Results 31 to 40 of about 27,792 (251)

Association between CYP2C19 genotype and the additional effect of cilostazol to clopidogrel resistance in neuroendovascular therapy [PDF]

, 2018
2018-05We investigated the association between CYP2C19 genotype and additional effect of cilostazol on clopidogrel resistance (CR) in neuroendovascular therapy.
Nishihori, Masahiro, Ito, Masashi, Kumakura, Yasuo, Furukawa-Hibi, Yoko, Araki, Yoshio, Shintai, Kazunori, Miyachi, Shigeru, Tajima, Hayato, Wakabayashi, Toshihiko, Imai, Tasuku, Izumi, Takashi, Yamada, Kiyofumi, Matsubara, Noriaki, Okamoto, Sho   +13 more
core   +1 more source

The Prevalence of Allele Frequencies of CYP2C19 Polymorphisms of Clinically Important Drug-Metabolizing Enzymes CYP2C19 in Moldova Healthy Population [PDF]

, 2023
Acces full text - https://doi.org/10.1007/978-3-031-42782-4_42Genetic polymorphisms of drug-metabolizing enzymes, such as cytochrome P450 oxidases, can alter the pharmacokinetic properties of administered drugs, leading to variability in drug responses ...
CUROCICHIN, Ghenadie, GALEA-ABDUSA, Daniela, CAPROS, Natalia, BUZA, Anastasia, DOGOT, Marta   +4 more
core   +1 more source

Allele frequencies of single nucleotide polymorphisms of clinically important drug-metabolizing enzymes CYP2C9, CYP2C19, and CYP3A4 in a Thai population

Scientific Reports, 2021
Prior knowledge of allele frequencies of cytochrome P450 polymorphisms in a population is crucial for the revision and optimization of existing medication choices and doses.
Rattanaporn Sukprasong, Sumonrat Chuwongwattana, Napatrupron Koomdee, Thawinee Jantararoungtong, Santirhat Prommas, Pimonpan Jinda, Jiratha Rachanakul, Nutthan Nuntharadthanaphong, Nutcha Jongjitsook, Apichaya Puangpetch, Chonlaphat Sukasem   +10 more
doaj   +1 more source

CYP2C19 genotype and the PPIs – focus on rabeprazole [PDF]

Journal of Gastroenterology and Hepatology, 2005
Abstract: Amongst all the proton pump inhibitors (PPI), the hepatic metabolism of rabeprazole is least dependent on the CYP4502C19 system. Rabeprazole is therefore the PPI least affected by CYP4502C19 genetic polymorphism. This unique feature of rabeprazole complements rabeprazole's fast onset of action, and may lead to profound and consistent ...
Goh, KL, Wong, BCY, Lim, PWY
openaire   +3 more sources

The Prevalence of CYP2C19 Polymorphism in Patients with Symptomatic Intracranial Atherosclerosis

Cerebrovascular Diseases Extra
Introduction: Clopidogrel and aspirin were proved to have benefit in symptomatic intracranial stenosis. CYP2C19 polymorphism (CYP2C19*1, CYP2C19*2, CYP2C19*3, and CYP2C19*17 alleles) affects efficacy of clopidogrel.
Songchai Kittipanprayoon, Pongpat Vorasayan, Aurauma Chutinet, Pajaree Chariyavilaskul, Nijasri C. Suwanwela   +4 more
doaj   +1 more source

Allelic frequency of PON1 Q192R, CYP2C19*2 and CYP2C19*17 among Jordanian patients taking clopidogrel [PDF]

, 2019
Purpose: To investigate the influence of allelic frequencies of PON1 Q192R, CYP2C19*2 and CYP2C19*17 genetic polymorphisms on the response to clopidogrel among Jordanian patients.Methods: Polymorphisms in CYP2C19 were assessed among 148 patients using ...
Rjoub, Malek, Saleh, Akram, Zihlif, Malek, Imraish, Amer, Hakooz, Nancy, Jarrar, Yazun   +5 more
core   +1 more source

Impact of the novel CYP2C:TG haplotype and CYP2B6 variants on sertraline exposure in a large patient population

Clinical and Translational Science, 2022
Sertraline is a commonly used SSRI antidepressant drug, metabolized by CYP2C19 and CYP2B6, that exhibits a substantial interindividual variation in clinical response, of which only a part can be attributed to known genetic variants.
Line Skute Bråten, Magnus Ingelman‐Sundberg, Marin M. Jukic, Espen Molden, Marianne Kristiansen Kringen   +4 more
doaj   +1 more source

CYP2C19 loss-of-function is associated with increased risk of hypertension in a Hakka population: a case-control study

BMC Cardiovascular Disorders, 2023
Background Genetic factors have a certain proportion in the risk factors of hypertension. The purpose was to investigate the relationship of cytochrome P450 2C19 (CYP2C19) polymorphisms with hypertension in Hakka population.
Nan Cai, Cunren Li, Xianfang Gu, Wenfeng Zeng, Jiawei Zhong, Jingfeng Liu, Guopeng Zeng, Junxing Zhu, Haifeng Hong   +8 more
doaj   +1 more source

Development of a Semi-Quantitative Assay to Detect Full-Length CYP2C19 RNA

BioTechniques, 2000
Cytochrome P450 2C19 (CYP2C19) is the enzyme responsible for the metabolism of a number of drugs, including anticonvulsants and antidepressants. We have developed a semi-quantitative competitive RTPCR assay to estimate the degree of expression of the ...
Xiao-Yan Wang, René H. Levy, Rodney J.Y. Ho   +2 more
doaj   +1 more source

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source