Results 21 to 30 of about 44,894 (310)
Does ethnicity impact CYP2D6 genotype–phenotype relationships?
Clinical and Translational Science, 2023 Polymorphism of the CYP2D6 gene leads to substantial interindividual variability in CYP2D6 enzyme activity. Despite improvements in prediction of CYP2D6 activity based on genotype information, large interindividual variability within CYP2D6 genotypes ...
Trine Frederiksen +4 more
doaj +1 more source
Development and validation of a next-generation sequencing panel for clinical pharmacogenetics [PDF]
Farmacia Hospitalaria, 2020 La rápida implantación clínica de las técnicas de secuenciación masiva en paralelo se debe a su capacidad para secuenciar un gran número de regiones genéticas con un coste menor a las técnicas convencionales.
Luis Ramudo-Cela +5 more
doaj +1 more source
How to Integrate CYP2D6 Phenoconversion into Clinical Pharmacogenetics: A Tutorial
Clinical pharmacology and therapy, 2021 CYP2D6 genotype is increasingly being integrated into practice to guide prescribing of certain medications. The CYP2D6 drug metabolizing enzyme is susceptible to inhibition by concomitant drugs, which can lead to a clinical phenotype that is different ...
Emily J. Cicali +9 more
semanticscholar +1 more source
Characterisation of CYP2D6 pharmacogenetic variation in sub-Saharan African populations
Clinical pharmacology and therapy, 2022 Cytochrome P450 2D6 (CYP2D6) is a key enzyme in drug response owing to its involvement in the metabolism of ~ 25% of clinically prescribed medications. The encoding CYP2D6 gene is highly polymorphic, and many pharmacogenetics studies have been performed ...
David Twesigomwe +13 more
semanticscholar +1 more source
Is CYP2D6 phenotype predictable from CYP2D6 genotype? [PDF]
Microchemical Journal, 2018 Abstract Genetic polymorphism of cytochrome P450s results in clinically significant modifications in patients' drug metabolizing capacities. CYP2D6 has a crucial role in the elimination of several clinically important drugs (antiarrhythmics, beta-adrenergic blockers, psychopharmacons and analgesics); however, the prediction of the phenotypic ...
Ádám Ferenc Kiss +6 more
openaire +2 more sources
Assessing the Mechanism of Fluoxetine-Mediated CYP2D6 Inhibition
Pharmaceutics, 2021 Fluoxetine is still one of the most widely used antidepressants in the world. The drug is extensively metabolized by several cytochrome P450 (CYP450) enzymes and subjected to a myriad of CYP450-mediated drug interactions.
M. Deodhar +4 more
semanticscholar +1 more source
A history and overview of phenotypic variability in CYP2D6 activity [PDF]
, 2014 CYP2D6 is a human cytochrome P450 that is responsible for the metabolism of a large number of drugs and chemicals. Interest in CYP2D6 has largely centered on the wide interindividual variability in its catalytic activity that stems from a common genetic ...
Idle, Jeffrey, Beyoglu, Diren
core +2 more sources
Frequencies of CYP2D6 genetic polymorphisms in Arab populations
Human Genomics, 2022 CYP2D6 is a key drug-metabolizing enzyme implicated in the biotransformation of approximately 25% of currently prescribed drugs. Interindividual and interethnic differences in CYP2D6 enzymatic activity, and hence variability in substrate drug efficacy ...
Mousa Alali +5 more
semanticscholar +1 more source
Tamoxifen and CYP2D6: A Controversy in Pharmacogenetics [PDF]
, 2018 Tamoxifen reduces the rate of breast cancer recurrence by about one-half. It is converted to more active metabolites by enzymes encoded by polymorphic genes, including cytochrome P450 2D6 (CYP2D6) and transported by ATP-binding cassette transporters. Genetic polymorphisms that confer reduced CYP2D6 activity or concurrent use of CYP2D6-inhibiting drugs ...
Cronin-Fenton, Deirdre P, Damkier, Per
openaire +4 more sources
Physicochemical and biopharmaceutical characterization of new sulfonamide derivatives of gallic acid
British Journal of Pharmacy, 2022 Gallic acid (GA) is known for its antioxidant activity which is restricted due to its low oral permeability. In this project the carboxylic group of (GA) was substituted with sulfonamide group and hydroxyl groups were methylated which resulted ...
Dania Hussein Alhyari +7 more
doaj +1 more source