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A cross-database bibliometric analysis of rapid eye movement sleep behavior disorder in Parkinson's disease research. [PDF]
Front Aging NeurosciDu S, Tian X, Ren R, Shi L.
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A Comprehensive Analysis Examining the Role of Genetic Influences on Psychotropic Medication Response in Children. [PDF]
Genes (Basel)Singh J +3 more
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Moving beyond muscle atonia: rapid eye movement sleep microstructure as a biomarker in sleep behavior disorder. [PDF]
SleepMogavero MP, Lanza G, Ferri R.
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CYP2D6 pharmacogenetics and phenoconversion in personalized medicine
Expert Opinion on Drug Metabolism and Toxicology, 2022CYP2D6 contributes to the metabolism of approximately 20-25% of drugs. However, CYP2D6 is highly polymorphic and different alleles can lead to impacts ranging from null to increase in activity. Moreover, there are commonly used drugs that potently inhibit the CYP2D6, thus causing 'phenoconversion' which can convert the genotypic normal metabolizer into
Julie A Johnson
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Addressing phenoconversion: the Achilles' heel of personalized medicine [PDF]
British Journal of Clinical Pharmacology, 2015 Phenoconversion is a phenomenon that converts genotypic extensive metabolizers (EMs) into phenotypic poor metabolizers (PMs) of drugs, thereby modifying their clinical response to that of genotypicPMs. Phenoconversion, usually resulting from nongenetic extrinsic factors, has a significant impact on the analysis and interpretation of genotype‐focused ...
Rashmi R Shāh, Robert Løvsletten Smith
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The theoretical problems of “prodrome” and “phenoconversion” in neurodegeneration
2023The recognition of and approach to prodromal symptoms, those which manifest before a diagnosis can be ascertained at the bedside, are of increasing interest in neurodegenerative research. A prodrome is conceived of as an early window into a disease, a critical time when putative disease-modifying interventions may be best suited for examination ...
Andrea, Sturchio, Alberto J, Espay
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How to Integrate CYP2D6 Phenoconversion Into Clinical Pharmacogenetics: A Tutorial
Clinical Pharmacology & Therapeutics, 2021CYP2D6 genotype is increasingly being integrated into practice to guide prescribing of certain medications. The CYP2D6 drug metabolizing enzyme is susceptible to inhibition by concomitant drugs, which can lead to a clinical phenotype that is different from the genotype‐based phenotype, a process referred to as phenoconversion. Phenoconversion is highly
Emily J, Cicali +9 more
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