Inflammation-mediated Phenoconversion: A Potential Threat to COVID-19 Pharmacotherapy [PDF]
Hayati Journal of Biosciences, 2021 One of the important hallmarks of coronavirus disease 2019 (COVID-19) is the existence of severe inflammatory responses. Many reports indicated that inflammatory mediators might suppress the biological functions of some drug metabolizing enzymes and ...
Muh. Akbar Bahar +3 more
doaj +5 more sources
CXC-type chemokines promote myofibroblast phenoconversion and prostatic fibrosis. [PDF]
PLoS ONE, 2012 Recent studies from our group suggest that extracellular matrix (ECM) deposition and fibrosis characterize the peri-urethral prostate tissues of some men suffering from Lower Urinary Tract Symptoms (LUTS) and that fibrosis may be a contributing factor to
Mehrnaz Gharaee-Kermani +5 more
doaj +5 more sources
Multimodal Autonomic Biomarkers Predict Phenoconversion in Pure Autonomic Failure
Annals of Clinical and Translational NeurologyBackground Pure autonomic failure (PAF) presents with autonomic failure without other neurological features. A third develop central neurological features, fulfilling criteria for multiple system atrophy (MSA) and Lewy body diseases (LBD), including ...
S. Koay +12 more
doaj +5 more sources
Phenoconversion of CYP3A4, CYP2C19 and CYP2D6 in Pediatrics, Adolescents and Young Adults With Lymphoma: Rationale and Design of the PEGASUS Study [PDF]
Clinical and Translational SciencePhenoconversion is the discrepancy between genotype‐predicted phenotype and clinical phenotype, due to nongenetic factors. In oncology patients, the impact of phenoconversion on drug selection, efficacy, toxicity, and treatment outcomes is unknown.
Andreas Halman +2 more
exaly +4 more sources
The Evaluation of CYP2D6, CYP2C9, CYP2C19, and CYP2B6 Phenoconversion in Post-Mortem Casework: The Challenge of Forensic Toxicogenetics [PDF]
Metabolites, 2023 In toxicogenetics, an integrative approach including the prediction of phenotype based on post-mortem genotyping of drug-metabolising enzymes might help explain the cause of death (CoD) and manner of death (MoD).
Arianna Giorgetti +7 more
doaj +2 more sources
CXCL12/CXCR4 Axis Activation Mediates Prostate Myofibroblast Phenoconversion through Non-Canonical EGFR/MEK/ERK Signaling. [PDF]
PLoS ONE, 2016 Benign prostate hyperplasia (BPH), an enlargement of the prostate common in aging in men, is associated with urinary voiding dysfunction manifest as Lower Urinary Tract Symptoms (LUTS).
José A Rodríguez-Nieves +4 more
doaj +2 more sources
Brain SciencesIsolated rapid eye movement (REM) sleep behavior disorder (iRBD) is a prodromal stage of alpha-synucleinopathies. This study aimed at developing a fully-automated machine learning framework for the prediction of phenoconversion in patients with iRBD by ...
Matteo Cesari +2 more
exaly +4 more sources
Longitudinal plasma proteomics predict phenoconversion to clinically manifest ALS. [PDF]
Nat MedAbstract The study of pre-symptomatic amyotrophic lateral sclerosis (ALS) and the design of disease prevention trials are greatly hampered by our inability to predict which unaffected carriers of ALS-associated pathogenic variants will phenoconvert to clinically manifest disease and when.
Ran X +15 more
europepmc +6 more sources
The impact of CYP2C19 genotype on phenoconversion by concomitant medication
Frontiers in Pharmacology, 2023 Introduction: Pharmacogenetics-informed drug prescribing is increasingly applied in clinical practice. Typically, drug metabolizing phenotypes are determined based on genetic test results, whereupon dosage or drugs are adjusted.
Laura M. de Jong +11 more
doaj +6 more sources
‘Phenoconversion’ in adult patients with β‐thalassemia
American Journal of HematologyRate and risk factors for phenoconversion from non-transfusion-dependent β-thalassemia (NTDT) to transfusion-dependent β-thalassemia (TDT) during a 10-year follow up of adult patients in Italy.
Musallam, Khaled M. +13 more
openaire +5 more sources