Results 101 to 110 of about 3,015 (189)

Bacterial challenge-associated metabolic phenotypes in Hermetia illucens defining nutritional and functional benefits

Scientific Reports, 2021
Black soldier fly (BSF, Hermetia illucens) is popular for its applications in animal feed, waste management and antimicrobial peptide source. The major advantages of BSF larva include their robust immune system and high nutritional content that can be ...
Phuc N. Ho, Poramate Klanrit, Yupa Hanboonsong, Umaporn Yordpratum, Manida Suksawat, Thanaporn Kulthawatsiri, Anyarin Jirahiranpat, Suthicha Deewai, Panya Mackawan, Rasana W. Sermswan, Nisana Namwat, Watcharin Loilome, Tueanjit Khampitak, Arporn Wangwiwatsin, Jutarop Phetcharaburanin   +14 more
doaj   +1 more source

Impact of CYP2D6 Genotype and Inhibitor Use on Risperidone Metabolism in Children: Functional Insights Into the *17 and *29 Alleles

Clinical and Translational Science, Volume 19, Issue 3, March 2026.
ABSTRACT Risperidone, an atypical antipsychotic, is increasingly prescribed in pediatric patients with psychiatric disorders. It is primarily metabolized by CYP2D6 to 9‐hydroxyrisperidone, an active metabolite associated with a higher risk of adverse effects.
Matthew H. Bennett, Ethan A. Poweleit, Samuel E. Vaughn, Brandon Retke, Paul Toren, Jeffrey R. Strawn, Laura B. Ramsey   +6 more
wiley   +1 more source

Autophagy in phenoconversion of differentiated and undifferentiated fibroblasts

The FASEB Journal, 2013
Cardiac fibroblasts phenoconvert to hypersecretory myofibroblasts and deposit matrix resulting in cardiac fibrosis and autophagy that is associated to fibroproliferative events. Autophagy inhibition was studied in both primary (P0) rat cardiac fibroblasts (PF) and mouse embryonic fibroblasts (MEF).
Shivika Gupta, Morvarid Kavosh, Shu‐Ru Chen, Saeid Ghavami, Sunil Rattan, Thomas Klonisch, Ian Dixon   +6 more
openaire   +1 more source

Colloidal nanoparticles as advanced biological sensors

, 2014
Biological sensing using nanoparticles Colloidal fluorescent and plasmonic nanoparticles yield intense responses to incident light, making them useful as sensors or probes for sensitive detection in solution.
Chandrawati, R, Howes, PD, Stevens, MM
core   +1 more source

Abnormal metabolic network activity in REM sleep behavior disorder [PDF]

, 2014
OBJECTIVE: To determine whether the Parkinson disease-related covariance pattern (PDRP) expression is abnormally increased in idiopathic REM sleep behavior disorder (RBD) and whether increased baseline activity is associated with greater individual risk ...
+1 additional author, Dhawan, V., Eidelberg, D., Feigin, A., Gagnon, J. F., Holtbernd, F., Ma, Y., Montplaisir, J., Postuma, R. B., Soucy, J. P., Tang, C. C.   +10 more
core   +3 more sources

CYP2C19 genotype testing for clopidogrel: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

British Journal of Clinical Pharmacology, Volume 92, Issue 2, Page 329-347, February 2026.
Clopidogrel, an antiplatelet agent, is currently licensed in the United Kingdom for the prevention and treatment of atherothrombotic events in cerebrovascular disease, coronary artery disease and peripheral arterial disease. Clopidogrel requires metabolic activation by the cytochrome P450 enzyme CYP2C19 to be effective.
Cinzia Dello Russo, Iain Frater, Rebecca Kuruvilla, Stefanie Lip, Hannah O'Neill, Kerry Burke, Vicky Chaplin, Alexander S. F. Doney, Salim Elyas, Nicholas Greaves, Sophie Harding, David Hargroves, Judith Hayward, Dyfrig A. Hughes, Tom A. T. Hughes, Sree Kondapally, Patrick Mok, Aaron Peace, Imran Rafi, Simon Ray, Vicky Stinton, Luigi Venetucci, Munir Pirmohamed   +22 more
wiley   +1 more source

A protective role for N-acylphosphatidylethanolamine phospholipase D in 6-OHDA-induced neurodegeneration. [PDF]

, 2019
N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) catalyzes the cleavage of membrane NAPEs into bioactive fatty-acid ethanolamides (FAEs). Along with this precursor role, NAPEs might also serve autonomous signaling functions. Here, we report that
Palese, Francesca, Piomelli, Daniele, Pontis, Silvia, Realini, Natalia   +3 more
core  

How I manage luspatercept in transfusion‐dependent beta‐thalassemia

HemaSphere, Volume 10, Issue 2, February 2026.
Abstract Beta‐thalassemia is an inherited anemia characterized by a broad spectrum of clinical manifestations. The most severe form is transfusion‐dependent β‐thalassemia, in which patients need regular blood transfusions to survive, since no adequate amount of hemoglobin is produced by the bone marrow.
Daniele Lello Panzieri, Natalia Scaramellini, Simona Leoni, Ali Taher, Maria Domenica Cappellini, Irene Motta   +5 more
wiley   +1 more source

Using a Brief Body Sway Assessment Device to Track Balance Differences across the Huntington's Disease Integrated Staging System Spectrum

Movement Disorders Clinical Practice, Volume 13, Issue 2, Page 475-481, February 2026.
Abstract Background Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by a mutation in the huntingtin gene on chromosome 4, leading to progressive cognitive decline, motor impairment, and functional disability. Although balance impairment is recognized in HD, its onset and evolution with disease stage remain poorly ...
Japleen Kaur, Nadeen Youhanan, Krisha Bagga, Andrew Hall, Paul E. Gilbert, Daniel J. Goble, Jody Corey‐Bloom   +6 more
wiley   +1 more source

Assessing user perspectives on clinical pharmacogenomics consultation documentation: a user-centered evaluation

Frontiers in Pharmacology
The University of Florida Health Precision Medicine Program plays a crucial role in delivering pharmacogenomics (PGx) result notes to providers who request PGx testing.
Nina Desai, Namratha Ravindra, Bradley Hall, Hana Al Alshaykh, Hana Al Alshaykh, Lauren Lemke, Eda Eken, Emily J. Cicali, Kristin Wiisanen, Larisa H. Cavallari, Khoa A. Nguyen   +10 more
doaj   +1 more source