Results 21 to 30 of about 2,455 (143)

Machine Learning Predicts Phenoconversion from Polysomnography in Isolated REM Sleep Behavior Disorder

Brain Sciences
Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is a prodromal stage of alpha-synucleinopathies. This study aimed at developing a fully-automated machine learning framework for the prediction of phenoconversion in patients with iRBD by ...
Matteo Cesari, Antonio Rodriguez-Sanchez, Birgit Högl   +2 more
exaly   +3 more sources

Predicting Phenoconversion in Isolated RBD: Machine Learning and Explainable AI Approach

Clocks & Sleep
Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is recognized as a precursor to neurodegenerative diseases. This study aimed to develop predictive models for the timing and subtype of phenoconversion in iRBD.
Ki-Young Jung, Han-Joon Kim, Jun-Sang Sunwoo   +2 more
exaly   +3 more sources

Dopaminergic damage pattern predicts phenoconversion time in isolated rapid eye movement sleep behavior disorder [PDF]

, 2023
PURPOSE The exact phenoconversion time from isolated rapid eye movement (REM) sleep behavior disorder (iRBD) to synucleinopathies remains unpredictable. This study investigated whole-brain dopaminergic damage pattern (DDP) with disease progression and
Lin, Huamei, Shujun Zhao, Tianhao Zhang, Zhao, Shilun, Li, Xiuming, Shi, Kuangyu, Guan, Yihui, Ping Wu, Yihui Guan, Shuang Feng, Jianjun Wu, Binbin Nie, Shan, Baoci, Xu, Qian, Zhang, Tianhao, Shilun Zhao, Zuo, Chuantao, Xiuming Li, Chuantao Zuo, Baoci Shan, Huan Yu, Wu, Jianjun, Feng, Shuang, Ge, Jingjie, Huamei Lin, Yu, Huan, Jingjie Ge, Qian Xu, Zhao, Shujun, Wu, Ping, Kuangyu Shi, Nie, Binbin   +31 more
core   +2 more sources

Progression of Motor and Cognitive Functions in Isolated REM Sleep Behavior Disorder: A 7-Year Prospective Matched Cohort Study. [PDF]

Mov Disord
Abstract Background Although clinical markers (eg, motor and cognitive impairment) in isolated rapid eye movement sleep behavior disorder (iRBD) are associated with faster phenoconversion, their longitudinal trajectory patterns (linear or nonlinear) remain unclear.
Zhou L, Liu Y, Huang B, Wang J, Tang S, Yang Y, Gong S, Chau SWH, Chan JWY, Yu MWM, Tsang JCC, Li SX, Lam SP, Mok VCT, Ma KKY, Chan AYY, Zhang J, Wing YK.   +17 more
europepmc   +2 more sources

Impact of CYP2C19 and CYP3A4 Inhibitor Use on Clopidogrel Clinical Effectiveness in CYP2C19 Genotyped Patients Undergoing Percutaneous Coronary Intervention. [PDF]

Clin Pharmacol Ther
CYP2C19 and CYP3A4 contribute to clopidogrel bioactivation. CYP2C19 no‐function alleles diminish clopidogrel's antiplatelet effects and clinical effectiveness. Coadministration of either a CYP2C19 or a CYP3A4 inhibitor may also reduce clopidogrel's antiplatelet effects and lead to phenoconversion in patients without a CYP2C19 no‐function allele (normal/
Shao D, Malavé JG, Rossi JS, Franchi F, Keeley EC, Angiolillo DJ, Stouffer GA, Cavallari LH, Lee CR.   +8 more
europepmc   +2 more sources

The Influence of Pharmacogenetics on the Clinical Relevance of Pharmacokinetic Drug–Drug Interactions: Drug–Gene, Drug–Gene–Gene and Drug–Drug–Gene Interactions

Pharmaceuticals, 2021
Drug interactions are a well-known cause of adverse drug events, and drug interaction databases can help the clinician to recognize and avoid such interactions and their adverse events. However, not every interaction leads to an adverse drug event.
Martina Hahn, Sibylle C. Roll
doaj   +1 more source

Personality profile and its association with conversion to neurodegenerative disorders in idiopathic REM sleep behavior disorder

npj Parkinson's Disease, 2022
Patients with Parkinson’s disease (PD) were described less extraverted and more neurotic. It remained unclear whether similar personality traits could be found in idiopathic rapid eye movement sleep behavior disorder (iRBD), a prodromal stage of PD, and ...
Li Zhou, Steven W. H. Chau, Yaping Liu, Jing Wang, Jihui Zhang, Ngan Yin Chan, Joey W. Y. Chan, Bei Huang, Sijing Chen, Shirley Xin Li, Vincent Chung Tong Mok, Yun Kwok Wing   +11 more
doaj   +1 more source

Decoding Prodromal Lewy Body Disease: Clinical Differences Between Isolated REM Sleep Behavior Disorder and Hyposmia With Dopamine Transporter Deficit. [PDF]

Eur J Neurol
Isolated REM sleep behavior disorder (iRBD) [n = 360] and hyposmia with dopamine transporter deficit [n = 1101] represent two enriched prodromal Lewy body disease cohorts. Using data from the Parkinson's Progression Markers Initiative, iRBD was associated with significantly greater autonomic symptom burden than hyposmia, driven by constipation and ...
Banerjee LV, Pasquini J, Henderson R, Pavese N, Anderson KN.   +4 more
europepmc   +2 more sources

Cholinergic dysfunction in isolated rapid eye movement sleep behaviour disorder links to impending phenoconversion [PDF]

\ua9 2024 The Author(s). European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.Background and purpose: Most patients with isolated rapid eye movement sleep behaviour disorder (iRBD) progress to a ...
Borghammer P, Tolosa E, Iranzo A, Moller M, Danielsen EH, Ostergaard K, Garrido A, Otto M, Vilas D, Moller A, Gaig C, Brooks DJ, Baun AM, Stokholm MG, Terkelsen MH, Johnsen EL, Santamaria J, Pavese N, Svendsen KB, Serradell M   +19 more
core   +7 more sources

Predictive risk factors of phenoconversion in idiopathic REM sleep behavior disorder: the Italian study “FARPRESTO” [PDF]

, 2022
Most patients with idiopathic REM sleep behavior disorder (iRBD) will develop an overt α-synucleinopathy over time, with a rate of phenoconversion of 73.5% after 12 years from diagnosis.
Figorilli M., Arnaldi D., Gigli G. L., d'Aloja E., Ferini-Strambi L., Maestri M., Antelmi Elena., and the FARPRESTO Consortium., Ferri R., Terzaghi M., Plazzi G., Antelmi E., Ingravallo F., Puligheddu M., Casaglia E.   +14 more
core   +3 more sources