Results 91 to 100 of about 2,663 (168)

The Relevance of Integrating CYP2C19 Phenoconversion Effects into Clinical Pharmacogenetics

Pharmacopsychiatry
Abstract Introduction CYP2D6 and CYP2C19 functional status as defined by genotype is modulated by phenoconversion (PC) due to pharmacokinetic interactions. As of today, there is no data on the effect size of PC for CYP2C19 functional status.
Scherf-Clavel, Maike, Weber, Heike, Unterecker, Stefan, Frantz, Amelie, Eckert, Andreas, Reif, Andreas, Deckert, Jürgen, Hahn, Martina   +7 more
openaire   +2 more sources

Clinical Trajectory of Late‐Onset Delusional Disorder Toward Evolving Dementia With Lewy Bodies

Psychogeriatrics, Volume 26, Issue 6, November 2026.
ABSTRACT Recent clinical observations indicate that late‐onset psychosis can precede the onset of dementia with Lewy bodies (DLB). However, its longitudinal clinical trajectory remains poorly understood. Delusional disorder (DD) in older adults is relatively uncommon and poor insight frequently leads to refusal of psychiatric care, limiting available ...
Hiroshige Fujishiro, Kazuhiro Takeda, Kuniyuki Iwata‐Endo, Shusei Arafuka, Seiko Miyata, Kunihiro Iwamoto, Youta Torii, Shuji Iritani   +7 more
wiley   +1 more source

‘Phenoconversion’ in adult patients with β-thalassemia

, 2023
To the Editor: Patients with clinically significant forms of β-thalassemia have been historically classified as having a β-thalassemia major or β-thalassemia intermedia phenotype, with the first primarily referring to patients who present with severe anemia during early childhood and require lifelong transfusion therapy and the latter relating to ...
Khaled M. Musallam, Susanna Barella, Raffaella Origa, Giovanni Battista Ferrero, Roberto Lisi, Annamaria Pasanisi, Filomena Longo, Barbara Gianesin, Gian Luca Forni, Lucia De Franceschi   +9 more
openaire   +1 more source

The role of club cell phenoconversion and migration in idiopathic pulmonary fibrosis

Aging, 2016
Idiopathic pulmonary fibrosis (IPF) is an age-related multifactorial disease featuring non-uniform lung fibrosis. The decisive cellular events at early stages of IPF are poorly understood. While the involvement of club cells in IPF pathogenesis is unclear, their migration has been associated with lung fibrosis.
Fukumoto, Jutaro, Soundararajan, Ramani, Leung, Joseph, Cox, Ruan, Jr., Mahendrasah, Sanjay, Muthavarapu, Neha, Herrin, Travis, Czachor, Alexander, Tan, Lee C., Hosseinian, Nima, Patel, Priyanshi, Gone, Jayanthraj, Breitzig, Mason T., Cho, Young, Cooke, Andrew J., Galam, Lakshmi, Narala, Venkata Ramireddy, Pathak, Yashwant, Lockey, Richard F., Kolliputi, Narasaiah   +19 more
openaire   +3 more sources

Generalized EEG Slowing Across Phasic REM Sleep, Not Subjective RBD Severity, Predicts Neurodegeneration in Idiopathic RBD

Nature and Science of Sleep, 2022
Si-Yi Gong,1,* Yun Shen,1,* Han-Ying Gu,1 Sheng Zhuang,1 Xiang Fu,1,2 Qiao-Jun Wang,1 Cheng-Jie Mao,1 Hua Hu,1 Yong-Ping Dai,1 Chun-Feng Liu1– 3 1Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated ...
Gong SY, Shen Y, Gu HY, Zhuang S, Fu X, Wang QJ, Mao CJ, Hu H, Dai YP, Liu CF   +9 more
doaj  

Molecular Mechanisms Driving Chemokine-mediated Prostate Myofibroblast Phenoconversion. [PDF]

, 2015
Benign prostate hyperplasia (BPH), a proliferative condition of the prostate common in aging in men, and smooth muscle hypercontractility are associated with urinary voiding dysfunction (LUTD) manifest as Lower Urinary Tract Symptoms (LUTS).
Rodriguez-Nieves, Jose Antonio
core   +3 more sources

Progression trajectories from prodromal to overt synucleinopathies: a longitudinal, multicentric brain [18F]FDG-PET study

npj Parkinson's Disease
The phenoconversion trajectory from idiopathic/isolated Rapid eye movement (REM) sleep behavior disorder (iRBD) towards either Parkinson’s Disease (PD) or Dementia with Lewy Bodies (DLB) is currently uncertain.
Beatrice Orso, Pietro Mattioli, Eun-Jin Yoon, Yu Kyeong Kim, Heejung Kim, Jung Hwan Shin, Ryul Kim, Francesco Famà, Andrea Brugnolo, Federico Massa, Agostino Chiaravalloti, Mariana Fernandes, Matteo Spanetta, Fabio Placidi, Matteo Pardini, Matteo Bauckneht, Silvia Morbelli, Jee-Young Lee, Claudio Liguori, Dario Arnaldi   +19 more
doaj   +1 more source

Illustrative and historic cases of phenoconversion.

American journal of translational research
Intersubject variability in drug response, whether related to efficacy or toxicity, is well recognized clinically. Over the years, drug selection from our pharmacologic armamentarium has moved from providers' preferred choices to more personalized treatments as clinicians' decisions are guided by data from clinical trials.
Veronique, Michaud, Pamela, Dow, Jacques, Turgeon   +2 more
openaire   +1 more source

CXCL12/CXCR4-Mediated Procollagen Secretion Is Coupled To Cullin-RING Ubiquitin Ligase Activation

Scientific Reports, 2018
Tissue fibrosis is mediated by the actions of multiple pro-fibrotic proteins that can induce myofibroblast phenoconversion through diverse signaling pathways coupled predominantly to Smads or MEK/Erk proteins.
Susan Patalano, José Rodríguez-Nieves, Cory Colaneri, Justin Cotellessa, Diego Almanza, Alisa Zhilin-Roth, Todd Riley, Jill Macoska   +7 more
doaj   +1 more source

Assessing user perspectives on clinical pharmacogenomics consultation documentation: a user-centered evaluation

Frontiers in Pharmacology
The University of Florida Health Precision Medicine Program plays a crucial role in delivering pharmacogenomics (PGx) result notes to providers who request PGx testing.
Nina Desai, Namratha Ravindra, Bradley Hall, Hana Al Alshaykh, Hana Al Alshaykh, Lauren Lemke, Eda Eken, Emily J. Cicali, Kristin Wiisanen, Larisa H. Cavallari, Khoa A. Nguyen   +10 more
doaj   +1 more source