Results 41 to 50 of about 2,106 (148)

Biomarker‐Based Prediction of OATP1B1 Activity in Clinical Routine—Investigating Coproporphyrins as Markers for Drug–Drug–Gene Interactions

Clinical Pharmacology &Therapeutics, EarlyView.
Coproporphyrin I (CPI) is an established endogenous biomarker for detecting drug–drug interactions (DDIs) involving the hepatic uptake transporter Organic Anion Transporting Polypeptide 1B1 (OATP1B1, gene SLCO1B1). While CPI has been extensively studied in healthy volunteers using controlled pre‐ and post‐OATP1B1‐inhibitor sampling, its applicability ...
Leila Potzel, Anina Zumtaugwald, Anna Bollinger, Chiara Jeiziner, Kurt E. Hersberger, Florine Wiss, Markus L. Lampert, Samuel S. Allemann, Henriette E. Meyer zu Schwabedissen, Céline K. Stäuble   +9 more
wiley   +1 more source

Proposed mechanism of action used by CXCL12 to drive myofibroblast phenoconversion.

, 2016
The canonical pathway driving myofibroblast differentiation is driven by TGF-β-mediated Smad and MEK/Erk signaling14. However, upon binding to CXCR4, CXCL12 promotes the transactivation of EGFR, potentially through MMP/ADAM as previously described by ...
Mehrnaz Gharaee-Kermani (118877), Jill A. Macoska (118895), Diego Almanza (3150834), Susan C. Patalano (3150831), José A. Rodríguez-Nieves (3150828)   +4 more
core   +1 more source

Impact of CYP2C19 and CYP3A4 Inhibitor Use on Clopidogrel Clinical Effectiveness in CYP2C19 Genotyped Patients Undergoing Percutaneous Coronary Intervention

Clinical Pharmacology &Therapeutics, EarlyView.
CYP2C19 and CYP3A4 contribute to clopidogrel bioactivation. CYP2C19 no‐function alleles diminish clopidogrel's antiplatelet effects and clinical effectiveness. Coadministration of either a CYP2C19 or a CYP3A4 inhibitor may also reduce clopidogrel's antiplatelet effects and lead to phenoconversion in patients without a CYP2C19 no‐function allele (normal/
Danwei Shao, Jean G. Malavé, Joseph S. Rossi, Francesco Franchi, Ellen C. Keeley, Dominick J. Angiolillo, George A. Stouffer, Larisa H. Cavallari, Craig R. Lee   +8 more
wiley   +1 more source

Autophagy in phenoconversion of differentiated and undifferentiated fibroblasts

The FASEB Journal, 2013
Cardiac fibroblasts phenoconvert to hypersecretory myofibroblasts and deposit matrix resulting in cardiac fibrosis and autophagy that is associated to fibroproliferative events. Autophagy inhibition was studied in both primary (P0) rat cardiac fibroblasts (PF) and mouse embryonic fibroblasts (MEF).
Shivika Gupta, Morvarid Kavosh, Shu‐Ru Chen, Saeid Ghavami, Sunil Rattan, Thomas Klonisch, Ian Dixon   +6 more
openaire   +1 more source

Tracking Genetic Parkinson's Disease with Molecular Imaging: A Systematic Review

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Parkinson's disease (PD) is a worldwide, complex neurodegenerative disorder influenced by both genetic and environmental factors. Around 15–20% of PD cases are linked to genetic mutations, providing insights into the disease's pathogenesis.
Chiara Meneghini, Luca Gallo, Arianna Sala, Enza Maria Valente, Micol Avenali, Silvia Paola Caminiti   +5 more
wiley   +1 more source

Autonomic dysfunction and phenoconversion in idiopathic REM sleep behavior disorder

Clinical Autonomic Research, 2020
REM sleep behavior disorder (RBD) is a common finding among patients with synucleinopathies. We aimed to determine the degree of autonomic dysfunction in patients presenting with idiopathic RBD (iRBD), and the predictive value of autonomic dysfunction for phenoconversion to a defined neurodegenerative disease.We searched our electronic medical record ...
Stuart J, McCarter, Tonette L, Gehrking, Erik K, St Louis, Mariana D, Suarez, Bradley F, Boeve, Michael H, Silber, Phillip A, Low, Wolfgang, Singer   +7 more
openaire   +3 more sources

Differential Progression of Neuroinflammation in Patients with Isolated Rapid‐Eye‐Movement Sleep Behavior Disorder

Movement Disorders, EarlyView.
Abstract Background Neuroinflammation, measured using [11C](R)‐PK11195 positron emission tomography (PET), has been reported in isolated rapid‐eye‐movement sleep behavior disorder (iRBD), but its temporal progression is unknown. Objective The aim was to assess longitudinal progression of neuroinflammation in iRBD patients and its relationship with ...
Andreas Myhre Baun, Alex Iranzo, Miriam Højholt Terkelsen, Rainer Hinz, Morten Gersel Stokholm, Kristian Stær, Mónica Serradel, Marit Otto, Kristina Bacher Svendsen, Alicia Garrido, Dolores Vilas, Arne Møller, Carles Gaig, Eduardo Tolosa, David J. Brooks, Per Borghammer, Simon Fristed Eskildsen, Nicola Pavese   +17 more
wiley   +1 more source

Table1_Pharmacogenetics and phenoconversion: the influence on side effects experienced by psychiatric patients.DOCX

, 2023
Introduction: Preventing side effects is important to ensure optimal psychopharmacotherapy and therapeutic adherence among psychiatric patients. Obtaining the pharmacogenetic profile of CYP2C19 and CYP2D6 can play an important role in this.
Kay R. Wagelaar (16881435), Ingeborg Wilting, Wiepke Cahn (155467), Kay R. Wagelaar, Ingeborg Wilting (11578330), Hannelotte W. Hut, Vera H. M. Deneer (10029386), Hannelotte W. Hut (16881432), Manon G. den Uil, Manon G. den Uil (16881429), Vera H. M. Deneer, Heshu Abdullah-Koolmees (10029377), Heshu Abdullah-Koolmees, Wiepke Cahn   +13 more
core   +1 more source

[18F]Fluorodeoxyglucose positron emission tomography ([18F]FDG PET) Characterizes Neurodegeneration Levels Across the α‐Synucleinopathy Continuum

Movement Disorders, EarlyView.
Abstract Background [18F]Fluorodeoxyglucose positron emission tomography ([18F]FDG PET) represents an endorsed neurodegeneration biomarker in neuronal α‐synucleinopathies. Idiopathic/isolated rapid eye movement (REM) sleep behavior disorder (iRBD) represents a prodromal stage of such disorders.
Beatrice Orso, Ignacio Roura, Pietro Mattioli, Francesco Famà, Federico Massa, Luigi Lorenzini, Andrea Brugnolo, Nicola Girtler, Mattia Losa, Stefano Raffa, Luca Sofia, Monica Roascio, Gabriele Arnulfo, Silvia Morbelli, Matteo Pardini, Dario Arnaldi   +15 more
wiley   +1 more source

Progression of Motor and Cognitive Functions in Isolated REM Sleep Behavior Disorder: A 7‐Year Prospective Matched Cohort Study

Movement Disorders, EarlyView.
Abstract Background Although clinical markers (eg, motor and cognitive impairment) in isolated rapid eye movement sleep behavior disorder (iRBD) are associated with faster phenoconversion, their longitudinal trajectory patterns (linear or nonlinear) remain unclear.
Li Zhou, Yaping Liu, Bei Huang, Jing Wang, Shi Tang, Yuhua Yang, Siyi Gong, Steven W.H. Chau, Joey W.Y. Chan, Mandy W.M. Yu, Jessie C.C. Tsang, Shirley Xin Li, Siu Ping Lam, Vincent C.T. Mok, Karen K.Y. Ma, Anne Y.Y. Chan, Jihui Zhang, Yun Kwok Wing   +17 more
wiley   +1 more source