Results 11 to 20 of about 1,862 (162)

Inflammation-mediated Phenoconversion: A Potential Threat to COVID-19 Pharmacotherapy

Hayati Journal of Biosciences, 2021
One of the important hallmarks of coronavirus disease 2019 (COVID-19) is the existence of severe inflammatory responses. Many reports indicated that inflammatory mediators might suppress the biological functions of some drug metabolizing enzymes and ...
Muh. Akbar Bahar, Bob Wilffert, Harapan Harapan, Firzan Nainu   +3 more
doaj   +4 more sources

The impact of CYP2C19 genotype on phenoconversion by concomitant medication

Frontiers in Pharmacology, 2023
Introduction: Pharmacogenetics-informed drug prescribing is increasingly applied in clinical practice. Typically, drug metabolizing phenotypes are determined based on genetic test results, whereupon dosage or drugs are adjusted.
Laura M. de Jong, Soukayna Boussallami, Elena Sánchez-López, Martin Giera, Maarten E. Tushuizen, Menno Hoekstra, Lukas J. A. C. Hawinkels, Robert Rissmann, Robert Rissmann, Robert Rissmann, Jesse J. Swen, Martijn L. Manson   +11 more
doaj   +6 more sources

CXC-type chemokines promote myofibroblast phenoconversion and prostatic fibrosis. [PDF]

PLoS ONE, 2012
Recent studies from our group suggest that extracellular matrix (ECM) deposition and fibrosis characterize the peri-urethral prostate tissues of some men suffering from Lower Urinary Tract Symptoms (LUTS) and that fibrosis may be a contributing factor to
Mehrnaz Gharaee-Kermani, Sathish Kasina, Bethany B Moore, Dafydd Thomas, Rohit Mehra, Jill A Macoska   +5 more
doaj   +4 more sources

CD4+ T-cell transcription factors predict phenoconversion in idiopathic rapid eye movement sleep behavior disorder

Future Science OA
Aim: Early biomarkers of phenoconversion to neurodegeneration are crucial to identify individuals at high risk. In patients with idiopathic REM sleep behavior disorder (iRBD), the strongest risk factor for neurodegeneration, CD4+ T cells exhibit a ...
Michele Terzaghi, Cristoforo Comi, Marco Cosentino   +2 more
exaly   +3 more sources

Case report: Therapeutic drug monitoring and CYP2D6 phenoconversion in a protracted paroxetine intoxication

Frontiers in Pharmacology
ObjectiveThe cytochrome P450 2D6 (CYP2D6) is an enzyme involved in the oxidative biotransformation of various widely used drugs, including paroxetine, a substrate and strong inhibitor of the enzyme.
Alena Damborská, Damborská Alena
exaly   +3 more sources

Machine Learning Predicts Phenoconversion from Polysomnography in Isolated REM Sleep Behavior Disorder

Brain Sciences
Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is a prodromal stage of alpha-synucleinopathies. This study aimed at developing a fully-automated machine learning framework for the prediction of phenoconversion in patients with iRBD by ...
Matteo Cesari, Antonio Rodriguez-Sanchez, Birgit Högl   +2 more
exaly   +3 more sources

Predicting Phenoconversion in Isolated RBD: Machine Learning and Explainable AI Approach

Clocks & Sleep
Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is recognized as a precursor to neurodegenerative diseases. This study aimed to develop predictive models for the timing and subtype of phenoconversion in iRBD.
Yong-Woo Shin, Jung-Ick Byun, Jun-Sang Sunwoo, Chae-Seo Rhee, Jung-Hwan Shin, Han-Joon Kim, Ki-Young Jung   +6 more
doaj   +3 more sources

The Evaluation of CYP2D6, CYP2C9, CYP2C19, and CYP2B6 Phenoconversion in Post-Mortem Casework: The Challenge of Forensic Toxicogenetics

Metabolites, 2023
In toxicogenetics, an integrative approach including the prediction of phenotype based on post-mortem genotyping of drug-metabolising enzymes might help explain the cause of death (CoD) and manner of death (MoD).
Arianna Giorgetti, Sara Amurri, Giulia Fazio, Carla Bini, Laura Anniballi, Filippo Pirani, Guido Pelletti, Susi Pelotti   +7 more
doaj   +1 more source

CXCL12/CXCR4 Axis Activation Mediates Prostate Myofibroblast Phenoconversion through Non-Canonical EGFR/MEK/ERK Signaling. [PDF]

PLoS ONE, 2016
Benign prostate hyperplasia (BPH), an enlargement of the prostate common in aging in men, is associated with urinary voiding dysfunction manifest as Lower Urinary Tract Symptoms (LUTS).
José A Rodríguez-Nieves, Susan C Patalano, Diego Almanza, Mehrnaz Gharaee-Kermani, Jill A Macoska   +4 more
doaj   +1 more source

Unawareness of motor phenoconversion in Huntington disease [PDF]

Neurology, 2013
To determine whether Huntington disease (HD) mutation carriers have motor symptoms (complaints) when definite motor onset (motor phenoconversion) is diagnosed and document differences between the groups with and without unawareness of motor signs.We analyzed data from 550 HD mutation carriers participating in the multicenter PREDICT-HD Study followed ...
Elizabeth A, McCusker, David G, Gunn, Eric A, Epping, Clement T, Loy, Kylie, Radford, Jane, Griffith, James A, Mills, Jeffrey D, Long, Jane S, Paulsen   +8 more
openaire   +2 more sources