Results 31 to 40 of about 44,899 (264)

Akathisia Induced by Metoclopramide in a Pregnant Woman With Nausea and Vomiting: A Case Report. [PDF]

Neuropsychopharmacol Rep
This case report describes a patient who was hospitalized at 33 weeks of gestation and diagnosed with metoclopramide‐induced akathisia. Although the akathisia symptoms resolved 3 days after discontinuation of metoclopramide, a possible interaction with dextromethorphan, which the patient had been orally administering prior to hospitalization, cannot be
Nakamura R, Noto K, Shirata T, Saito Y, Takehara I, Nagase S, Suzuki A.   +6 more
europepmc   +2 more sources

Tailoring therapy for heart failure: the pharmacogenomics of adrenergic receptor signaling. [PDF]

, 2014
Heart failure is one of the leading causes of mortality in Western countries, and β-blockers are a cornerstone of its treatment. However, the response to these drugs is variable among individuals, which might be explained, at least in part, by genetic ...
Barrese, V, Femminella, GD, Ferrara, N, Rengo, G   +3 more
core   +2 more sources

PharmVar GeneFocus: CYP2D6 [PDF]

Clinical Pharmacology & Therapeutics, 2019
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human CYP2D6 gene locus. CYP2D6 genetic variation impacts the metabolism of numerous drugs and, thus, can impact drug efficacy and safety. This GeneFocus provides a comprehensive overview and summary of CYP2D6 genetic variation and describes how the ...
Charity Nofziger, Amy J. Turner, Katrin Sangkuhl, Michelle Whirl‐Carrillo, José A.G. Agúndez, John L. Black, Henry M. Dunnenberger, Gualberto Ruano, Martin A. Kennedy, Michael S. Phillips, Houda Hachad, Teri E. Klein, Andrea Gaedigk   +12 more
openaire   +2 more sources

CYP2D6 Phenotyping Using Urine, Plasma, and Saliva Metabolic Ratios to Assess the Impact of CYP2D6∗10 on Interindividual Variation in a Chinese Population

Frontiers in Pharmacology, 2017
Purpose: Asian populations have around 40–60% frequency of reduced function allele CYP2D6∗10 compared to 1–2% in Caucasian populations. The wide range of CYP2D6 enzyme activities in subjects with the CYP2D6∗10 variant is a big concern for clinical ...
Pei Hu, Rui Chen, Xin Zheng
doaj   +1 more source

Association of ABCB1, 5-HT3B receptor and CYP2D6 genetic polymorphisms with ondansetron and metoclopramide antiemetic response in Indonesian cancer patients treated with highly emetogenic chemotherapy. [PDF]

, 2011
Our study shows that in Indonesian cancer patients treated with highly cytostatic emetogenic, carriership of the CTG haplotype of the ABCB1 gene is related to an increased risk of delayed chemotherapy-induced nausea and ...
Baak-Pablo, Renee F, Gelderblom, Hans, Guchelaar, Henk-Jan, Hakimi, Mohammad, Mustofa, Mustofa, Nortier, Johann W R, Perwitasari, Dyah A, van der Straaten, Robert J H M, Wessels, Judith A M   +8 more
core   +2 more sources

Identification of novel CYP2D7-2D6 hybrids: non-functional and functional variants

Frontiers in Pharmacology, 2010
Polymorphic expression of CYP2D6 contributes to the wide range of activity observed for this clinically important drug metabolizing enzyme. In this report we describe novel CYP2D7/2D6 hybrid genes encoding non-functional and functional CYP2D6 protein and
Andrea Gaedigk, Lazara K M Jaime, Joseph S Bertino, Jr, Anick Bérard, Victoria Pratt, L D Bradford, J S Leeder   +6 more
doaj   +1 more source

A novel simple method for determining CYP2D6 gene copy number and identifying allele(s) with duplication/multiplication. [PDF]

PLoS ONE, 2015
BACKGROUND:Cytochrome P450 2D6 (CYP2D6) gene duplication and multiplication can result in ultrarapid drug metabolism and therapeutic failure or excessive response in patients.
Taimour Langaee, Issam Hamadeh, Arlene B Chapman, John G Gums, Julie A Johnson   +4 more
doaj   +1 more source

CYP2D6 genetic polymorphisms and phenotypes in different ethnicities of Malaysian breast cancer patients [PDF]

, 2016
The cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6) is an enzyme that is predominantly involved in the metabolism of tamoxifen. Genetic polymorphisms of the CYP2D6 gene may contribute to inter-individual variability in tamoxifen metabolism,
, Sharifah Noor Akmal, Abdul Rahman, Sabariah, Fee, Wai Chin, Rosli, Rozita, Soon, Choy Chan   +4 more
core   +1 more source

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

Angewandte Chemie, EarlyView.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +2 more sources

CYP2D6 genotyping in the daily routine of a psychiatric hospital – pharmacoeconomic evaluation

Фармакоэкономика, 2018
Today, pharmacogenetic tests are commonly used to improve the efficacy and safety of antipsychotic (AP) treatment. However, the economic aspects of their implementation in the psychiatry clinic routine are not well studied.Aim.To evaluate the ...
A. A. Kurylev, B. V. Andreev, A. S. Kolbin, O. V. Limankin   +3 more
doaj   +1 more source