Results 141 to 150 of about 2,663 (168)

Safety and Efficacy of Idebenone in Isolated Rapid Eye Movement Sleep Behavior Disorder: A 3-Year Randomized Controlled Pilot Trial. [PDF]

Mov Disord
Li Y, Chen F, Luo N, Zhong M, Hu J, Yin Q, Ding Y, Niu M, Li B, Liu J.   +9 more
europepmc   +1 more source

Missing Funding/Support and Role of the Funder Statement.

JAMA Neurol
europepmc   +1 more source

Planning for prevention of Parkinson's and related synucleinopathies: A trial design forum (conference abstracts). [PDF]

J Parkinsons Dis
europepmc   +1 more source

Digital motor and cognitive variability as early markers of the prodromal Parkinson’s disease spectrum

Chohan H, Waters S, Pérez-Carbonell L, Leschziner G, Periñán M, Huxford B, Eriksson S, Bestwick J, Schrag A, Noyce A, Simonet C.   +10 more
europepmc   +1 more source

Phenoconversion of Cytochrome P450 Metabolism: A Systematic Review [PDF]

Journal of Clinical Medicine, 2020
Phenoconversion is the mismatch between the individual’s genotype-based prediction of drug metabolism and the true capacity to metabolize drugs due to nongenetic factors. While the concept of phenoconversion has been described in narrative reviews, no systematic review is available.
Sylvia D Klomp, Jesse J Swen, Martijn L Manson   +2 more
exaly   +8 more sources

Clinical Effects of CYP2D6 Phenoconversion in Patients With Psychosis

Journal of Psychopharmacology
Background: Pharmacogenetics is considered a promising avenue for improving treatment outcomes, yet evidence arguing for the use of pharmacogenetics in the treatment of psychotic disorders is mixed and clinical usefulness is under debate.
Emma Y de Brabander
exaly   +5 more sources

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CYP2D6 Pharmacogenetics and Phenoconversion in Personalized Medicine

Expert Opinion on Drug Metabolism and Toxicology, 2022
CYP2D6 contributes to the metabolism of approximately 20-25% of drugs. However, CYP2D6 is highly polymorphic and different alleles can lead to impacts ranging from null to increase in activity. Moreover, there are commonly used drugs that potently inhibit the CYP2D6, thus causing 'phenoconversion' which can convert the genotypic normal metabolizer into
Julie A Johnson
exaly   +3 more sources

Addressing Phenoconversion: The Achilles' Heel of Personalized Medicine [PDF]

British Journal of Clinical Pharmacology, 2015
Phenoconversion is a phenomenon that converts genotypic extensive metabolizers ( EM s) into phenotypic poor metabolizers ( PM s) of drugs, thereby modifying their clinical response to that of genotypic PM s ...
Robert Løvsletten Smith, Rashmi R Shah
exaly   +3 more sources

Derivation and Validation of a Phenoconversion-Related Pattern in Idiopathic Rapid Eye Movement Behavior Disorder [PDF]

Movement Disorders, 2023
Background: Idiopathic rapid eye movement sleep behavior disorder (iRBD) represents the prodromal stage of α-synucleinopathies. Reliable biomarkers are needed to predict phenoconversion.
Dario Arnaldi, Beatrice Orso, Pietro Mattioli   +2 more
exaly   +3 more sources