A history and overview of phenotypic variability in CYP2D6 activity [PDF]
, 2014 CYP2D6 is a human cytochrome P450 that is responsible for the metabolism of a large number of drugs and chemicals. Interest in CYP2D6 has largely centered on the wide interindividual variability in its catalytic activity that stems from a common genetic ...
Idle, Jeffrey, Beyoglu, Diren
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Pharmacogenomics in Cancer Treatment: Challenges and Opportunities in African Settings. [PDF]
Cancer MedABSTRACT Background Cancer incidence in Africa is projected to reach 2.1 million new cases annually by 2040. Current treatment guidelines remain largely based on pharmacogenomic data predominantly from European and Asian genetic profiles, potentially compromising safety and efficacy in African patients.
Maphumulo NF, Rebello G, Ramsuran V.
europepmc +2 more sources
CYP2D6-polymorphism and effect of adjuvant tamoxifen in breast cancer patients
, 2023 Adjuvant tamoxifen at the standard dose of 20 mg daily for five to ten years reduces the risk for relapse and mortality in hormone sensitive breast cancer. The effect however varies and no early marker of poor response is yet available.
Linda Thorén (18661456)
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A novel simple method for determining CYP2D6 gene copy number and identifying allele(s) with duplication/multiplication. [PDF]
PLoS ONE, 2015 BACKGROUND:Cytochrome P450 2D6 (CYP2D6) gene duplication and multiplication can result in ultrarapid drug metabolism and therapeutic failure or excessive response in patients.
Taimour Langaee +4 more
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CYP2D6 genotyping in the daily routine of a psychiatric hospital – pharmacoeconomic evaluation
Фармакоэкономика, 2018 Today, pharmacogenetic tests are commonly used to improve the efficacy and safety of antipsychotic (AP) treatment. However, the economic aspects of their implementation in the psychiatry clinic routine are not well studied.Aim.To evaluate the ...
A. A. Kurylev +3 more
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Anemarsaponin BII inhibits the activity of CYP3A4, 2D6, and 2E1 with human liver microsomes
Pharmaceutical Biology, 2020 Context Anemarsaponin BII is one of the most active saponins isolated from Anemarrhena asphodeloides Bunge (Asparagaceae), a commonly used Chinese traditional paediatric medicine.
Mingwei Wang +4 more
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Rolapitant Is a Reversible Inhibitor of CYP2D6 [PDF]
Drug Metabolism and Disposition, 2019 Rolapitant [(Varubi), 5S,8S)-8-[[(1R)-1-[3,5 bis(trifluoromethyl phenyl]ethoxy]methyl]-8-phenyl-1,7-diazaspiro[4.5]decan-2-one] is a high-affinity NK1 receptor antagonist that was approved in September 2015 as a treatment for nausea and vomiting caused by chemotherapy.
Sarah M, Glass +5 more
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The CYP2D6 animal model: how to induce autoimmune hepatitis in mice [PDF]
, 2012 Autoimmune hepatitis is a rare but life threatening autoimmune disease of the liver of unknown etiology1,2. In the past many attempts have been made to generate an animal model that reflects the characteristics of the human disease 3-5.
Christen, Urs +2 more
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Tamoxifen and CYP2D6: A Contradiction of Data [PDF]
The Oncologist, 2012 Abstract Learning Objectives: After completing this course, the reader will be able to: Describe the significant heterogeneity among the published studies on the link between CYP2D6 genotype and tamoxifen treatment efficacy.Explain the role of CYP2D6 metabolism in the conversion of tamoxifen to its ...
Daniel L, Hertz +2 more
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Heterogeneity of the CYP2D6 gene among Malays in Malaysia [PDF]
, 2001 Background: Although Malays shared an origin with Chinese, their evolution saw substantial divergences. Phenotyping studies suggested that they differed in CYP2D6 polymorphism, with higher PM prevalence but lesser right-shift for debrisoquine MRs ...
Rahman, A.R.A. +5 more
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