Results 131 to 140 of about 3,015 (189)

Motor features that distinguish isolated REM sleep behavior disorder patients from healthy controls: A systematic review

Journal of Parkinson’s Disease
Individuals with isolated REM sleep behavior disorder (iRBD) are at high risk of developing α-synucleinopathies, particularly Parkinson's disease (PD) and dementia with Lewy bodies (DLB).
Salma Elasfar, Hajr Hameed, Kaylena Ehgoetz Martens   +2 more
doaj   +1 more source

The utility of neuro-QOL in idiopathic REM sleep behavior disorder

Sleep Science and Practice
Introduction Idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) can affect quality of life (QOL) for both patient and bed partner; has been less well-studied.
Daniel A. Barone, Harini Sarva, Natalie Hellmers, Fei Wang, Zhenxing Xu, Ana C. Krieger, Claire Henchcliffe   +6 more
doaj   +1 more source

Huntington disease: natural history, biomarkers and prospects for therapeutics [PDF]

, 2014
Huntington disease (HD) can be seen as a model neurodegenerative disorder, in that it is caused by a single genetic mutation and is amenable to predictive genetic testing, with estimation of years to predicted onset, enabling the entire range of disease ...
Aylward, EH, Langbehn, DR, Leavitt, BR, Long, JD, Margolis, RL, Paulsen, JS, Reilmann, R, Ross, CA, Scahill, RI, Stout, JC, Tabrizi, SJ, Unschuld, PG, Warner, JH, Wexler, A, Wild, EJ   +14 more
core  

Imaging advances to detect non-motor prodromal markers of Parkinson’s disease and explore therapeutic translation opportunities

npj Parkinson's Disease
Parkinson’s disease (PD) is a progressive neurological disorder marked by late-emerging motor symptoms, but early non-motor signs like hyposmia and REM sleep behavior disorder may precede diagnosis by years.
Mathangi Palanivel, Krishna Kanta Ghosh, Madhav Mallam, Raghavan Bhuvanakantham, Parasuraman Padmanabhan, Kah-Leong Lim, Balázs Gulyás   +6 more
doaj   +1 more source

Validation of the REM behaviour disorder phenoconversion-related pattern in an independent cohort [PDF]

, 2023
Famà, F., Morbelli, S.
core   +1 more source

The Syn-sleep trial protocol: detection of cutaneous phosphorylated alpha-synuclein in REM sleep behavior disorder. [PDF]

Biomark Med
Marcotte S, Levine T, Freeman R, Gibbons CH.   +3 more
europepmc   +1 more source

Understanding variation in metoprolol response: CYP2D6, drug interactions, and phenoconversion

Metoprolol, a β1-selective blocker, is widely used for treating cardiovascular and non-cardiovascular conditions. Its pharmacokinetics (PK) and pharmacodynamics (PD) vary significantly between individuals, in part due to CYP2D6 genetic polymorphisms.
Azizi, Bayan, Lanfear, David E., Luzum, Jasmine A.   +2 more
openaire   +1 more source

Epigenetic ageing and the risk of Parkinson's disease. [PDF]

J Neurol Neurosurg Psychiatry
Peng X, Flores-Torres MH, Cortese M, Peng C, Hung AY, Schwarzschild M, Ascherio A, Bjornevik K.   +7 more
europepmc   +1 more source

Phenoconversion of Cytochrome P450 2D6

The Journal of Clinical Psychiatry, 2013
Berm, Elizabeth J J, Risselada, Arne J, Mulder, Hans, Hak, Eelko, Wilffert, Bob   +4 more
openaire   +4 more sources

The Miami Framework for ALS and related neurodegenerative disorders: an integrated view of phenotype and biology [PDF]

Increasing appreciation of the phenotypic and biological overlap between amyotrophic lateral sclerosis (ALS) and frontotemporal dementia, alongside evolving biomarker evidence for a pre-symptomatic stage of disease and observations that this stage of ...
Abrahams, Sharon, Al-Chalabi, Ammar, Andersen, Peter M, Arias, Jalayne J, Attendees of the Second International Pre-Symptomatic ALS Worksh, Benatar, Michael, Boeve, Bradley F, Boxer, Adam, Cai, Xueya, Cosentino, Stephanie, Crawley, Anita, Dacks, Penny, Dratch, Laynie, Houlden, Henry, Huey, Edward D, Lingor, Paul, McDermott, Michael P, McHutchison, Caroline, McMillan, Corey T, Petersen, Ronald C, Postuma, Ronald, Rosen, Howard, Shefner, Jeremy, Shneider, Neil, Thakur, Neil, Turner, Martin R, Wuu, Joanne   +26 more
core