Results 111 to 120 of about 3,015 (189)

Unravelling Voriconazole's Hepatic Metabolism: A Narrative Review on Factors Impacting Voriconazole‐N‐Oxide Exposure

Mycoses, Volume 69, Issue 2, February 2026.
ABSTRACT Background Voriconazole (VRC), a triazole antifungal agent, is recommended as primary treatment for invasive aspergillosis. Due to its unpredictable dose‐exposure relationship, therapeutic drug monitoring (TDM) is recommended. Despite TDM, the probability of achieving therapeutic targets is only approximately 50%.
Janne Hubrechts, Matthias Gijsen, Katelijne Floré, Veerle Grootaert, Florian Lemaitre, Christelle Boglione‐Kerrien, Beatrijs Mertens, Pieter Annaert, Katrien Lagrou, Isabel Spriet   +9 more
wiley   +1 more source

CXCL12/CXCR4-Mediated Procollagen Secretion Is Coupled To Cullin-RING Ubiquitin Ligase Activation

Scientific Reports, 2018
Tissue fibrosis is mediated by the actions of multiple pro-fibrotic proteins that can induce myofibroblast phenoconversion through diverse signaling pathways coupled predominantly to Smads or MEK/Erk proteins.
Susan Patalano, José Rodríguez-Nieves, Cory Colaneri, Justin Cotellessa, Diego Almanza, Alisa Zhilin-Roth, Todd Riley, Jill Macoska   +7 more
doaj   +1 more source

The Relevance of Integrating CYP2C19 Phenoconversion Effects into Clinical Pharmacogenetics

Pharmacopsychiatry
Abstract Introduction CYP2D6 and CYP2C19 functional status as defined by genotype is modulated by phenoconversion (PC) due to pharmacokinetic interactions. As of today, there is no data on the effect size of PC for CYP2C19 functional status.
Scherf-Clavel, Maike, Weber, Heike, Unterecker, Stefan, Frantz, Amelie, Eckert, Andreas, Reif, Andreas, Deckert, Jürgen, Hahn, Martina   +7 more
openaire   +2 more sources

Machine Learning Predicts Phenoconversion from Polysomnography in Isolated REM Sleep Behavior Disorder

Brain Sciences
Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is a prodromal stage of alpha-synucleinopathies. This study aimed at developing a fully-automated machine learning framework for the prediction of phenoconversion in patients with iRBD by ...
Matteo Cesari, Andrea Portscher, Ambra Stefani, Raphael Angerbauer, Abubaker Ibrahim, Elisabeth Brandauer, Simon Feuerstein, Kristin Egger, Birgit Högl, Antonio Rodriguez-Sanchez   +9 more
doaj   +1 more source

CYP3A-fenotype hos leddgiktpasienter i relasjon til inflammasjonsstatus og behandling med biologiske DMARDs [PDF]

, 2015
Bakgrunn: Enzymer tilhørende cytokrom P-450 3A (CYP3A)-subfamilien er de viktigste i metabolisme av legemidler. Systemisk inflammasjon er foreslått som en faktor til den store interindividuelle variabiliteten i CYP3A-fenotype, og 4β-hydroksykolesterol ...
Wollmann, Birgit Malene Tovik
core  

Case report: Therapeutic drug monitoring and CYP2D6 phenoconversion in a protracted paroxetine intoxication

Frontiers in Pharmacology
ObjectiveThe cytochrome P450 2D6 (CYP2D6) is an enzyme involved in the oxidative biotransformation of various widely used drugs, including paroxetine, a substrate and strong inhibitor of the enzyme.
Alena Damborská, Alena Damborská, Lenka Hanáková, Eva Pindurová, Eva Pindurová, Kateřina Horská, Kateřina Horská   +6 more
doaj   +1 more source

뇌파를 이용한 단독 렘수면행동장애의 시누클레인병증 발병 시기 및 아형 예측을 위한 기계 학습 모델 [PDF]

, 2023
학위논문(석사) -- 서울대학교대학원 : 공과대학 협동과정 바이오엔지니어링전공, 2023. 2. 정기영.Objective: Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal disease of α-synucleinopathies, and more than 80% of cases eventually convert to neurodegenerative diseases ...
정엘
core  

Accuracy of Rating Scales and Clinical Measures for Screening of Rapid Eye Movement Sleep Behavior Disorder and for Predicting Conversion to Parkinson’s Disease and Other Synucleinopathies

Frontiers in Neurology, 2018
Rapid eye movement (REM) sleep behavior disorder (RBD) is characterized by repeated episodes of REM sleep-related vocalizations and/or complex motor behaviors.
Matej Skorvanek, Matej Skorvanek, Eva Feketeova, Eva Feketeova, Monica M. Kurtis, Jan Rusz, Jan Rusz, Karel Sonka   +7 more
doaj   +1 more source

Illustrative and historic cases of phenoconversion.

American journal of translational research
Intersubject variability in drug response, whether related to efficacy or toxicity, is well recognized clinically. Over the years, drug selection from our pharmacologic armamentarium has moved from providers' preferred choices to more personalized treatments as clinicians' decisions are guided by data from clinical trials.
Veronique, Michaud, Pamela, Dow, Jacques, Turgeon   +2 more
openaire   +1 more source

The role of club cell phenoconversion and migration in idiopathic pulmonary fibrosis

Aging, 2016
Idiopathic pulmonary fibrosis (IPF) is an age-related multifactorial disease featuring non-uniform lung fibrosis. The decisive cellular events at early stages of IPF are poorly understood. While the involvement of club cells in IPF pathogenesis is unclear, their migration has been associated with lung fibrosis.
Fukumoto, Jutaro, Soundararajan, Ramani, Leung, Joseph, Cox, Ruan, Jr., Mahendrasah, Sanjay, Muthavarapu, Neha, Herrin, Travis, Czachor, Alexander, Tan, Lee C., Hosseinian, Nima, Patel, Priyanshi, Gone, Jayanthraj, Breitzig, Mason T., Cho, Young, Cooke, Andrew J., Galam, Lakshmi, Narala, Venkata Ramireddy, Pathak, Yashwant, Lockey, Richard F., Kolliputi, Narasaiah   +19 more
openaire   +3 more sources