Results 51 to 60 of about 44,894 (310)
A novel simple method for determining CYP2D6 gene copy number and identifying allele(s) with duplication/multiplication. [PDF]
PLoS ONE, 2015 BACKGROUND:Cytochrome P450 2D6 (CYP2D6) gene duplication and multiplication can result in ultrarapid drug metabolism and therapeutic failure or excessive response in patients.
Taimour Langaee +4 more
doaj +1 more source
Cyrius: accurate CYP2D6 genotyping using whole-genome sequencing data
The Pharmacogenomics Journal, 2020 Responsible for the metabolism of ~21% of clinically used drugs, CYP2D6 is a critical component of personalized medicine initiatives. Genotyping CYP2D6 is challenging due to sequence similarity with its pseudogene paralog CYP2D7 and a high number and ...
Xiao Chen +7 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2021 Genetic differences in cytochrome P450 (CYP)-mediated metabolism have been known for several decades. The clinically most important polymorphic CYP enzyme is CYP2D6, which plays a key role in the metabolism of many antidepressants and antipsychotics ...
E. Molden, M. Jukic
semanticscholar +1 more source
CYP2D6 genotyping in the daily routine of a psychiatric hospital – pharmacoeconomic evaluation
Фармакоэкономика, 2018 Today, pharmacogenetic tests are commonly used to improve the efficacy and safety of antipsychotic (AP) treatment. However, the economic aspects of their implementation in the psychiatry clinic routine are not well studied.Aim.To evaluate the ...
A. A. Kurylev +3 more
doaj +1 more source
Implikasi Klinis Variasi Jumlah Copy Gen CYP2D6 [PDF]
, 2023 Enzim CYP2D6 adalah salah satu varian sitokrom P450 (CYP450) yang berperan dalam metabolisme obat di hati. Isoform ini berperan dalam memetabolisme 25% obat yang saat ini beredar di pasaran. Aktivitas CYP450 dapat dipengaruhi oleh berbagai faktor seperti
Setiabudy, Rianto +2 more
core +1 more source
Anemarsaponin BII inhibits the activity of CYP3A4, 2D6, and 2E1 with human liver microsomes
Pharmaceutical Biology, 2020 Context Anemarsaponin BII is one of the most active saponins isolated from Anemarrhena asphodeloides Bunge (Asparagaceae), a commonly used Chinese traditional paediatric medicine.
Mingwei Wang +4 more
doaj +1 more source
Rolapitant Is a Reversible Inhibitor of CYP2D6 [PDF]
Drug Metabolism and Disposition, 2019 Rolapitant [(Varubi), 5S,8S)-8-[[(1R)-1-[3,5 bis(trifluoromethyl phenyl]ethoxy]methyl]-8-phenyl-1,7-diazaspiro[4.5]decan-2-one] is a high-affinity NK1 receptor antagonist that was approved in September 2015 as a treatment for nausea and vomiting caused by chemotherapy.
Sarah M, Glass +5 more
openaire +2 more sources
Tamoxifen and CYP2D6: A Contradiction of Data [PDF]
The Oncologist, 2012 Abstract Learning Objectives: After completing this course, the reader will be able to: Describe the significant heterogeneity among the published studies on the link between CYP2D6 genotype and tamoxifen treatment efficacy.Explain the role of CYP2D6 metabolism in the conversion of tamoxifen to its ...
Daniel L, Hertz +2 more
openaire +2 more sources
Clinical pharmacology and therapyBeta‐blockers are widely used medications for a variety of indications, including heart failure, myocardial infarction, cardiac arrhythmias, and hypertension.
J. Duarte +17 more
semanticscholar +1 more source
Identification of new alleles and the determination of alleles and genotypes frequencies at the CYP2D6 gene in Emiratis. [PDF]
PLoS ONE, 2011 CYP2D6 belongs to the cytochrome P450 superfamily of enzymes and plays an important role in the metabolism of 20-25% of clinically used drugs including antidepressants.
Rula Y Qumsieh +5 more
doaj +1 more source