Results 21 to 30 of about 2,663 (168)

Relationship of Mediterranean Diet and Caloric Intake to Phenoconversion in Huntington Disease [PDF]

JAMA Neurology, 2013
Adherence to Mediterranean-type diet (MeDi) may delay onset of Alzheimer and Parkinson diseases. Whether adherence to MeDi affects time to phenoconversion in Huntington disease (HD), a highly penetrant, single-gene disorder, is unknown.To determine if MeDi modifies the time to clinical onset of HD (phenoconversion) in premanifest carriers participating
Marder, Karen, Gu, Yian, Eberly, Shirley, Tanner, Caroline M, Scarmeas, Nikolaos, Oakes, David, Shoulson, Ira   +6 more
core   +9 more sources

A retrotransposon storm marks clinical phenoconversion to late-onset Alzheimer’s disease [PDF]

GeroScience, 2022
AbstractRecent reports have suggested that the reactivation of otherwise transcriptionally silent transposable elements (TEs) might induce brain degeneration, either by dysregulating the expression of genes and pathways implicated in cognitive decline and dementia or through the induction of immune-mediated neuroinflammation resulting in the ...
Macciardi, Fabio, Giulia Bacalini, Maria, Miramontes, Ricardo, Boattini, Alessio, Taccioli, Cristian, Modenini, Giorgia, Malhas, Rond, Anderlucci, Laura, Gusev, Yuriy, Gross, Thomas J, Padilla, Robert M, Fiandaca, Massimo S, Head, Elizabeth, Guffanti, Guia, Federoff, Howard J, Mapstone, Mark   +15 more
openaire   +6 more sources

Pedunculopontine-thalamic cholinergic projections in rapid eye movement sleep behaviour disorder [PDF]

npj Parkinson's Disease
Cholinergic system degeneration is a hallmark of Lewy body disease, including Parkinson’s disease (PD) and dementia with Lewy bodies (DLB), but its involvement in prodromal stages, particularly regarding pedunculopontine-thalamic projections, remains ...
Julia Schumacher, Stefan Teipel, Alexander Storch, Wiebke Hermann   +3 more
doaj   +2 more sources

Synergistic Effects of Inflammation and Drug Interactions on CYP3A5*3/*3 Phenoconversion in Antipsychotic Metabolism [PDF]

Pharmaceutics
Background: Traditional genotype-guided dosing often fails to predict real-time variability in the metabolic phenotype during complex polypharmacy.
Krisztina Kőhalmy, Ayaan Borthakur, Pálma Porrogi   +2 more
doaj   +2 more sources

Resveratrol-Mediated Repression and Reversion of Prostatic Myofibroblast Phenoconversion [PDF]

PLOS ONE, 2016
Resveratrol, a phytoalexin found in berries, peanuts, grapes, and red wine, inhibits oxidation, inflammation, and cell proliferation and collagen synthesis in multiple cell types and or animal models. It represses collagen deposition in the vasculature, heart, lung, kidney, liver, and esophagus in animal models and may have some utility as an anti ...
Mehrnaz Gharaee-Kermani, Bethany B Moore, Jill A Macoska   +2 more
openaire   +5 more sources

Gait dysfunction as an early marker of phenoconversion in REM sleep behavior disorder [PDF]

Scientific Reports
Clinical isolated REM Sleep Behavior Disorder (iRBD) is a prodromal stage of α-synucleinopathies such as Parkinson’s disease (PD). Longitudinal changes of gait as a marker of phenoconversion in iRBD have not been systematically evaluated yet.
Wiebke Hermann, Aleyna Sankutlu, Lydia Nabers, Tony Sehr, Katrin Trentzsch, Markus Donix, Heinz Reichmann, Moritz D. Brandt, Alexander Storch, Tjalf Ziemssen   +9 more
doaj   +2 more sources

From Genotype to Functional Risk: A Multi-Omic Approach to Predicting Thiopurine and Methotrexate Co-Therapy-Induced Liver Injury [PDF]

Pharmaceuticals
The combination of thiopurine and methotrexate (MTX) is a standard co-therapy regimen for acute lymphoblastic leukemia (ALL). Despite its efficacy, this regimen is constrained by a narrow therapeutic window and considerable inter-individual variability ...
Dénes Molnár, Elizabeth Reznik, Pálma Porrogi   +2 more
doaj   +2 more sources

microRNA-7-5p and α-Synuclein SAA Predict Parkinson's Disease Phenoconversion. [PDF]

Ann Clin Transl Neurol
ABSTRACT Objective Corroborate blood neuron‐derived extracellular vesicle (NDEV) alpha‐synuclein (αSyn), the CSF αSyn seed amplification assay (αSyn‐SAA), and blood microRNA‐7‐5p (miR‐7‐5p) as markers for Parkinson's disease (PD) phenoconversion and determine if combining these markers would help select subjects who would be more likely to phenoconvert.
Zadegan S, Velammal P, Muthiah K, Jatty M, Adams C.   +4 more
europepmc   +2 more sources

Case Report: Therapeutic Drug Monitoring and CYP2D6 Phenoconversion in a Protracted Paroxetine Intoxication

Frontiers in Pharmacology
ObjectiveThe cytochrome P450 2D6 (CYP2D6) is an enzyme involved in the oxidative biotransformation of various widely used drugs, including paroxetine, a substrate and strong inhibitor of the enzyme.
Katerina Horska, Alena Damborská
exaly   +3 more sources

Understanding variation in metoprolol response: CYP2D6, drug interactions, and phenoconversion

Pharmacogenomics
Metoprolol, a β1-selective blocker, is widely used for treating cardiovascular and non-cardiovascular conditions. Its pharmacokinetics (PK) and pharmacodynamics (PD) vary significantly between individuals, in part due to CYP2D6 genetic polymorphisms.
Bayan Azizi, David E. Lanfear, Jasmine A. Luzum   +2 more
openaire   +3 more sources