Results 61 to 70 of about 2,455 (143)

Cognitive profile in idiopathic autonomic failure: relation with white matter hyperintensities and neurofilament levels

Annals of Clinical and Translational Neurology, 2022
Objective To disclose the nature of cognitive deficits in a cohort of patients with idiopathic autonomic failure (IAF) by exploring the relation among cognitive functions, cardiovascular autonomic failure (AF) and clinical progression to another α ...
Ilaria Cani, Luisa Sambati, Fiorina Bartiromo, Gian Maria Asioli, Simone Baiardi, Laura M. B. Belotti, Giulia Giannini, Pietro Guaraldi, Corinne Quadalti, Luciano Romano, Raffaele Lodi, Piero Parchi, Pietro Cortelli, Caterina Tonon, Giovanna Calandra‐Buonaura   +14 more
doaj   +1 more source

Ruxolitinib Pharmacokinetics and Exposure–Toxicity Relationship in Hematologic Malignancies and Immune‐Mediated Diseases: A Prospective Observational Study

Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 753-761, September 2026.
Ruxolitinib pharmacokinetics (PK) has been characterized in clinical trials but remains poorly documented in real‐world practice. This project aimed to investigate ruxolitinib PK in routine clinical practice, identify factors driving its variability, and explore exposure–response relationships to assess the potential role of therapeutic drug monitoring.
Jérémie Tachet, Sara C. Meyer, Francesco Grandoni, Emmanuel Haefliger, Monika Nagy‐Hulliger, Jörg P. Halter, Jakob R. Passweg, David Haefliger, Carine Bardinet, Laurent A. Decosterd, Monia Guidi, François R. Girardin   +11 more
wiley   +1 more source

Neurofilament light chain and cardiac MIBG uptake as predictors for phenoconversion in isolated REM sleep behavior disorder

, 2023
Background: Isolated rapid-eye-movement (REM) sleep behavior disorder (iRBD) is considered as a prodromal stage of either multiple system atrophy (MSA) or Lewy body disease (LBD; Parkinson's disease and dementia with Lewy bodies).
Ju Yeong Kim, Kim, JY, Kim, MH, Yoon, JH, Mi Hee Kim, Min Seung Kim, An, YS, Park, DG, Chang, J, Young-Sil An, Kim, MS, Jaerak Chang, Jung Han Yoon, Don Gueu Park   +13 more
core   +1 more source

Cognitive training and promoting a healthy lifestyle in isolated REM sleep behavior disorder: The randomized controlled trial CogTrAiL‐RBD

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is a prodromal phase of Lewy body diseases and linked to a high risk for cognitive decline. Therefore, iRBD provides a suitable window for early intervention. METHODS In the monocentric randomized controlled trial “Cognitive Training & a Healthy, Active Lifestyle ...
Anja Ophey, Sinah Röttgen, Konstantin Kufer, Julia Pauquet, Daniel Scharfenberg, Philipp Armbrust, Anastasia Kammerzell, Nathalie Knopf, Sandy Kollath, Philipp Sommer, Christopher E. J. Doppler, Ezequiel Farrher, Aline Seger, N. Jon Shah, David Zopfs, Kathrin Reetz, Gereon R. Fink, Michael Sommerauer, Elke Kalbe   +18 more
wiley   +1 more source

Longitudinal network changes and phenoconversion risk in isolated REM sleep behavior disorder

Nature Communications
Isolated rapid eye movement sleep behavior disorder is a prodrome of α-synucleinopathies. Using positron emission tomography, we assessed changes in Parkinson’s disease-related motor and cognitive metabolic networks and caudate/putamen dopaminergic input
Chris C. Tang, Yoshikazu Nakano, An Vo, Nha Nguyen, Katharina A. Schindlbeck, Paul J. Mattis, Kathleen L. Poston, Jean-François Gagnon, Ronald B. Postuma, Martin Niethammer, Yilong Ma, Shichun Peng, Vijay Dhawan, David Eidelberg   +13 more
doaj   +1 more source

Biomarker‐Based Prediction of OATP1B1 Activity in Clinical Routine—Investigating Coproporphyrins as Markers for Drug–Drug–Gene Interactions

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 492-500, August 2026.
Coproporphyrin I (CPI) is an established endogenous biomarker for detecting drug–drug interactions (DDIs) involving the hepatic uptake transporter Organic Anion Transporting Polypeptide 1B1 (OATP1B1, gene SLCO1B1). While CPI has been extensively studied in healthy volunteers using controlled pre‐ and post‐OATP1B1‐inhibitor sampling, its applicability ...
Leila Potzel, Anina Zumtaugwald, Anna Bollinger, Chiara Jeiziner, Kurt E. Hersberger, Florine Wiss, Markus L. Lampert, Samuel S. Allemann, Henriette E. Meyer zu Schwabedissen, Céline K. Stäuble   +9 more
wiley   +1 more source

PREDICT‐PD: A Two‐Stage Approach to Early Identification of Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Sasivimol Virameteekul, Sheena Waters, Brook Huxford, Ashvin Kuri, Manuela Tan, Laura Pérez‐Carbonell, Eduardo de Pablo‐Fernández, Anette Schrag, Alastair J. Noyce, Cristina Simonet   +9 more
wiley   +1 more source

Generalized EEG Slowing Across Phasic REM Sleep, Not Subjective RBD Severity, Predicts Neurodegeneration in Idiopathic RBD

Nature and Science of Sleep, 2022
Si-Yi Gong,1,* Yun Shen,1,* Han-Ying Gu,1 Sheng Zhuang,1 Xiang Fu,1,2 Qiao-Jun Wang,1 Cheng-Jie Mao,1 Hua Hu,1 Yong-Ping Dai,1 Chun-Feng Liu1– 3 1Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated ...
Gong SY, Shen Y, Gu HY, Zhuang S, Fu X, Wang QJ, Mao CJ, Hu H, Dai YP, Liu CF   +9 more
doaj  

Liquid Chromatography–Tandem Mass Spectrometry Quantification of Diet‐Derived CYP2D6 Biomarkers for Clinical Phenotyping in Japanese Subjects

Clinical and Translational Science, Volume 19, Issue 8, August 2026.
ABSTRACT The enzymatic activity of cytochrome P450 2D6 (CYP2D6) exhibits substantial interindividual variation, which influences drug efficacy and the risk of adverse drug reactions to various therapeutics. While current protocols for CYP2D6 genotyping or CYP2D6 phenotyping provide useful information, less invasive and simpler tools are desirable for ...
Masaki Kumondai, Nagomi Hayashi, Yotaro Matsumoto, Akiko Ebata, Miku Sato, Narumi Harada‐Shoji, Hiroshi Tada, Minoru Miyashita, Takanori Ishida, Masamitsu Maekawa, Yoshihisa Tomioka, Nariyasu Mano   +11 more
wiley   +1 more source

‘Phenoconversion’ in adult patients with β‐thalassemia

: Rate and risk factors for phenoconversion from non-transfusion-dependent β-thalassemia (NTDT) to transfusion-dependent β-thalassemia (TDT) during a 10-year follow up of adult patients in ...
Barella, Susanna, Lisi, Roberto, Pasanisi, Annamaria, Lucia De Franceschi, Domenico Roberti, Martina Culcasi, Ferrero, Giovanni Battista, Gianesin, Barbara, Musallam, Khaled M., Origa, Raffaella, Valeria Pinto, Longo, Filomena, Forni, Gian Luca, Roberta Sciortino   +13 more
core   +1 more source