Results 81 to 90 of about 2,455 (143)

Presymptomatic Amyotrophic Lateral Sclerosis: From Early Biomarker Detection to Phenoconversion Prediction

Diagnostics
Amyotrophic lateral sclerosis (ALS) usually enters diagnostic pathways after motor symptoms emerge, by which time neural injury has been ongoing. Long-term hereditary ALS cohorts show that some pathogenic-variant carriers may show elevated neurofilament ...
Min Chen, Hexian Li, Qingwen Jin
doaj   +1 more source

Editorial: Prodromal stage of neurodegenerative proteinopathies: from bench to bedside

Frontiers in Neuroscience, 2023
Bin Xu, Bin Xu, Seyed-Mohammad Fereshtehnejad, Seyed-Mohammad Fereshtehnejad, Yashar Zeighami, Yashar Zeighami   +5 more
doaj   +1 more source

Insular monoaminergic deficits in prodromal α‐synucleinopathies

Annals of Clinical and Translational Neurology
Methods This study assessed data from two cohorts of patients with alpha‐synucleinopathies (University of Brescia and University of Rome Tor‐Vergata cohorts).
Andrea Pilotto, Alice Galli, Cinzia Zatti, Fabio Placidi, Francesca Izzi, Enrico Premi, Silvia P. Caminiti, Luca Presotto, Andrea Rizzardi, Marcello Catania, Alessandro Lupini, Leandro Purin, Maria P. Pasolini, Nicola B. Mercuri, Agostino Chiaravalotti, Mariana Fernandes, Carmen Calvello, Silvia Lucchini, Francesco Bertagna, Barbara Paghera, Daniela Perani, Daniela Berg, Alessandro Padovani, Claudio Liguori   +23 more
doaj   +1 more source

Blunted tachycardia and cardiac sympathetic denervation in isolated rapid eye movement sleep behavior disorder

BMC Neurology
Background Isolated rapid eye movement sleep behavior disorder (iRBD) serves as a prodromal phase of Parkinson’s disease (PD) and dementia with Lewy bodies (DLB).
Shota Saeda, Yukiyoshi Sumi, Koichi Fujiwara, Hiroshi Kadotani   +3 more
doaj   +1 more source

Bowel movement frequency and difficult defecation using constipation assessment scale in patients with isolated REM sleep behavior disorder

Clinical Parkinsonism & Related Disorders
Introduction: This study evaluated constipation, including reduced bowel movement frequency and difficult defecation, in patients with isolated rapid eye movement sleep behavior disorder (IRBD), which is prodromal Parkinson’s disease (PD) or dementia ...
Tomoyuki Miyamoto, Itsuo Nakajima, Takuo Arikawa, Masayuki Miyamoto   +3 more
doaj   +1 more source

Motor features that distinguish isolated REM sleep behavior disorder patients from healthy controls: A systematic review

Journal of Parkinson’s Disease
Individuals with isolated REM sleep behavior disorder (iRBD) are at high risk of developing α-synucleinopathies, particularly Parkinson's disease (PD) and dementia with Lewy bodies (DLB).
Salma Elasfar, Hajr Hameed, Kaylena Ehgoetz Martens   +2 more
doaj   +1 more source

Relationship of Mediterranean diet and caloric intake to phenoconversion in Huntington disease

, 2013
IMPORTANCE: Adherence to Mediterranean-type diet (MeDi) may delay onset of Alzheimer and Parkinson diseases. Whether adherence to MeDi affects time to phenoconversion in Huntington disease (HD), a highly penetrant, single-gene disorder, is unknown ...
Eberly, S., Shoulson, I., Marder, K., Scarmeas, N., Tanner, C.M., Oakes, D., Gu, Y.   +6 more
core   +1 more source

Gait Analysis with Wearable Sensors in Isolated REM Sleep Behavior Disorder Associated with Phenoconversion: An Explorative Study

Journal of Parkinson’s Disease
Background: Gait disturbance is a vital characteristic of motor manifestation in α – synucleinopathies, especially Parkinson’s disease. Subtle gait alterations are present in isolated rapid eye movement sleep behavior disorder (iRBD) patients before ...
Shanshan Cen, Hui Zhang, Yuan Li, Zhuqin Gu, Yuan Yuan, Zheng Ruan, Yanning Cai, Jagadish K. Chhetri, Shuying Liu, Wei Mao, Piu Chan   +10 more
doaj   +1 more source

Visuospatial dysfunction predicts dementia-first phenoconversion in isolated REM sleep behaviour disorder

Objective: While isolated rapid eye movement sleep behaviour disorder (iRBD) is known as a prodrome of α-synucleinopathies, the prediction for its future phenoconversion to parkinsonism-first or dementia-first subtype remains a challenge.
Chan, Joey WY, Mok, Vincent, Zhou, Li, Wing, Yun Kwok, Liu, Yaping, Tang, Shi, Huang, Bei, Feng, Hongliang, Li, Shirley X, Wang, Jing, Chau, Steven WH, Zhang, Jihui   +11 more
core   +1 more source

Understanding variation in metoprolol response: CYP2D6, drug interactions, and phenoconversion

Metoprolol, a β1-selective blocker, is widely used for treating cardiovascular and non-cardiovascular conditions. Its pharmacokinetics (PK) and pharmacodynamics (PD) vary significantly between individuals, in part due to CYP2D6 genetic polymorphisms.
Lanfear, David E, Luzum, Jasmine A, Azizi, Bayan   +2 more
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