Results 61 to 70 of about 44,894 (310)

Transcriptional Regulation of CYP2D6 Expression [PDF]

Drug Metabolism and Disposition, 2017
CYP2D6-mediated drug metabolism exhibits large interindividual variability. Although genetic variations in the CYP2D6 gene are well known contributors to the variability, the sources of CYP2D6 variability in individuals of the same genotype remain unexplained.
Xian, Pan, Miaoran, Ning, Hyunyoung, Jeong   +2 more
openaire   +2 more sources

Dispensing of actionable pharmacogenetic drugs among adults receiving cardiovascular disease medications in the Northern Netherlands: A serial cross-sectional study. [PDF]

Clin Pharmacol Ther
The extent of pharmacogenetic (PGx) drug dispensing among Dutch adults receiving medications for cardiovascular disease (CVD) is unknown. Using the University of Groningen IADB.nl pharmacy database, we performed a serial cross‐sectional study (2019–2023) to estimate the annual prevalence of PGx drug dispensing and annual rates of initiation.
Zhang Z, Zhou G, Bos JHJ, Hak E, Feenstra T, Klont F.   +5 more
europepmc   +2 more sources

CYP2D6 genotype dependent oxycodone metabolism in postoperative patients. [PDF]

, 2013
BACKGROUND: The impact of polymorphic cytochrome P450 CYP2D6 enzyme on oxycodone's metabolism and clinical efficacy is currently being discussed. However, there are only spare data from postoperative settings.
Musshoff, Frank, Malte Book, Zhang, Lan, Frank Musshoff, Lan Zhang, Ulrike M Stamer, Lehmann, Lutz E., Book, Malte, Stuber, Frank, Lutz E Lehmann, Frank Stuber, Stamer, Ulrike M.   +11 more
core   +3 more sources

ผลของภาวะพหุสัณฐานของยีน CYP2D6 ต่อเภสัชจลนศาสตร์ของยาทาม็อกซิเฟนในผู้ป่วยไทยโรคมะเร็งเต้านม [PDF]

, 2011
Thesis (M.Sc.)--Chulalongkorn University, 2011The purposes of this study were to explore CYP2D6*10 allele frequency in Thai breast cancer patients and compare tamoxifen and its metabolites plasma concentration between patients with CYP2D6*1 and CYP2D6*10
Pichayapa Rungwanonchai
core   +1 more source

Application of Physiologically Based Pharmacokinetic Modeling to Optimize Assessment of Age-Related Fluoxetine Accumulation in the Elderly. [PDF]

CPT Pharmacometrics Syst Pharmacol
ABSTRACT This study quantified age‐related differences in fluoxetine pharmacokinetics and evaluated the influence of CYP2D6 phenotype using physiologically based pharmacokinetic (PBPK) modeling integrated with clinical therapeutic drug monitoring data.
Jang YJ, Heo DG, Hong E.
europepmc   +2 more sources

Resolving CYP2D6 Structural Complexity with Long-Read Sequencing: Implications for Tamoxifen Precision Dosing in Thai Breast Cancer Patients. [PDF]

Clin Pharmacol Ther
Cytochrome P450 2D6 (CYP2D6)‐mediated bioactivation of tamoxifen to endoxifen is a key determinant of therapeutic efficacy in estrogen receptor‐positive breast cancer. In Asian populations, the high prevalence of structurally complex CYP2D6 alleles complicates conventional genotyping, limiting accurate genotype–phenotype correlation.
Boonyuen U, Talukam S, Jacob BAC, Matphong W, Chamchoy K, Reamtong O, Meesiripan N, Yamagishi J, Phanchana M, Rattadilok C.   +9 more
europepmc   +2 more sources

Real‐World Longitudinal Data on the Impact of Hydroxychloroquine Blood Level Monitoring on Lupus Outcomes: Results of a Prospective Longitudinal Cohort Study

Arthritis Care &Research, EarlyView.
Objective Hydroxychloroquine (HCQ) is a cornerstone therapy in systemic lupus erythematosus (SLE), but the weight‐based dosing does not account for clinical factors that can introduce individual variability in drug metabolism and clearance. We leveraged longitudinal data from a prospective SLE cohort to identify clinical factors that predict ...
Jay J. Patel, Fauzia Hollangel, Caroline Packee, Amita Kapoor, Brad Rovin, Nathalie Costedoat‐Chalumeau, Shivani Garg   +6 more
wiley   +1 more source

Identification of novel CYP2D7-2D6 hybrids: non-functional and functional variants

Frontiers in Pharmacology, 2010
Polymorphic expression of CYP2D6 contributes to the wide range of activity observed for this clinically important drug metabolizing enzyme. In this report we describe novel CYP2D7/2D6 hybrid genes encoding non-functional and functional CYP2D6 protein and
Andrea Gaedigk, Lazara K M Jaime, Joseph S Bertino, Jr, Anick Bérard, Victoria Pratt, L D Bradford, J S Leeder   +6 more
doaj   +1 more source

Optimized Ex Vivo Human Liver Slice Culture Maintains Extended Viability and Function for Hepatotoxicity Testing

Advanced Science, EarlyView.
An optimized ex vivo human liver slice culture system preserves tissue architecture, hepatocyte function, and immune‐stromal complexity for at least five days. By refining slice thickness, oxygenation, air‐liquid interface, and extracellular matrix support, the platform enables human‐relevant hepatotoxicity testing and mechanistic studies, offering a ...
Huiche Feng, Cinzia Esposito, Andrej Benjak, Matthias S. Matter, Miriam Cieri, Camilla De Carlo, Philipp Sedlaczek, Fabian Haak, Mattia Marinucci, Gabriel Fridolin Hess, Otto Kollmar, Mairene Coto‐Llerena, Luca Di Tommaso, Visar Vela, Lukas Bubendorf, Luigi M. Terracciano, Charlotte K. Y. Ng, Salvatore Piscuoglio   +17 more
wiley   +1 more source

Potential role of CYP2D6 in the central nervous system [PDF]

, 2013
1. Cytochrome P450 2D6 (CYP2D6) is a pivotal enzyme responsible for a major drug oxidation polymorphism in human populations. Distribution of CYP2D6 in brain and its role in serotonin metabolism suggest that CYP2D6 may have a function in the central ...
Zhen, Yueying, Yu, Aiming, Gonzalez, Frank J, Cheng, Jie, Krausz, Kristopher W., Gonzalez, Frank J., Krausz, Kristopher W, Idle, Jeffrey R., Tyndale, Rachel F., Beyoglu, Diren, Tyndale, Rachel F, Idle, Jeffrey R, Miksys, Sharon   +12 more
core   +1 more source