Results 21 to 30 of about 1,862 (162)

The Influence of Pharmacogenetics on the Clinical Relevance of Pharmacokinetic Drug–Drug Interactions: Drug–Gene, Drug–Gene–Gene and Drug–Drug–Gene Interactions

Pharmaceuticals, 2021
Drug interactions are a well-known cause of adverse drug events, and drug interaction databases can help the clinician to recognize and avoid such interactions and their adverse events. However, not every interaction leads to an adverse drug event.
Martina Hahn, Sibylle C. Roll
doaj   +1 more source

Personality profile and its association with conversion to neurodegenerative disorders in idiopathic REM sleep behavior disorder

npj Parkinson's Disease, 2022
Patients with Parkinson’s disease (PD) were described less extraverted and more neurotic. It remained unclear whether similar personality traits could be found in idiopathic rapid eye movement sleep behavior disorder (iRBD), a prodromal stage of PD, and ...
Li Zhou, Steven W. H. Chau, Yaping Liu, Jing Wang, Jihui Zhang, Ngan Yin Chan, Joey W. Y. Chan, Bei Huang, Sijing Chen, Shirley Xin Li, Vincent Chung Tong Mok, Yun Kwok Wing   +11 more
doaj   +1 more source

Predicting phenoconversion in pure autonomic failure

Neurology, 2020
To determine predicting factors and frequency of phenoconversion from pure autonomic failure (PAF) into a synucleinopathy with motor or cognitive involvement of multiple system atrophy (MSA), Parkinson disease (PD), or dementia with Lewy bodies (DLB).We performed a retrospective review of all patients with PAF from 2001 to 2011 evaluated at Mayo Clinic,
Elizabeth A, Coon, Jay N, Mandrekar, Sarah E, Berini, Eduardo E, Benarroch, Paola, Sandroni, Phillip A, Low, Wolfgang, Singer   +6 more
openaire   +3 more sources

Evaluation of changes in cytochrome P450 2C19 activity in type 2 diabetic rats before and after treatment, by using isolated perfused liver model [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): Alteration in drug metabolism is very likely in diabetes mellitus. This study assessed changes in CYP2C19 enzymatic activity in the liver using omeprazole as a probe in the animal model of type II diabetes (T2DM) before and after treatment ...
Navid Neyshaburinezhad, Mohammad Reza Rouini, Hanieh Entezari, Hoda Lavasani, Yalda Hosseinzadeh Ardakani   +4 more
doaj   +1 more source

Phenoconversion and therapeutic drug monitoring [PDF]

British Journal of Clinical Pharmacology, 2015
Keywords: clobazam; clozapine; genotype–phenotype mismatch; personalized medicine; pharmacogenetics; risperidone; therapeutic drug monitoring ...
openaire   +2 more sources

Pitfalls and challenges associated with phenoconversion in forensic toxcicology

Forensic Science International: Genetics, 2021
In recent years, several publications have demonstrated the interest and the usefulness of pharmacogenetics in forensic toxicology. However, this approach remains namely focused on DNA-based phenotype, which may potentially lead to misinterpretation.
Drevin, G., Picard, N., Jousset, N., Briet, M., Abbara, C.   +4 more
openaire   +3 more sources

Sleep Disturbances and Phenoconversion in Patients with REM Sleep Behavior Disorder [PDF]

Journal of Clinical Medicine, 2021
Objective: We aimed to investigate relationships between sleep disturbances and phenoconversion to neurodegenerative diseases in patients with REM sleep behavior disorder (RBD). Method: Using a comprehensive sleep database in a university-affiliated hospital between December 2014 and March 2021, we reviewed the data of 226 patients with RBD (182 ...
Hyunjin Jo, Dongyeop Kim, Jooyeon Song, Sujung Choi, Eunyeon Joo   +4 more
openaire   +2 more sources

Phenoconversion of CYP2D6 by inhibitors modifies aripiprazole exposure [PDF]

European Archives of Psychiatry and Clinical Neuroscience, 2019
The efficacy of aripiprazole therapy and the risk of adverse reactions are influenced by substantial inter-individual variability in aripiprazole metabolizing capacity. In vitro studies assigned the potential role in aripiprazole metabolism to CYP2D6 and CYP3A enzymes; therefore, the association between the steady-state aripiprazole plasma ...
Ádám Kiss, Ádám Menus, Katalin Tóth, Máté Déri, Dávid Sirok, Evelyn Gabri, Ales Belic, Gábor Csukly, István Bitter, Katalin Monostory   +9 more
openaire   +3 more sources

REM Sleep Behaviour Disorder in Multiple System Atrophy: From Prodromal to Progression of Disease

Frontiers in Neurology, 2021
A higher frequency of motor and breathing sleep-related disorders in multiple system atrophy (MSA) populations is reported. REM sleep behaviour disorder (RBD) is one of the most robust markers of an underlying alpha-synucleinopathy.
Giulia Giannini, Giulia Giannini, Federica Provini, Federica Provini, Pietro Cortelli, Pietro Cortelli, Giovanna Calandra-Buonaura, Giovanna Calandra-Buonaura   +7 more
doaj   +1 more source

Cardiosomal microRNAs Are Essential in Post-Infarction Myofibroblast Phenoconversion [PDF]

International Journal of Molecular Sciences, 2019
The inclusion of microRNAs (miRNAs) in extracellular microvesicles/exosomes (named cardiosomes when deriving from cardiomyocytes) allows their active transportation and ensures cell-cell communication. We hypothesize that cardiosomal miRNAs play a pivotal role in the activation of myofibroblasts following ischemic injury.
Morelli Marco Bruno, Shu J, Sardu Celestino, Matarese Alessandro, Santulli Gaetano   +4 more
openaire   +5 more sources