Results 31 to 40 of about 44,894 (310)
Scientific Reports, 2021 Lysergic acid diethylamide (LSD) is a classic psychedelic substance that is used recreationally and investigated in psychiatric research. There are no pharmacogenetic studies on LSD.
P. Vizeli +5 more
semanticscholar +1 more source
CYP2D6 genotype and tamoxifen response for breast cancer: a systematic review and meta-analysis. [PDF]
, 2013 OBJECTIVE: To evaluate evidence on the association between CYP2D6 genotype and tamoxifen response through. DESIGN: Systematic review and meta-analysis of prospective, cross-sectional and case-control studies published to 2012.
Danny W. K. Lum +18 more
core +1 more source
Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection [PDF]
, 2008 Autoimmune liver diseases, such as autoimmune hepatitis (AIH) and primary biliary cirrhosis, often have severe consequences for the patient. Because of a lack of appropriate animal models, not much is known about their potential viral etiology. Infection
Hintereder, Gudrun +23 more
core +1 more source
Frontiers in Pharmacology, 2023 CYP2D6 is one of the most polymorphic drug-metabolizing enzymes in the liver. While genetic CYP2D6 variants serve as clinical biomarkers to predict CYP2D6 activity, large inter-person variability in CYP2D6 expression remains unaccounted for.
Joseph M. Collins +3 more
doaj +1 more source
Drug Metabolism and Pharmacokinetics, 2002 Novel single nucleotide polymorphisms (SNPs) were found in introns 1, 3, 4, 5, and 7 of the gene encoding cytochrome (CYP) 2D6 in 90 Japanese subjects. Some of these SNPs were associated with C2850T and/or C100T, which are key SNPs for CYP2D6(*)2 and CYP2D6(*)10, respectively.
SOYAMA, Akiko +6 more
openaire +2 more sources
The CYP2D6 animal model: how to induce autoimmune hepatitis in mice [PDF]
, 2012 Autoimmune hepatitis is a rare but life threatening autoimmune disease of the liver of unknown etiology1,2. In the past many attempts have been made to generate an animal model that reflects the characteristics of the human disease 3-5.
Christen, Urs +2 more
core +1 more source
Неотложная медицинская помощь, 2020 Relevance. One of the key components of the accelerated recovery protocols (ARP), in addition to minimizing the surgical approach, is an adequate postoperative analgesia.
A. A. Muradyan +7 more
doaj +1 more source
JAMA psychiatry, 2020 Importance Precise estimation of the drug metabolism capacity for individual patients is crucial for adequate dose personalization. Objective To quantify the difference in the antipsychotic and antidepressant exposure among patients with genetically ...
Filip Milosavljević +8 more
semanticscholar +1 more source
Медицинский совет, 2022 Introduction. Despite the huge number of modern recommendations for the treatment of patients with liver cirrhosis, there is still no clear scheme for prescribing non-selective beta-blockers.Aim. To evaluate effect of polymorphic markers CYP2D6*3, CYP2D6*
A. I. Parusov +6 more
doaj +1 more source
Impact of cytochrome P450 2D6 function on the chiral blood plasma pharmacokinetics of 3,4-methylenedioxymethamphetamine (MDMA) and its phase I and II metabolites in humans [PDF]
, 2016 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) metabolism is known to be stereoselective, with preference for S-stereoisomers. Its major metabolic step involves CYP2D6-catalyzed demethylenation to 3,4-dihydroxymethamphetamine (DHMA), followed by ...
Tingelhoff, Eva H. +26 more
core +1 more source