Results 81 to 90 of about 2,663 (168)

Signaling Mechanisms Underlying Cxcl5-Mediated Fibroblast to Myofibroblast Phenoconversion

, 2017
Lower urinary tract symptoms (LUTS) comprise a number of medical conditions including weak stream, incomplete bladder voiding, and nocturia that affect quality of life and can progress to more severe symptoms if left untreated.
Belford, Timothy K.
core   +1 more source

Pharmacogenomics in Dentistry: From CYP‐Mediated Drug Response to Precision Prescribing in Oral Healthcare

Oral Diseases, EarlyView.
ABSTRACT Objective This narrative review critically assesses the clinical relevance of pharmacogenomics within dental genomics, distinguishing clinically actionable applications from emerging or investigational findings. Materials and Methods A targeted literature review was conducted in PubMed/MEDLINE, Scopus and Embase for publications from January ...
Giorgia Pieretto, Jessica Cusato, Martina Sansavini, Christian Bacci   +3 more
wiley   +1 more source

Longitudinal network changes and phenoconversion risk in isolated REM sleep behavior disorder

Nature Communications
Isolated rapid eye movement sleep behavior disorder is a prodrome of α-synucleinopathies. Using positron emission tomography, we assessed changes in Parkinson’s disease-related motor and cognitive metabolic networks and caudate/putamen dopaminergic input
Chris C. Tang, Yoshikazu Nakano, An Vo, Nha Nguyen, Katharina A. Schindlbeck, Paul J. Mattis, Kathleen L. Poston, Jean-François Gagnon, Ronald B. Postuma, Martin Niethammer, Yilong Ma, Shichun Peng, Vijay Dhawan, David Eidelberg   +13 more
doaj   +1 more source

CD4+ T-cell transcription factors as early predictors of phenoconversion in idiopathic rapid eye movement sleep behaviour disorder [version 2; peer review: 2 approved]

F1000Research
In this datanote we present data from 31 iRBD (idiopathic Rapid eye movement (REM) sleep Behaviour Disorder) patients followed throughout three years to assess their eventual phenoconversion to Parkinson’s disease and other established neurodegenerative ...
Maurizio Versino, Cristoforo Comi, Franca Marino, Michele Terzaghi, Monica Pinoli, Marco Cosentino   +5 more
doaj   +1 more source

Neurofilament Light Protein Predicts Disease Progression in Idiopathic REM Sleep Behavior Disorder

Journal of Parkinson’s Disease, 2023
Background: Idiopathic rapid eye movement sleep behavior disorder (iRBD) is increasingly recognized as a manifestation preceding the α-synucleinopathies like Parkinson’s disease (PD).
Xuan Zhang, Li Ma, Danqi Liang, Bingxin Song, Jingshan Chen, Yaqin Huang, Lin Xu, Peng Zhao, Wei Wu, Nan Zhang, Rong Xue   +10 more
doaj   +1 more source

Clinical Functional Assignment of TPMT and NUDT15 Alleles by the Clinical Pharmacogenetics Implementation Consortium Pharmacogene Curation Expert Panel

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1427-1437, November 2026.
The Clinical Pharmacogenetics Implementation Consortium (CPIC) TPMT/NUDT15 Pharmacogene Curation Expert Panel (PCEP) conducted a comprehensive review of clinical, laboratory, and computational evidence to determine the clinical function assignments for TPMT and NUDT15 star alleles.
Bailey M. Tibben, Maud Maillard, Victoria M. Pratt, Ann M. Moyer, Debbie M. Figueroa, Michelle Whirl‐Carrillo, Andrea Gaedigk, Gabriele Stocco, Matthias Schwab, Kelly E. Caudle, Jun J. Yang   +10 more
wiley   +1 more source

Practical Considerations for the Design, Conduct, and Reporting of Clinical Pharmacokinetic Drug–Drug Interaction Studies in Drug Development

The Journal of Clinical Pharmacology, Volume 66, Issue 11, November 2026.
Abstract Clinical pharmacokinetic drug–drug interaction (PK‐DDI) studies are frequently required in drug development when metabolizing enzymes and transporters determine pharmacokinetics. Drugs can be victims, perpetrators, or victims and perpetrators, of PK‐DDIs, so the clinical consequences of these interactions, particularly the risks of severe ...
Thomas M. Polasek, John O. Miners
wiley   +1 more source

Serum Neurofilament Light Chain and GFAP in Amyotrophic Lateral Sclerosis on a Commercial ECLIA Platform

Muscle &Nerve, Volume 74, Issue 5, Page 1398-1405, November 2026.
ABSTRACT Introduction/Aims In amyotrophic lateral sclerosis (ALS), SIMOA‐based studies show that baseline serum neurofilament light chain (NfL) predicts the revised ALS Functional Rating Scale (ALSFRS‐R) decline rate and survival. The Roche Elecsys electrochemiluminescence immunoassay (ECLIA) reports values approximately six‐fold lower; cross‐platform ...
Nicholas S. Streicher
wiley   +1 more source

Factors associated with phenoconversion of idiopathic rapid eye movement sleep behavior disorder: a prospective study

npj Parkinson's Disease
This study explores the effect of risk factors on the progression of idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) to α-synucleinopathies in a Chinese cohort.
Yuan Yuan, Yuan Li, Hui Zhang, Yajie Zang, Xiaonan Liu, Yue Hou, Shuqin Zhan, Yanning Cai, Wei Mao, Piu Chan   +9 more
doaj   +1 more source

Time to Move Upstream? A Framework for Expanding the Focus of Freezing of Gait to Prodromal, Subclinical, and Pre‐FOG Stages

European Journal of Neuroscience, Volume 64, Issue 9, November 2026.
Freezing of gait (FOG) is conceptualized as an upstream process evolving from vulnerability (Stages −3, prodromal), to subclinical (Stage −2) to downstream FOG expression (Stages −1, pre‐FOG and Stage 0, FOG episode). Earlier stages reflect underlying susceptibility, whereas later stages reflect the dynamic unfolding of freezing episodes.
Jeffrey M. Hausdorff, Kaylena A. Ehgoetz Martens, Moran Gilat, Jorik Nonnekes, Martina Mancini, J. Lucas McKay, Pieter Ginis, Jamie L. Adams, Jennifer R. Mammen, Erika E. Howe, Simon J. G. Lewis, Fay Horak, Alice Nieuwboer   +12 more
wiley   +1 more source