Results 1 to 10 of about 32,925 (256)
Frequency of CYP2D6*3 and *4 and metabolizer phenotypes in three mestizo Peruvian populations [PDF]
Pharmacia, 2021 Wild type genotypes (CYP2D6) and their allelic variants have been described in a sample of a Peruvian mestizo population. The global allele frequency was 0.015 for CYP2D6*3 and 0.051 for CYP2D6*4. The percentages of genotypes described were 97% CYP2D6*1/*
Angel T. Alvarado +10 more
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In vitro study on the effect of peucedanol on the activity of cytochrome P450 enzymes
Pharmaceutical Biology, 2021 Context Peucedanol is a major extract of Peucedanum japonicum Thunb. (Apiaceae) roots, which is a commonly used herb in paediatrics. Its interaction with cytochrome P450 enzymes (CYP450s) would lead to adverse effects or even failure of therapy ...
Cun Zhang +4 more
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Frontiers in Pharmacology, 2022 Aims: The CYP2D6*41 variant is the second or third frequent reduced function allele in Chinese with a frequency of around 3–4%, while it is the major reduced function allele in Indians, Saudi Arabians and Caucasians with frequencies of around 10–20%. The
Ye Jin +6 more
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CPT: Pharmacometrics & Systems Pharmacology, 2021 The cytochrome P450 (CYP) 2D6 enzyme exhibits large interindividual differences in metabolic activity. Patients are commonly assigned a CYP2D6 phenotype based on their CYP2D6 genotype, but there is a lack of consensus on how to translate genotypes into ...
Trine Frederiksen +4 more
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Does ethnicity impact CYP2D6 genotype–phenotype relationships?
Clinical and Translational Science, 2023 Polymorphism of the CYP2D6 gene leads to substantial interindividual variability in CYP2D6 enzyme activity. Despite improvements in prediction of CYP2D6 activity based on genotype information, large interindividual variability within CYP2D6 genotypes ...
Trine Frederiksen +4 more
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Development and validation of a next-generation sequencing panel for clinical pharmacogenetics [PDF]
Farmacia Hospitalaria, 2020 La rápida implantación clínica de las técnicas de secuenciación masiva en paralelo se debe a su capacidad para secuenciar un gran número de regiones genéticas con un coste menor a las técnicas convencionales.
Luis Ramudo-Cela +5 more
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Physicochemical and biopharmaceutical characterization of new sulfonamide derivatives of gallic acid
British Journal of Pharmacy, 2022 Gallic acid (GA) is known for its antioxidant activity which is restricted due to its low oral permeability. In this project the carboxylic group of (GA) was substituted with sulfonamide group and hydroxyl groups were methylated which resulted ...
Dania Hussein Alhyari +7 more
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Неотложная медицинская помощь, 2020 Relevance. One of the key components of the accelerated recovery protocols (ARP), in addition to minimizing the surgical approach, is an adequate postoperative analgesia.
A. A. Muradyan +7 more
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Frontiers in Pharmacology, 2023 CYP2D6 is one of the most polymorphic drug-metabolizing enzymes in the liver. While genetic CYP2D6 variants serve as clinical biomarkers to predict CYP2D6 activity, large inter-person variability in CYP2D6 expression remains unaccounted for.
Joseph M. Collins +3 more
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Neuropsychiatric Disease and Treatment, 2022 Yong-Hang Li,1,* Wei Huang,1,* Man-Yu Xiao,2 Shi-Qing Huang,1 Hui Chen,1 Zai-Fang Li,1 Xue-Song Li,1 Yong Cheng1,2 1The Third People’s Hospital of Foshan, Foshan, Guangdong, People’s Republic of China; 2Center on Translational Neuroscience ...
Li YH +7 more
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