Results 11 to 20 of about 44,894 (310)
Rapid Detection of the CYP2D6*3, CYP2D6*4, and CYP2D6*6 Alleles by Tetra-Primer PCR and of the CYP2D6*5 Allele by Multiplex Long PCR [PDF]
Clinical Chemistry, 2000 Abstract Background: Interindividual differences in CYP2D6 activity range from total absence of metabolism of certain drugs to ultrafast metabolism and can produce adverse effects or lack of therapeutic effect under standard therapy. Several mutations have been described in the CYP2D6 gene that abolish CYP2D6 activity.
Hersberger, Martin +3 more
openaire +4 more sources
Assessment of Activity Levels for CYP2D6*1, CYP2D6*2, and CYP2D6*41 Genes by Population Pharmacokinetics of Dextromethorphan [PDF]
Clinical Pharmacology & Therapeutics, 2010 The pharmacokinetics of dextromethorphan (DM) is markedly influenced by cytochrome P450 2D6 (CYP2D6) enzyme polymorphisms. The aim of this study was to quantify the effects of the CYP2D6*1, *2, and *41 variants on DM metabolism in vivo and to identify other sources of pharmacokinetic variability.
Abduljalil, K +8 more
openaire +5 more sources
Egyptian Journal of Medical Human Genetics, 2017 Cytochromes are proteins that catalyze electron transfer reactions of many metabolic pathways. They are involved in drug metabolism and thus determines the therapeutic safety and efficacy of drugs in patients. Cytochrome P450 in mitochondria accounts for 90% of the oxidative metabolism of clinically used drugs during phase 1 reaction. CYP2D6 is a major
Gopisankar, Mohanan Geetha +1 more
openaire +4 more sources
Exploratory Evaluation of Solanidine as an Endogenous Marker for CYP2D6‐Mediated Drug–Drug–Gene Interactions of Venlafaxine in Koreans [PDF]
Clinical and Translational ScienceCYP2D6‐mediated drug–drug–gene interactions (DDGIs) are known to influence the pharmacokinetics of venlafaxine and its metabolism to O‐desmethylvenlafaxine.
Sungyeun Bae +8 more
doaj +2 more sources
PharmVar Tutorial on CYP2D6 Structural Variation Testing and Recommendations on Reporting
Clinical pharmacology and therapy, 2023 The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human CYP2D6 gene locus and a comprehensive summary of structural variation.
Amy J Turner +16 more
semanticscholar +1 more source
In vitro study on the effect of peucedanol on the activity of cytochrome P450 enzymes
Pharmaceutical Biology, 2021 Context Peucedanol is a major extract of Peucedanum japonicum Thunb. (Apiaceae) roots, which is a commonly used herb in paediatrics. Its interaction with cytochrome P450 enzymes (CYP450s) would lead to adverse effects or even failure of therapy ...
Cun Zhang +4 more
doaj +1 more source
Metoclopramide is metabolized by CYP2D6 and is a reversible inhibitor, but not inactivator, of CYP2D6 [PDF]
Xenobiotica, 2013 1. Metoclopramide is a widely used clinical drug in a variety of medical settings with rare acute dystonic events reported. The aim of this study was to assess a previous report of inactivation of CYP2D6 by metoclopramide, to determine the contribution of various CYPs to metoclopramide metabolism, and to identify the mono-oxygenated products of ...
Mara R, Livezey +5 more
openaire +2 more sources
Frontiers in Pharmacology, 2022 Aims: The CYP2D6*41 variant is the second or third frequent reduced function allele in Chinese with a frequency of around 3–4%, while it is the major reduced function allele in Indians, Saudi Arabians and Caucasians with frequencies of around 10–20%. The
Ye Jin +6 more
doaj +1 more source
Meta-analysis of probability estimates of worldwide variation of CYP2D6 and CYP2C19
Translational Psychiatry, 2021 Extensive migration has led to the necessity of knowledge regarding the treatment of migrants with different ethnical backgrounds. This is especially relevant for pharmacological treatment, because of the significant variation between migrant groups in ...
A. Koopmans +4 more
semanticscholar +1 more source
CPT: Pharmacometrics & Systems Pharmacology, 2021 The cytochrome P450 (CYP) 2D6 enzyme exhibits large interindividual differences in metabolic activity. Patients are commonly assigned a CYP2D6 phenotype based on their CYP2D6 genotype, but there is a lack of consensus on how to translate genotypes into ...
Trine Frederiksen +4 more
doaj +1 more source