Results 81 to 90 of about 3,015 (189)

Early Autonomic Burden in Prodromal Parkinson's Disease Predicts Cognitive Impairment

Movement Disorders, EarlyView.
Abstract Background Autonomic dysfunction is a known contributor to cognitive impairment in Parkinson's disease (PD), but its impact during prodromal stage is unknown. Objective The aim was to determine whether early autonomic burden predicts incident cognitive impairment in prodromal PD.
A. Enrique Martinez‐Nunez, Kelly A. Mills, Joseph Seemiller, Christopher B. Morrow, Gregory M. Pontone, Abhimanyu Mahajan   +5 more
wiley   +1 more source

Cognitive profile in idiopathic autonomic failure: relation with white matter hyperintensities and neurofilament levels

Annals of Clinical and Translational Neurology, 2022
Objective To disclose the nature of cognitive deficits in a cohort of patients with idiopathic autonomic failure (IAF) by exploring the relation among cognitive functions, cardiovascular autonomic failure (AF) and clinical progression to another α ...
Ilaria Cani, Luisa Sambati, Fiorina Bartiromo, Gian Maria Asioli, Simone Baiardi, Laura M. B. Belotti, Giulia Giannini, Pietro Guaraldi, Corinne Quadalti, Luciano Romano, Raffaele Lodi, Piero Parchi, Pietro Cortelli, Caterina Tonon, Giovanna Calandra‐Buonaura   +14 more
doaj   +1 more source

Immunodepletion and hypoxia preconditioning of mouse vompact bone cells as a novel protocol to isolate highly immunosuppressive mesenchymal stem cells [PDF]

, 2017
Prepublished on Liebert Instant Online December 21, 2016Compact bones (CB) are major reservoirs of mouse mesenchymal stem cells (mMSC). Here, we established a protocol to isolate MSC from CB and tested their immunosuppressive potential.
Coates, P., Grey, S., Gronthos, S., Rojas-Canales, D., Sivanathan, K.   +4 more
core   +1 more source

In Vivo Mapping of Catecholaminergic Loss and Iron Deposition in Huntington's Disease

Movement Disorders, EarlyView.
Abstract Background The pathophysiology of Huntington's disease (HD) remains obscure. Magnetic resonance imaging (MRI) can reveal in vivo molecular changes related to disease pathology. Objectives To investigate catecholaminergic neuronal integrity and subcortical brain iron accumulation in HD employing neuromelanin‐sensitive MRI, and quantitative ...
Edoardo R. de Natale, Heather Wilson, Efstratios Karavasilis, Athanasia Liozidou, Chrisoula Kartanou, Georgios Velonakis, Jens Kuhle, Ioannis Zalonis, Georgia Karadima, Leonidas Stefanis, Georgios Koutsis, Marios Politis   +11 more
wiley   +1 more source

Precision anesthesia and pharmacogenomics: a scoping review of personalized drug response

Frontiers in Anesthesiology
BackgroundAnesthetic agent selection and dosing have historically relied on empirical models without taking into account inter-individual variability in drug response, leading to adverse drug reactions (ADRs).
Sarina Nikzad, Ofelia Loani Elvir-Lazo, Robert Wong   +2 more
doaj   +1 more source

Preventing amyotrophic lateral sclerosis:iInsights from pre-symptomatic neurodegenerative diseases [PDF]

, 2021
Significant progress has been made in understanding the pre-symptomatic phase of amyotrophic lateral sclerosis. While much is still unknown, advances in other neurodegenerative diseases offer valuable insights.
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core   +2 more sources

Differential Progression of Neuroinflammation in Patients with Isolated Rapid‐Eye‐Movement Sleep Behavior Disorder

Movement Disorders, EarlyView.
Abstract Background Neuroinflammation, measured using [11C](R)‐PK11195 positron emission tomography (PET), has been reported in isolated rapid‐eye‐movement sleep behavior disorder (iRBD), but its temporal progression is unknown. Objective The aim was to assess longitudinal progression of neuroinflammation in iRBD patients and its relationship with ...
Andreas Myhre Baun, Alex Iranzo, Miriam Højholt Terkelsen, Rainer Hinz, Morten Gersel Stokholm, Kristian Stær, Mónica Serradel, Marit Otto, Kristina Bacher Svendsen, Alicia Garrido, Dolores Vilas, Arne Møller, Carles Gaig, Eduardo Tolosa, David J. Brooks, Per Borghammer, Simon Fristed Eskildsen, Nicola Pavese   +17 more
wiley   +1 more source

[18F]Fluorodeoxyglucose positron emission tomography ([18F]FDG PET) Characterizes Neurodegeneration Levels Across the α‐Synucleinopathy Continuum

Movement Disorders, EarlyView.
Abstract Background [18F]Fluorodeoxyglucose positron emission tomography ([18F]FDG PET) represents an endorsed neurodegeneration biomarker in neuronal α‐synucleinopathies. Idiopathic/isolated rapid eye movement (REM) sleep behavior disorder (iRBD) represents a prodromal stage of such disorders.
Beatrice Orso, Ignacio Roura, Pietro Mattioli, Francesco Famà, Federico Massa, Luigi Lorenzini, Andrea Brugnolo, Nicola Girtler, Mattia Losa, Stefano Raffa, Luca Sofia, Monica Roascio, Gabriele Arnulfo, Silvia Morbelli, Matteo Pardini, Dario Arnaldi   +15 more
wiley   +1 more source

Factors associated with phenoconversion of idiopathic rapid eye movement sleep behavior disorder: a prospective study

npj Parkinson's Disease
This study explores the effect of risk factors on the progression of idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) to α-synucleinopathies in a Chinese cohort.
Yuan Yuan, Yuan Li, Hui Zhang, Yajie Zang, Xiaonan Liu, Yue Hou, Shuqin Zhan, Yanning Cai, Wei Mao, Piu Chan   +9 more
doaj   +1 more source

CD4+ T-cell transcription factors predict phenoconversion in idiopathic rapid eye movement sleep behavior disorder

Future Science OA
Aim: Early biomarkers of phenoconversion to neurodegeneration are crucial to identify individuals at high risk. In patients with idiopathic REM sleep behavior disorder (iRBD), the strongest risk factor for neurodegeneration, CD4+ T cells exhibit a ...
Monica Pinoli, Michele Terzaghi, Franca Marino, Cristoforo Comi, Maurizio Versino, Marco Cosentino   +5 more
doaj   +1 more source