Results 31 to 40 of about 28,620 (235)

Dispensing of actionable pharmacogenetic drugs among adults receiving cardiovascular disease medications in the Northern Netherlands: A serial cross-sectional study. [PDF]

Clin Pharmacol Ther
The extent of pharmacogenetic (PGx) drug dispensing among Dutch adults receiving medications for cardiovascular disease (CVD) is unknown. Using the University of Groningen IADB.nl pharmacy database, we performed a serial cross‐sectional study (2019–2023) to estimate the annual prevalence of PGx drug dispensing and annual rates of initiation.
Zhang Z, Zhou G, Bos JHJ, Hak E, Feenstra T, Klont F.   +5 more
europepmc   +2 more sources

Urine metabolic ratio of omeprazole in relation to CYP2C19 polymorphisms in Russian peptic ulcer patients [PDF]

, 2017
Natalia P Denisenko,1–3 Dmitriy A Sychev,2 Zhanna M Sizova,3 Valeriy V Smirnov,4,5 Kristina A Ryzhikova,1 Zhannet A Sozaeva,1 Elena A Grishina1 1Research Center, Russian Medical Academy of Continuous Professional Education, Ministry of Healthcare ...
Valeriy Smirnov, Ryzhikova KA, Sychev DA, Sizova ZM, Dmitriy Sychev, Denisenko NP, Kristina Ryzhikova, Elena Grishina, Natalia Denisenko, Smirnov VV, Sozaeva ZA, Grishina EA, Zhanna Sizova, Zhannet Sozaeva   +13 more
core   +1 more source

Omeprazole‐induced acute interstitial nephritis is not related to CYP2C19 genotype or CYP2C19 phenotype [PDF]

British Journal of Clinical Pharmacology, 2010
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Omeprazole‐induced acute interstitial nephritis (OIAIN) is a rare adverse drug reaction. It is typically considered to be an idiosyncratic reaction affecting elderly patients. Omeprazole is a substrate for CYP2C19 and individuals who are homozygous variant for the null allele are poor metabolizers of this ...
Nuala A, Helsby, Wing-Yee, Lo, Ian J, Simpson, David M, Voss, Kaye E, Logan, Martin, Searle, John B W, Schollum, Janak R, de Zoysa   +7 more
openaire   +2 more sources

Association between CYP2C9 and CYP2C19 Polymorphism, Metabolism, and Neurotoxicity after Administration of Phenytoin: A Systematic Review

Keluwih, 2023
—Phenytoin is an antiepileptic drug (AED) metabolized by cytochrome P450 enzymes, especially by CYP2C9 (90%) and CYP2C19 (10%), where both enzymes are polymorphic so that they can undergo polymorphism and it can change the metabolic rate of the drug ...
Rizka Mardhiani, Yahdiana Harahap, Winnugroho Wiratman   +2 more
doaj   +1 more source

Patients with Chronic Inflammatory Diseases Can Experience Higher Exposure of Small Molecule Drugs than Healthy Volunteers: An Analysis of Recently Approved Drugs. [PDF]

Clin Pharmacol Ther
Chronic inflammation has long been known to downregulate the activity of certain cytochrome P450 (CYP) enzymes—the main enzymes responsible for the phase I metabolism of many small molecule drugs—potentially leading to higher exposures in patients with chronic inflammatory diseases compared to healthy volunteers. Neglecting this potential difference in
Tillil J, Gopalakrishnan S, Dong J, Venkatakrishnan K, Kloft C, Huisinga W, Klopp-Schulze L.   +6 more
europepmc   +2 more sources

Allelic frequency of PON1 Q192R, CYP2C19*2 and CYP2C19*17 among Jordanian patients taking clopidogrel [PDF]

, 2019
Purpose: To investigate the influence of allelic frequencies of PON1 Q192R, CYP2C19*2 and CYP2C19*17 genetic polymorphisms on the response to clopidogrel among Jordanian patients.Methods: Polymorphisms in CYP2C19 were assessed among 148 patients using ...
Rjoub, Malek, Saleh, Akram, Zihlif, Malek, Imraish, Amer, Hakooz, Nancy, Jarrar, Yazun   +5 more
core   +1 more source

Allele frequencies of single nucleotide polymorphisms of clinically important drug-metabolizing enzymes CYP2C9, CYP2C19, and CYP3A4 in a Thai population

Scientific Reports, 2021
Prior knowledge of allele frequencies of cytochrome P450 polymorphisms in a population is crucial for the revision and optimization of existing medication choices and doses.
Rattanaporn Sukprasong, Sumonrat Chuwongwattana, Napatrupron Koomdee, Thawinee Jantararoungtong, Santirhat Prommas, Pimonpan Jinda, Jiratha Rachanakul, Nutthan Nuntharadthanaphong, Nutcha Jongjitsook, Apichaya Puangpetch, Chonlaphat Sukasem   +10 more
doaj   +1 more source

CYP2C19 genotype and the PPIs – focus on rabeprazole [PDF]

Journal of Gastroenterology and Hepatology, 2005
Abstract: Amongst all the proton pump inhibitors (PPI), the hepatic metabolism of rabeprazole is least dependent on the CYP4502C19 system. Rabeprazole is therefore the PPI least affected by CYP4502C19 genetic polymorphism. This unique feature of rabeprazole complements rabeprazole's fast onset of action, and may lead to profound and consistent ...
Goh, KL, Wong, BCY, Lim, PWY
openaire   +3 more sources

The correlation of two different real-time PCR devices for the analysis of CYP2C19 pharmacogenetic results [PDF]

, 2023
CYP2C19 is a highly polymorphic gene responsible for the metabolism of commonly used drugs. CYP2C19*1, the wild-type allele, is associated with normal enzyme activity, whereas CYP2C19*2 and CYP2C19*17 lead to null and increased enzyme activity ...
González Andrade, Fabricio, Vicente Romero, Jorge, Fanlo Villacampa, Ana, Salgado Garrido, Josefa, Valiente Martín, Alberto, Alonso Llorente, Alba, Teijido Hermida, Óscar   +6 more
core   +3 more sources

The EMA Qualification Opinion for CYP Inhibition-Mediated Drug-Drug Interaction Predictions: Implications for PBPK Credibility Assessment in the Era of ICH M15. [PDF]

Clin Pharmacol Ther
Clinical pharmacology and pharmacometrics teams are now being encouraged to implement the ICH M15 framework in drug development to support model‐informed decisions in regulatory submissions. Although model performance is an important component of model evaluation, regulatory confidence also depends on the intended context of use (CoU) and the ...
Rowland Yeo K, Neuhoff S, Hatley O, Gardner I, Brochot C, Bois FY, Jamei M.   +6 more
europepmc   +2 more sources