Results 61 to 70 of about 3,015 (189)

Clinical and dopaminergic imaging characteristics of the FARPRESTO cohort of trial-ready idiopathic rapid eye movement sleep behavior patients [PDF]

, 2023
Introduction: Idiopathic/isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is considered the prodromal stage of alpha-synucleinopathies. Thus, iRBD patients are the ideal target for disease-modifying therapy. The risk FActoRs PREdictive of
Antelmi, Elena, Arnaldi, Dario, Baldelli, Luca, Bonanni, Enrica, Brunetti, Valerio, Capriglia, Elena, Casaglia, Elisa, Ferini-Strambi, Luigi, Fernandes, Mariana, Figorilli, Michela, Liguori, Claudio, Marelli, Sara, Mattioli, Pietro, Morbelli, Silvia, Pardini, Matteo, Placidi, Fabio, Plazzi, Giuseppe, Provini, Federica, Puligheddu, Monica, Rubino, Annalisa, Rustioni, Valter, Serra, Alessandra, Terzaghi, Michele   +22 more
core   +1 more source

Similar Progression of Morphological and Metabolic Phenotype in R6/2 Mice with Different CAG Repeats Revealed by In Vivo Magnetic Resonance Imaging and Spectroscopy. [PDF]

, 2016
BACKGROUND: Huntington's disease (HD) is caused by an unstable polyglutamine (CAG) repeat in the HD gene, whereby a CAG repeat length greater than ∼36 leads to the disease.
Morton, A Jennifer, Sawiak, Stephen J, Wood, Nigel I   +2 more
core   +1 more source

Lipids under stress - a lipidomic approach for the study of mood disorders [PDF]

, 2015
The emerging field of lipidomics has identified lipids as key players in disease physiology. Their physicochemical diversity allows precise control of cell structure and signaling events through modulation of membrane prop- erties and trafficking of ...
Antonny, Arevalo, Bazinet, Bessa, Björkhem, Bligh, Bozek, Brügger, Buchenauer, Catania, Cermenati, Cerqueira, Cerruti, Chan, Chang, Choi, Chuang, Dawson, De Kroon, Delisi, Di Paolo, Di Paolo, Dias, Dias-Ferreira, Dietschy, Dunkley, Fahy, Fahy, Feder, Giovacchini, Green, Green, Guan, Gulbins, Han, Hannun, Hartmann, Heverin, Holthuis, Holthuis, Huang, Karran, Kassas, Kay, Kielkowska, Kim, Kloda, Klose, Kodigepalli, Kornhuber, Lam, Lamaziere, Lee, Lev, Levant, Little, Liu, Lupien, Lütjohann, Maceyka, Malcher-Lopes, Mapstone, McMahon, McNamara, Mesmin, Miller, Morel, Mouritsen, Movahed, Müller, Nestler, Nestler, Nguyen, Nicolson, Oliveira, Oliveira, Oliveira, Ortolani, Pinto, Piomelli, Popoli, Prasad, Prasad, Puri, Radhakrishnan, Ricart-Jané, Roozendaal, Sanchez, Sanchez-Mejia, Schauder, Schultz, Shevchenko, Simons, Simons, Sousa, Sousa, Sousa, Sousa, Subramanian, Sundaram, Takamori, Thatcher, Tiemeier, Van Meer, Vetrivel, Wakelam, Walter, Wenk, Wenk, Williamson, Wymann, Yang, Zhang, Zhang, Zolov   +114 more
core   +1 more source

‘Phenoconversion’ in adult patients with β‐thalassemia

American Journal of Hematology
Rate and risk factors for phenoconversion from non-transfusion-dependent β-thalassemia (NTDT) to transfusion-dependent β-thalassemia (TDT) during a 10-year follow up of adult patients in Italy.
Musallam, Khaled M., Barella, Susanna, Origa, Raffaella, Ferrero, Giovanni Battista, Lisi, Roberto, Pasanisi, Annamaria, Longo, Filomena, Gianesin, Barbara, Forni, Gian Luca, Valeria Pinto, Roberta Sciortino, Domenico Roberti, Lucia De Franceschi, Martina Culcasi   +13 more
openaire   +4 more sources

Pharmacist-Led Medication Evaluation Considering Pharmacogenomics and Drug-Induced Phenoconversion in the Treatment of Multiple Comorbidities: A Case Report

Medicina, 2021
Pharmacogenomic (PGx) information can guide drug and dose selection, optimize therapy outcomes, and/or decrease the risk of adverse drug events (ADEs). This report demonstrates the impact of a pharmacist-led medication evaluation, with PGx assisted by a ...
Nicole Marie Del Toro-Pagán, Adriana Matos, David Thacker, Jacques Turgeon, Nishita Shah Amin, Veronique Michaud   +5 more
doaj   +1 more source

Rating scales for behavioural symptoms in Huntington's Disease: critique and recommendations [PDF]

, 2016
Behavioral symptoms are an important feature of Huntington’s disease and contribute to impairment in quality of life. The Movement Disorder Society commissioned the assessment of the clinimetric properties of rating scales in Huntington’s disease in ...
Bachoud-Levi, Banaszkiewicz, Baudic, Beglinger, Beglinger, Beglinger, Blackwell, Brugger, Brusa, Burns, Callaghan, Chatterjee, Como, Craig, Craufurd, Curtis, Dale, Decruyenaere, Delmaire, Dominguez, DudokdeWit, Duff, Duijn, Duijn, Duijn, Duijn, Epping, Gargiulo, Gray, Group, Hamilton, Hamilton, Ho, Holl, Horowitz, Hubers, Jankovic, Justo, Kingma, Kloppel, Kulisevsky, Leroi, Levy, Litvan, Lucetti, Lundervold, Lundin, Marder, Mayberg, Mestre, Meyer, Moulton, Naarding, Nimmagadda, Orth, Paulsen, Paulsen, Peavy, Pflanz, Poudel, Reedeker, Reedeker, Rees, Reilmann, Rickards, Rickards, Schrag, Sitek, Sitek, Snaith, Souza, Spielberger, Sprengelmeyer, Starkstein, Stout, Tabrizi, Tippett, Vassos, Vitale, Watson, Wetzel, Wing, Wong, Yebenes, Zappacosta   +84 more
core   +1 more source

Biomarkers of conversion to alpha-synucleinopathy in isolated rapid-eye-movement sleep behaviour disorder [PDF]

, 2021
Patients with isolated rapid-eye-movement sleep behaviour disorder (RBD) are commonly regarded as being in the early stages of a progressive neurodegenerative disease involving \u3b1-synuclein pathology, such as Parkinson's disease, dementia with Lewy ...
Adler, Charles H., Antelmi, Elena, Arnaldi, Dario, Baldelli, Luca, Boeve, Bradley F., Cesari, Matteo, Dall'Antonia, Irene, Diederich, Nico J., Doppler, Kathrin, Dusek, Petr, Ferri, Raffaele, Gagnon, Jean-Francois, Gan-Or, Ziv, Hermann, Wiebke, Hoegl, Birgit, Hu, Michele T., Iranzo, Alex, Janzen, Annette, Kuzkina, Anastasia, Lee, Jee-Young, Leenders, Klaus L., Lewis, Simon J. G., Liguori, Claudio, Liu, Jun, Lo, Christine, Martens, Kaylena A. Ehgoetz, Miglis, Mitchell G., Nepozitek, Jiri, Oertel, Wolfgang H., Plazzi, Giuseppe, Provini, Federica, Puligheddu, Monica, Rolinski, Michal, Rusz, Jan, Stefani, Ambra, Summers, Rebekah L. S., Yoo, Dallah, Zitser, Jennifer   +37 more
core   +1 more source

Longitudinal changes in qualitative aspects of semantic fluency in presymptomatic and prodromal genetic frontotemporal dementia [PDF]

, 2023
Background: The semantic fluency test is one of the most widely used neuropsychological tests in dementia diagnosis. Research utilizing the qualitative, psycholinguistic information embedded in its output is currently underexplored in presymptomatic and ...
Giannini, Lucia A.A., Jiskoot, Lize C., Laenen, Sascha A.A.M., Pijnenburg, Yolande A.L., Poos, Jackie M., Satoer, Djaina D., Seelaar, Harro, van den Berg, Esther, van Hemmen, Judy, Vonk, Jet M.J.   +9 more
core   +2 more sources

Distinct Prescription Patterns Emerge Years Before ALS Diagnosis: A Nationwide Registry‐Based Study

Annals of Neurology, EarlyView.
Objective The prodromal phase of amyotrophic lateral sclerosis (ALS) is poorly defined. We aimed to characterize prescription drug use patterns in the pre‐diagnostic period by analyzing nationwide prescription data to identify the earliest divergence between individuals who developed ALS and matched healthy controls.
Magne Haugland Solheim, Trond Riise, Marianna Cortese, Ola Nakken, Ole‐Bjørn Tysnes, Jannicke Igland, Kjetil Bjornevik   +6 more
wiley   +1 more source

Renin–angiotensin system gene polymorphisms among Saudi patients with coronary artery disease [PDF]

, 2014
BACKGROUND: Idiopathic REM sleep behavior disorder is a prodromal stage of Parkinson's disease and dementia with Lewy bodies. Hyposmia, reduced dopamine transporter binding, and expression of the brain metabolic PD-related pattern were each associated ...
Della Rosa, Eidelberg, Frauscher, Gagnon, Holtbernd, Holtbernd, Huang, Hughes, Hummel, Iranzo, Iranzo, Iranzo, Iranzo, Ma, Mahlknecht, McKeith, Meles, Movement Disorder Society Task Force on Rating Scales for Parkinson's Disease, Niethammer, Ponsen, Postuma, Postuma, Schenck, Schenck, Spetsieris, Stiasny-Kolster, Stiasny-Kolster, Stoffers, Tang, Teune, Tripathi, Wu, Zande   +32 more
core   +4 more sources