Results 41 to 50 of about 2,663 (168)
Sleep Disturbances and Phenoconversion in Patients with REM Sleep Behavior Disorder [PDF]
Journal of Clinical Medicine, 2021 Objective: We aimed to investigate relationships between sleep disturbances and phenoconversion to neurodegenerative diseases in patients with REM sleep behavior disorder (RBD). Method: Using a comprehensive sleep database in a university-affiliated hospital between December 2014 and March 2021, we reviewed the data of 226 patients with RBD (182 ...
Hyunjin Jo +4 more
openaire +2 more sources
Phenoconversion of CYP2D6 by inhibitors modifies aripiprazole exposure [PDF]
European Archives of Psychiatry and Clinical Neuroscience, 2019 The efficacy of aripiprazole therapy and the risk of adverse reactions are influenced by substantial inter-individual variability in aripiprazole metabolizing capacity. In vitro studies assigned the potential role in aripiprazole metabolism to CYP2D6 and CYP3A enzymes; therefore, the association between the steady-state aripiprazole plasma ...
Ádám Kiss +9 more
openaire +3 more sources
, 2021 Introduction: Polypharmacy and genetic variants that strongly influence medication response (pharmacogenomics, PGx) are two well-described risk factors for adverse drug reactions.
Carl M. J. Kirkpatrick (11294292) +4 more
core +1 more source
CYP450 Genotype—Phenotype Concordance Using the Geneva Micrococktail in a Clinical Setting
Frontiers in Pharmacology, 2021 Pharmacokinetic variability is a major source of differences in drug response and can be due to genetic variants and/or drug-drug interactions. Cytochromes P450 are among the most studied enzymes from a pharmacokinetic point of view.
Kuntheavy Ing Lorenzini +6 more
doaj +1 more source
Medicina, 2023 Pharmacotherapy for major depressive disorder (MDD) typically consists of trial-and-error and clinician preference approaches, where patients often fail one or more antidepressants before finding an optimal regimen.
Joshua Russell +6 more
doaj +1 more source
Cardiosomal microRNAs Are Essential in Post-Infarction Myofibroblast Phenoconversion [PDF]
International Journal of Molecular Sciences, 2019 The inclusion of microRNAs (miRNAs) in extracellular microvesicles/exosomes (named cardiosomes when deriving from cardiomyocytes) allows their active transportation and ensures cell-cell communication. We hypothesize that cardiosomal miRNAs play a pivotal role in the activation of myofibroblasts following ischemic injury.
Morelli Marco Bruno +4 more
openaire +5 more sources
Characterization of Depressive and Anxiety Symptoms in Idiopathic REM Sleep Behavior Disorder
Journal of Parkinson’s Disease, 2021 Background: Depression and anxiety are common in synucleinopathies and often present during prodromal stages, including idiopathic/isolated REM sleep behavior disorder (iRBD).
Lucy Honeycutt +5 more
doaj +1 more source
Phenoconversion: Drug-Drug-Gene Interactions [PDF]
, 2019 Based on the extensive, poor, intermediate and ultrarapid phenotypes of patients, inferences may be made relative to drug metabolism, ultimately leading to changes in therapeutic drug choice or dosing.
Kulp, Molly +4 more
core +1 more source
Evaluation of changes in cytochrome P450 2C19 activity in type 2 diabetic rats before and after treatment, by using isolated perfused liver model [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): Alteration in drug metabolism is very likely in diabetes mellitus. This study assessed changes in CYP2C19 enzymatic activity in the liver using omeprazole as a probe in the animal model of type II diabetes (T2DM) before and after treatment ...
Navid Neyshaburinezhad +4 more
doaj +1 more source
Dasatinib-induced nephrotic syndrome: a case of phenoconversion?
Croatian Medical Journal, 2019 We present the case of a 33-year-old chronic myeloid leukemia (CML) female patient, in whom the occurrence of nephrotic syndrome, during the treatment with tyrosine kinase activity inhibitors (TKIs), was potentially influenced by transient phenoconversion.
Mandac Rogulj, Inga +6 more
openaire +6 more sources