Results 81 to 90 of about 1,862 (162)

Dynamic phenotype monitoring to prevent genotype–phenotype discrepancies in pharmacogenetic-guided drug therapy

Frontiers in Pharmacology
BackgroundOne of the limiting factors for the clinical application of pharmacogenomics (PGx) is phenoconversion, i.e., the dynamic discrepancy between genotype-predicted and actual drug-metabolizing phenotypes.
Pálma Porrogi
doaj   +1 more source

Illustrative and historic cases of phenoconversion.

American journal of translational research
Intersubject variability in drug response, whether related to efficacy or toxicity, is well recognized clinically. Over the years, drug selection from our pharmacologic armamentarium has moved from providers' preferred choices to more personalized treatments as clinicians' decisions are guided by data from clinical trials.
Veronique, Michaud, Pamela, Dow, Jacques, Turgeon   +2 more
openaire   +1 more source

Progression trajectories from prodromal to overt synucleinopathies: a longitudinal, multicentric brain [18F]FDG-PET study

npj Parkinson's Disease
The phenoconversion trajectory from idiopathic/isolated Rapid eye movement (REM) sleep behavior disorder (iRBD) towards either Parkinson’s Disease (PD) or Dementia with Lewy Bodies (DLB) is currently uncertain.
Beatrice Orso, Pietro Mattioli, Eun-Jin Yoon, Yu Kyeong Kim, Heejung Kim, Jung Hwan Shin, Ryul Kim, Francesco Famà, Andrea Brugnolo, Federico Massa, Agostino Chiaravalloti, Mariana Fernandes, Matteo Spanetta, Fabio Placidi, Matteo Pardini, Matteo Bauckneht, Silvia Morbelli, Jee-Young Lee, Claudio Liguori, Dario Arnaldi   +19 more
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Effect of CYP2D6, 2C19, and 3A4 Phenoconversion in Drug-Related Deaths

Toxics
Molecular autopsy is a very important tool in forensic toxicology. However, many determinants, such as co-medication and physiological parameters, should be considered for optimal results. These determinants could cause phenoconversion (PC), a discrepancy between the real metabolic profile after phenoconversion and the phenotype determined by the ...
Sanaa M. Aly, Benjamin Hennart, Jean-Michel Gaulier, Delphine Allorge   +3 more
openaire   +4 more sources

Understanding variation in metoprolol response: CYP2D6, drug interactions, and phenoconversion

Pharmacogenomics
Metoprolol, a β1-selective blocker, is widely used for treating cardiovascular and non-cardiovascular conditions. Its pharmacokinetics (PK) and pharmacodynamics (PD) vary significantly between individuals, in part due to CYP2D6 genetic polymorphisms.
Bayan Azizi, David E. Lanfear, Jasmine A. Luzum   +2 more
openaire   +2 more sources

Insular monoaminergic deficits in prodromal α‐synucleinopathies

Annals of Clinical and Translational Neurology
Methods This study assessed data from two cohorts of patients with alpha‐synucleinopathies (University of Brescia and University of Rome Tor‐Vergata cohorts).
Andrea Pilotto, Alice Galli, Cinzia Zatti, Fabio Placidi, Francesca Izzi, Enrico Premi, Silvia P. Caminiti, Luca Presotto, Andrea Rizzardi, Marcello Catania, Alessandro Lupini, Leandro Purin, Maria P. Pasolini, Nicola B. Mercuri, Agostino Chiaravalotti, Mariana Fernandes, Carmen Calvello, Silvia Lucchini, Francesco Bertagna, Barbara Paghera, Daniela Perani, Daniela Berg, Alessandro Padovani, Claudio Liguori   +23 more
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Blunted tachycardia and cardiac sympathetic denervation in isolated rapid eye movement sleep behavior disorder

BMC Neurology
Background Isolated rapid eye movement sleep behavior disorder (iRBD) serves as a prodromal phase of Parkinson’s disease (PD) and dementia with Lewy bodies (DLB).
Shota Saeda, Yukiyoshi Sumi, Koichi Fujiwara, Hiroshi Kadotani   +3 more
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Bowel movement frequency and difficult defecation using constipation assessment scale in patients with isolated REM sleep behavior disorder

Clinical Parkinsonism & Related Disorders
Introduction: This study evaluated constipation, including reduced bowel movement frequency and difficult defecation, in patients with isolated rapid eye movement sleep behavior disorder (IRBD), which is prodromal Parkinson’s disease (PD) or dementia ...
Tomoyuki Miyamoto, Itsuo Nakajima, Takuo Arikawa, Masayuki Miyamoto   +3 more
doaj   +1 more source

Motor features that distinguish isolated REM sleep behavior disorder patients from healthy controls: A systematic review

Journal of Parkinson’s Disease
Individuals with isolated REM sleep behavior disorder (iRBD) are at high risk of developing α-synucleinopathies, particularly Parkinson's disease (PD) and dementia with Lewy bodies (DLB).
Salma Elasfar, Hajr Hameed, Kaylena Ehgoetz Martens   +2 more
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Gait Analysis with Wearable Sensors in Isolated REM Sleep Behavior Disorder Associated with Phenoconversion: An Explorative Study

Journal of Parkinson’s Disease
Background: Gait disturbance is a vital characteristic of motor manifestation in α – synucleinopathies, especially Parkinson’s disease. Subtle gait alterations are present in isolated rapid eye movement sleep behavior disorder (iRBD) patients before ...
Shanshan Cen, Hui Zhang, Yuan Li, Zhuqin Gu, Yuan Yuan, Zheng Ruan, Yanning Cai, Jagadish K. Chhetri, Shuying Liu, Wei Mao, Piu Chan   +10 more
doaj   +1 more source