Results 121 to 130 of about 3,015 (189)

Progression trajectories from prodromal to overt synucleinopathies: a longitudinal, multicentric brain [18F]FDG-PET study

npj Parkinson's Disease
The phenoconversion trajectory from idiopathic/isolated Rapid eye movement (REM) sleep behavior disorder (iRBD) towards either Parkinson’s Disease (PD) or Dementia with Lewy Bodies (DLB) is currently uncertain.
Beatrice Orso, Pietro Mattioli, Eun-Jin Yoon, Yu Kyeong Kim, Heejung Kim, Jung Hwan Shin, Ryul Kim, Francesco Famà, Andrea Brugnolo, Federico Massa, Agostino Chiaravalloti, Mariana Fernandes, Matteo Spanetta, Fabio Placidi, Matteo Pardini, Matteo Bauckneht, Silvia Morbelli, Jee-Young Lee, Claudio Liguori, Dario Arnaldi   +19 more
doaj   +1 more source

Insular monoaminergic deficits in prodromal α‐synucleinopathies

Annals of Clinical and Translational Neurology
Methods This study assessed data from two cohorts of patients with alpha‐synucleinopathies (University of Brescia and University of Rome Tor‐Vergata cohorts).
Andrea Pilotto, Alice Galli, Cinzia Zatti, Fabio Placidi, Francesca Izzi, Enrico Premi, Silvia P. Caminiti, Luca Presotto, Andrea Rizzardi, Marcello Catania, Alessandro Lupini, Leandro Purin, Maria P. Pasolini, Nicola B. Mercuri, Agostino Chiaravalotti, Mariana Fernandes, Carmen Calvello, Silvia Lucchini, Francesco Bertagna, Barbara Paghera, Daniela Perani, Daniela Berg, Alessandro Padovani, Claudio Liguori   +23 more
doaj   +1 more source

Bowel movement frequency and difficult defecation using constipation assessment scale in patients with isolated REM sleep behavior disorder

Clinical Parkinsonism & Related Disorders
Introduction: This study evaluated constipation, including reduced bowel movement frequency and difficult defecation, in patients with isolated rapid eye movement sleep behavior disorder (IRBD), which is prodromal Parkinson’s disease (PD) or dementia ...
Tomoyuki Miyamoto, Itsuo Nakajima, Takuo Arikawa, Masayuki Miyamoto   +3 more
doaj   +1 more source

Effect of CYP2D6, 2C19, and 3A4 Phenoconversion in Drug-Related Deaths

Toxics
Molecular autopsy is a very important tool in forensic toxicology. However, many determinants, such as co-medication and physiological parameters, should be considered for optimal results. These determinants could cause phenoconversion (PC), a discrepancy between the real metabolic profile after phenoconversion and the phenotype determined by the ...
Sanaa M. Aly, Benjamin Hennart, Jean-Michel Gaulier, Delphine Allorge   +3 more
openaire   +4 more sources

Blunted tachycardia and cardiac sympathetic denervation in isolated rapid eye movement sleep behavior disorder

BMC Neurology
Background Isolated rapid eye movement sleep behavior disorder (iRBD) serves as a prodromal phase of Parkinson’s disease (PD) and dementia with Lewy bodies (DLB).
Shota Saeda, Yukiyoshi Sumi, Koichi Fujiwara, Hiroshi Kadotani   +3 more
doaj   +1 more source

Editorial: Prodromal stage of neurodegenerative proteinopathies: from bench to bedside

Frontiers in Neuroscience, 2023
Bin Xu, Bin Xu, Seyed-Mohammad Fereshtehnejad, Seyed-Mohammad Fereshtehnejad, Yashar Zeighami, Yashar Zeighami   +5 more
doaj   +1 more source

Phenoconversion of CYP2C9 in epilepsy limits the predictive value of CYP2C9 genotype in optimizing valproate therapy [PDF]

, 2015
Bűdi, Tamás, Háfra, Edit, Kiss, Ádám, Monostory, Katalin, Temesvári, Manna, Tóth, Katalin   +5 more
core   +1 more source

Pharmacogenetic guided drug therapy – how to deal with phenoconversion in polypharmacy

Expert Opinion on Drug Metabolism & Toxicology
The prevalence of polypharmacy and the increasing availability of pharmacogenetic information in clinical practice have raised the prospect of data-driven clinical decision-making when addressing the issues of drug-drug interactions and genetic polymorphisms in metabolizing enzymes.
Julia Carolin Stingl, Roberto Viviani
openaire   +2 more sources

Gait Analysis with Wearable Sensors in Isolated REM Sleep Behavior Disorder Associated with Phenoconversion: An Explorative Study

Journal of Parkinson’s Disease
Background: Gait disturbance is a vital characteristic of motor manifestation in α – synucleinopathies, especially Parkinson’s disease. Subtle gait alterations are present in isolated rapid eye movement sleep behavior disorder (iRBD) patients before ...
Shanshan Cen, Hui Zhang, Yuan Li, Zhuqin Gu, Yuan Yuan, Zheng Ruan, Yanning Cai, Jagadish K. Chhetri, Shuying Liu, Wei Mao, Piu Chan   +10 more
doaj   +1 more source

Sex and age effects on prevalence of CYP2C19 and CYP2D6 Phenoconversion risk over time in patients with psychosis [PDF]

Pharmacogenetics in psychiatry may have benefits for medication treatment success. However, medication regimes leading to drug-drug interactions and potential phenoconversion of actionable pharmacogenetic phenotypes challenge the application of ...
De Brabander, Emma Y., Leibold, Nicole K., van Amelsvoort, Thérèse, van Westrhenen, Roos   +3 more
core   +1 more source