Effect of CYP2C19 genotypes on tamoxifen metabolism and early-breast cancer relapse [PDF]
Scientific Reports, 2021 CYP2C19*2 and CYP2C19*17 might influence tamoxifen metabolism and clinical outcome. Our aim was to investigate the effect of CYP2C19 genotypes on tamoxifen concentrations and metabolic ratios (MRs) and breast cancer recurrence in a large cohort of ...
A. B. Sanchez-Spitman +5 more
doaj +2 more sources
Search for Novel Biomarkers to Predict Cytochrome P450 2C19 Activity Using Untargeted Metabolomics of Human Plasma [PDF]
MetabolitesBackground/Objectives: Cytochrome P450(CYP)2C19 activity varies widely among individuals. As genetic factors, CYP2C19*2 and CYP2C19*3 alleles reduce CYP2C19 activity, while the CYP2C19*17 allele increases CYP2C19 activity.
Ayako Oda +19 more
doaj +2 more sources
Frequencies of CYP2C19 Polymorphisms in Mexican Mestizo Patients with Coronary or Cerebral Atherosclerosis and Their Association with Residual Platelet Activity on Clopidogrel Treatment [PDF]
BiomedicinesBackground/Objectives: There is wide variability in the individual response to clopidogrel, which depends on CYP2C19 polymorphisms as well as on intrinsic and extrinsic platelet factors.
Raúl Izaguirre-Ávila +6 more
doaj +2 more sources
CYP2C19 c.681G>A Is not in Complete Linkage Disequilibrium With c.332‐23A>G: Implications for Pharmacogenetic Testing [PDF]
Clinical and Translational ScienceCYP2C19 plays an important role in the metabolism of many medications, including the antiplatelet agent clopidogrel, the antifungal agent voriconazole, selective serotonin reuptake inhibitors, select tricyclic antidepressants, and proton pump inhibitors.
Amy J. Turner +8 more
doaj +2 more sources
The impact of CYP2C19 genotype on phenoconversion by concomitant medication
Frontiers in Pharmacology, 2023 Introduction: Pharmacogenetics-informed drug prescribing is increasingly applied in clinical practice. Typically, drug metabolizing phenotypes are determined based on genetic test results, whereupon dosage or drugs are adjusted.
Laura M. de Jong +11 more
doaj +1 more source
Distribution of a novel CYP2C haplotype in Native American populations
Frontiers in Genetics, 2023 The CYP2C19 gene, located in the CYP2C cluster, encodes the major drug metabolism enzyme CYP2C19. This gene is highly polymorphic and no-function (CYP2C19*2 and CYP2C19*3), reduced function (CYP2C19*9) and increased function (CYP2C19*17) star alleles ...
Vanessa Câmara Fernandes +4 more
doaj +1 more source
Evaluation of changes in cytochrome P450 2C19 activity in type 2 diabetic rats before and after treatment, by using isolated perfused liver model [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): Alteration in drug metabolism is very likely in diabetes mellitus. This study assessed changes in CYP2C19 enzymatic activity in the liver using omeprazole as a probe in the animal model of type II diabetes (T2DM) before and after treatment ...
Navid Neyshaburinezhad +4 more
doaj +1 more source
Рациональная фармакотерапия в кардиологии, 2023 Aim. Study of the association of polymorphic variants of CYP2C19 (G681A), P2RY12 (H1/H2), ITGB3 (T1565C), ITGA2 (C807T), eNOS3 (T786C) genes with high residual platelet reactivity (HRPR) to clopidogrel and acetylsalicylic acid (ASA) at different terms of
T. P. Pronko +3 more
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Reviews in Cardiovascular Medicine, 2023 Percutaneous coronary intervention (PCI) is a widely used reperfusion strategy for coronary artery disease, with millions of procedures performed annually.
Junyan Zhang, Zhongxiu Chen, Yong He
doaj +1 more source
CYP2C19 Genetic Polymorphism in the East of Iran: Its Association with the Severity and Pattern of Coronary Artery Disease [PDF]
Journal of Cardio-Thoracic Medicine, 2019 Introduction: Since there has been a dearth of research on the assessment of CYP2C19 polymorphism in the east of Iran (Khorasan provinces), this study aimed to detect, CYP2C19*2 and CYP2C19*3 allele frequencies among patients with coronary artery disease.
Mahdi Zahedi +3 more
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