibitor of the enzyme.
Alena Damborská
exaly   +3 more sources