Results 11 to 20 of about 2,106 (148)

Inflammation-mediated Phenoconversion: A Potential Threat to COVID-19 Pharmacotherapy

HAYATI Journal of Biosciences, 2021
One of the important hallmarks of coronavirus disease 2019 (COVID-19) is the existence of severe inflammatory responses. Many reports indicated that inflammatory mediators might suppress the biological functions of some drug metabolizing enzymes and ...
Nainu, Firzan, Harapan Harapan, Wilffert, Bob, Muh. Akbar Bahar, Bob Wilffert, Firzan Nainu, Bahar, Muh. Akbar, Harapan, Harapan, Akbar Bahar, Muh   +8 more
core   +4 more sources

The impact of CYP2C19 genotype on phenoconversion by concomitant medication [PDF]

Frontiers in Pharmacology, 2023
Introduction: Pharmacogenetics-informed drug prescribing is increasingly applied in clinical practice. Typically, drug metabolizing phenotypes are determined based on genetic test results, whereupon dosage or drugs are adjusted.
Maarten E. Tushuizen, Lukas J. A. C. Hawinkels, Martijn L. Manson, Menno Hoekstra, Martin Giera, Soukayna Boussallami, Elena Sánchez-López, Robert Rissmann, Laura M. de Jong, Jesse J. Swen   +9 more
core   +11 more sources

Validation of the REM behaviour disorder phenoconversion-related pattern in an independent cohort [PDF]

Neurological Sciences, 2023
Background A brain glucose metabolism pattern related to phenoconversion in patients with idiopathic/isolated REM sleep behaviour disorder (iRBDconvRP) was recently identified.
Liguori C., Pardini M., Kim H., Arnaldi D., Mattioli P., García D. V., Donniaquio A., Meles S. K., Massa F., Nobili F., Bauckneht M., Orso B., Yoon E. J., Shin J. H., Famà F., Morbelli S., Chiaravalloti A., Kim Y. K., Kim R., Leenders K. L., Lee J. Y.   +20 more
core   +6 more sources

‘Phenoconversion’ in adult patients with β‐thalassemia

American Journal of Hematology
: Rate and risk factors for phenoconversion from non-transfusion-dependent β-thalassemia (NTDT) to transfusion-dependent β-thalassemia (TDT) during a 10-year follow up of adult patients in ...
Barella, Susanna, Lisi, Roberto, Pasanisi, Annamaria, Lucia De Franceschi, Domenico Roberti, Martina Culcasi, Ferrero, Giovanni Battista, Gianesin, Barbara, Musallam, Khaled M., Origa, Raffaella, Valeria Pinto, Longo, Filomena, Forni, Gian Luca, Roberta Sciortino   +13 more
core   +5 more sources

Relationship of Mediterranean diet and caloric intake to phenoconversion in Huntington disease [PDF]

JAMA Neurology, 2013
IMPORTANCE: Adherence to Mediterranean-type diet (MeDi) may delay onset of Alzheimer and Parkinson diseases. Whether adherence to MeDi affects time to phenoconversion in Huntington disease (HD), a highly penetrant, single-gene disorder, is unknown ...
Eberly, S., Shoulson, I., Marder, K., Scarmeas, N., Tanner, C.M., Oakes, D., Gu, Y.   +6 more
core   +8 more sources

CXC-type chemokines promote myofibroblast phenoconversion and prostatic fibrosis.

PLoS ONE, 2012
Recent studies from our group suggest that extracellular matrix (ECM) deposition and fibrosis characterize the peri-urethral prostate tissues of some men suffering from Lower Urinary Tract Symptoms (LUTS) and that fibrosis may be a contributing factor to
Mehrnaz Gharaee-Kermani (118877), Sathish Kasina (118881), Jill A Macoska, Dafydd Thomas (118889), Dafydd Thomas, Bethany B. Moore (118885), Rohit Mehra (118892), Jill A. Macoska (118895), Rohit Mehra, Mehrnaz Gharaee-Kermani, Sathish Kasina, Bethany B Moore   +11 more
core   +5 more sources

A retrotransposon storm marks clinical phenoconversion to late-onset Alzheimer's disease. [PDF]

GeroScience, 2022
Recent reports have suggested that the reactivation of otherwise transcriptionally silent transposable elements (TEs) might induce brain degeneration, either by dysregulating the expression of genes and pathways implicated in cognitive decline and ...
Gross, Thomas J., Taccioli, Cristian, Gusev, Yuriy, Gross, Thomas J, Fiandaca, Massimo S., Boattini, Alessio, Anderlucci, Laura, Padilla, Robert M, Modenini, Giorgia, Fiandaca, Massimo S, Guffanti, Guia, Malhas, Rond, Macciardi, Fabio, Padilla, Robert M., Federoff, Howard J., Giulia Bacalini, Maria, Miramontes, Ricardo, Head, Elizabeth, Mapstone, Mark, Federoff, Howard J   +19 more
core   +6 more sources

Dasatinib-induced nephrotic syndrome: a case of phenoconversion?

Croatian Medical Journal, 2019
We present the case of a 33-year-old chronic myeloid leukemia (CML) female patient, in whom the occurrence of nephrotic syndrome, during the treatment with tyrosine kinase activity inhibitors (TKIs), was potentially influenced by transient ...
Matišić, Vid, Borna Arsov, Mandac Rogulj, Inga, Boban, Luka, Inga Mandac Rogulj, Primorac, Dragan, Arsov, Borna, Juginović, Alen, Vid Matišić, Alen Juginović, Vilim Molnar, Molnar, Vilim, Luka Boban, Dragan Primorac, Rogulj, Inga Mandac   +14 more
core   +7 more sources

Resveratrol-Mediated Repression and Reversion of Prostatic Myofibroblast Phenoconversion.

PLOS ONE, 2016
Resveratrol, a phytoalexin found in berries, peanuts, grapes, and red wine, inhibits oxidation, inflammation, and cell proliferation and collagen synthesis in multiple cell types and or animal models.
Jill A Macoska, Mehrnaz Gharaee-Kermani, Bethany B Moore   +2 more
core   +5 more sources

Predicting Phenoconversion in Isolated RBD: Machine Learning and Explainable AI Approach. [PDF]

Clocks Sleep
Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is recognized as a precursor to neurodegenerative diseases. This study aimed to develop predictive models for the timing and subtype of phenoconversion in iRBD.
Shin YW, Byun JI, Sunwoo JS, Rhee CS, Shin JH, Kim HJ, Jung KY.   +6 more
europepmc   +2 more sources