Терапевтический архив, 2022 Aim. To study the polymorphic markers CYP2D6*4 (G1846A, rs3892097), CYP2D6*6 (T1707del, rs5030655), CYP2D6*10 (C100T, rs1065852), CYP2D6*41 (G2988A, rs28371725) and CYP2D6*3 (A2549del, rs4986774) role in treatment optimization of portal hypertension with
Dmitry A. Sychev +7 more
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PharmVar GeneFocus: CYP2D6 [PDF]
Clinical Pharmacology & Therapeutics, 2019 The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human CYP2D6 gene locus. CYP2D6 genetic variation impacts the metabolism of numerous drugs and, thus, can impact drug efficacy and safety. This GeneFocus provides a comprehensive overview and summary of CYP2D6 genetic variation and describes how the ...
Charity Nofziger +12 more
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Identification of novel CYP2D7-2D6 hybrids: non-functional and functional variants
Frontiers in Pharmacology, 2010 Polymorphic expression of CYP2D6 contributes to the wide range of activity observed for this clinically important drug metabolizing enzyme. In this report we describe novel CYP2D7/2D6 hybrid genes encoding non-functional and functional CYP2D6 protein and
Andrea Gaedigk +6 more
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A novel simple method for determining CYP2D6 gene copy number and identifying allele(s) with duplication/multiplication. [PDF]
PLoS ONE, 2015 BACKGROUND:Cytochrome P450 2D6 (CYP2D6) gene duplication and multiplication can result in ultrarapid drug metabolism and therapeutic failure or excessive response in patients.
Taimour Langaee +4 more
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CYP2D6 genotyping in the daily routine of a psychiatric hospital – pharmacoeconomic evaluation
Фармакоэкономика, 2018 Today, pharmacogenetic tests are commonly used to improve the efficacy and safety of antipsychotic (AP) treatment. However, the economic aspects of their implementation in the psychiatry clinic routine are not well studied.Aim.To evaluate the ...
A. A. Kurylev +3 more
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Anemarsaponin BII inhibits the activity of CYP3A4, 2D6, and 2E1 with human liver microsomes
Pharmaceutical Biology, 2020 Context Anemarsaponin BII is one of the most active saponins isolated from Anemarrhena asphodeloides Bunge (Asparagaceae), a commonly used Chinese traditional paediatric medicine.
Mingwei Wang +4 more
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Sex Differences in Associations Between CYP2D6 Phenotypes and Response to Opioid Analgesics
Pharmacogenomics and Personalized Medicine, 2020 Guilherme S Lopes,1,2 Suzette J Bielinski,2 Ann M Moyer,3 John Logan Black III,3 Debra J Jacobson,1 Ruoxiang Jiang,1 Nicholas B Larson,1 Jennifer L St Sauver2 1Division of Biomedical Statistics and Informatics, Department of Health Sciences Research ...
Lopes GS +7 more
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Identification of new alleles and the determination of alleles and genotypes frequencies at the CYP2D6 gene in Emiratis. [PDF]
PLoS ONE, 2011 CYP2D6 belongs to the cytochrome P450 superfamily of enzymes and plays an important role in the metabolism of 20-25% of clinically used drugs including antidepressants.
Rula Y Qumsieh +5 more
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Transcriptional Regulation of CYP2D6 Expression [PDF]
Drug Metabolism and Disposition, 2017 CYP2D6-mediated drug metabolism exhibits large interindividual variability. Although genetic variations in the CYP2D6 gene are well known contributors to the variability, the sources of CYP2D6 variability in individuals of the same genotype remain unexplained.
Xian, Pan +2 more
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Transgenic HepaRG cells expressing CYP2D6 as an improved model of primary human hepatocytes
Pharmacology Research & Perspectives, 2022 CYP2D6 and CYP3A4, which are members of the cytochrome P450 superfamily of metabolic enzymes, play major roles in the metabolism of commonly available drugs.
Shota Okuyama +5 more
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