Results 41 to 50 of about 3,015 (189)

Multi-site investigation of strategies for the clinical implementation of CYP2D6 genotyping to guide drug prescribing [PDF]

, 2019
PURPOSE: A number of institutions have clinically implemented CYP2D6 genotyping to guide drug prescribing. We compared implementation strategies of early adopters of CYP2D6 testing, barriers faced by both early adopters and institutions in the process
Beitelshees, Amber L., Bell, Gillian C., Bishop, Jeffrey R., Blake, Kathryn, Cavallari, Larisa H., Crona, Daniel J., Dressler, Lynn, Duong, Benjamin Q., Empey, Philip E., Gregg, Ryan A., Hicks, J. Kevin, Hines, Lindsay J., Johnson, Julie A., Lee, James C., Limdi, Nita A., Obeng, Aniwaa Owusu, Peterson, Josh F., Pratt, Victoria M., Prows, Cynthia A., Ramsey, Laura B., Scott, Stuart A., Shelton, Richard C., Skaar, Todd C., Smith, D. Max, Tuteja, Sony, Van Driest, Sara L., Weitzel, Kristin Wiisanen   +26 more
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Phenoconversion from probable rapid eye movement sleep behavior disorder to mild cognitive impairment to dementia in a population-based sample [PDF]

, 2017
© 2017 The Authors Introduction Rapid eye movement sleep behavior disorder (RBD) is strongly associated with synucleinopathies. In 2012, we reported an increased risk of mild cognitive impairment (MCI) and Parkinson disease (PD) in cognitively normal ...
Boeve, Bradley F, Boot, Brendon P, Christianson, Teresa J.H., Ferman, Tanis J, Geda, Yonas E, Jung, Youngsin, Knopman, David S, McDade, Eric, Mielke, Michelle M, Petersen, Ronald C, Silber, Michael H, St Louis, Erik K   +11 more
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Increased Transferrin Sialylation Predicts Phenoconversion in Isolated REM Sleep Behavior Disorder [PDF]

Movement Disorders, 2022
AbstractBackgroundSialic acid–protein interactions are involved in regulating central nervous system immunity; therefore, derangements in sialylation could be involved in neurodegeneration.ObjectivesWe evaluate the differences in serum transferrin sialylation in prodromal and early‐stage Parkinson's disease (PD), its relation to substantia nigra ...
Ranjani Ganapathy S., Kateřina Levová, Lenka Kotačková, Jiří Trnka, David Zogala, Jan Rusz, Tomáš Zima, David Devos, Karel Šonka, Evžen Růžička, Marta Kalousová, Petr Dušek   +11 more
openaire   +2 more sources

Neuronal human BACE1 knock-in induces systemic diabetes in mice [PDF]

, 2016
Acknowledgements The authors thank S. Tammireddy (Diabetes and Cardiovascular Science, University of the Highlands and Islands, Inverness, UK) for technical support with the lipidomics component. Funding We would like to thank R.
Dekeryte, Ruta, Delibegovic, Mirela, Doherty, Mary K., Koss, David, Mingarelli, Marco, Mody, Nimesh, Platt, Bettina, Pluci??ska, Kaja, Riedel, Gernot, Shearer, Kirsty, Welch, Andy, Whitfield, Phillip, Whitfield, Phillip D.   +12 more
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Sleep Disturbances and Phenoconversion in Patients with REM Sleep Behavior Disorder [PDF]

Journal of Clinical Medicine, 2021
Objective: We aimed to investigate relationships between sleep disturbances and phenoconversion to neurodegenerative diseases in patients with REM sleep behavior disorder (RBD). Method: Using a comprehensive sleep database in a university-affiliated hospital between December 2014 and March 2021, we reviewed the data of 226 patients with RBD (182 ...
Hyunjin Jo, Dongyeop Kim, Jooyeon Song, Sujung Choi, Eunyeon Joo   +4 more
openaire   +2 more sources

Obesity‐induced diabetes and lower urinary tract fibrosis promote urinary voiding dysfunction in a mouse model [PDF]

, 2013
BACKGROUND Progressive aging‐ and inflammation‐associated fibrosis effectively remodels the extracellular matrix (ECM) to increase prostate tissue stiffness and reduce urethral flexibility, resulting in urinary flow obstruction and lower urinary tract ...
Adler, Begley, Begley, Begley, Begley, Delongchamps, Dib, Garber, Gharaee-Kermani, Guess, Harwood, Hodges, Joseph, Khoo, Klein, Koskimaki, Kramer, Lecka-Czernik, Lumeng, Ma, Macoska, McVary, Meigs, Michel, Nickel, Niimi, Pahl, Parsons, Parsons, Robert, Sarma, Schauer, Schauer, Scotton, Shoelson, Spencer, Steiner, Sugimura, Takeda, Takeda, Taube, Theyer, Tuxhorn, Verhamme, Wynn   +44 more
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Mild motor impairment as prodromal state in amyotrophic lateral sclerosis:A new diagnostic entity [PDF]

, 2022
Amyotrophic lateral sclerosis, when viewed as a biological entity rather than a clinical syndrome, probably evolves along a continuum, with the initial clinically silent phase eventually evolving into clinically manifest amyotrophic lateral sclerosis ...
Andersen, Peter M, Benatar, Michael, Cosentino, Stephanie, Granit, Volkan, Grignon, Anne-Laure, Malaspina, Andrea, McHutchison, Caroline, Wuu, Joanne   +7 more
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Idiopathic rapid eye movement sleep behaviour disorder: a potential gateway to the development of disease-modifying treatments in neurodegenerative disorders [PDF]

, 2016
Idiopathic rapid eye movement (REM) sleep behavioural disorder (RBD) is classified as one of the REM parasomnias with clinical characteristics including unpleasant dreams, acting out of dreams, and loss of the typical muscle atonia during the REM phase ...
Peall, Kathryn J., Robertson, Neil
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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors [PDF]

, 2015
Selective serotonin reuptake inhibitors (SSRIs) are primary treatment options for major depressive and anxiety disorders. CYP2D6 and CYP2C19 polymorphisms can influence the metabolism of SSRIs, thereby affecting drug efficacy and safety.
Bishop, Jeffrey R., Caudle, Kelly E., Chiulli, Dana L., Gaedigk, Andrea, Graham, Rebecca L., Hicks, J. Kevin, Ji, Yuan, Klein, Teri E., Leckband, Susan G., Leeder, J. Steven, LLerena, Adrián, Müller, Daniel J, Sangkuhl, Katrin, Scott, Stuart A., Skaar, Todd C., Stingl, Julia C.   +15 more
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From metabonomics to pharmacometabonomics: The role of metabolic profiling in personalized medicine [PDF]

, 2016
Variable patient responses to drugs are a key issue for medicine and for drug discovery and development. Personalised medicine, that is the selection of medicines for subgroups of patients so as to maximise drug efficacy and minimise toxicity, is a key ...
Abo, Abrahams, Andersson, Backshall, Bales, Clayton, Clayton, Coen, Condray, Coughtrie, Cunningham, Dai, Dona, Ellero-Simatos, Everett, Everett, Everett, Everett, Fiehn, Gamage, Gupta, Hao, Holmes, Holmes, Holmes, Huang, Iles, Ji, Joseph, Kaddurah-Daouk, Kaddurah-Daouk, Kaddurah-Daouk, Kaddurah-Daouk, Kapoor, Karas-Kuželički, Kettunen, Keun, Kwon, Lazarou, Lee, Lewis, Li, Lindon, Lindon, Lindon, Lindon, Lindon, Liu, Maruthur, McPhail, Miolo, Muhrez, Nam, Neavin, Nicholson, Nicholson, Park, Patel, Perlis, Phapale, Possamai, Puskarich, Rahmioglu, Rhee, Robinette, Rotroff, Rueedi, Salari, Serrano-Contreras, Shah, Shin, Shin, Sjöberg, Smith, Suhre, Suhre, Theodoridis, Trupp, Urban, Wang, Wang-Sattler, Wikoff, Wilson, Winnike, Yerges-Armstrong, Zhu   +85 more
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