Results 101 to 110 of about 2,663 (168)

Case Report: Severe SIADH and QTc prolongation induced by escitalopram-quetiapine interaction in a CYP2C19 intermediate metabolizer at therapeutic doses

Frontiers in Pharmacology
Escitalopram is widely regarded as a well-tolerated selective serotonin reuptake inhibitor (SSRI) with a favorable safety profile. However, severe adverse events can occur even at therapeutic doses in susceptible individuals.
Zongchen Jiang, Xiaoyu Qu, Zimin Yan, Jungang Fang, Jin Lan, Xin Zhao, Wensheng Qi   +6 more
doaj   +1 more source

Effect of CYP2D6, 2C19, and 3A4 Phenoconversion in Drug-Related Deaths

Toxics
Molecular autopsy is a very important tool in forensic toxicology. However, many determinants, such as co-medication and physiological parameters, should be considered for optimal results. These determinants could cause phenoconversion (PC), a discrepancy between the real metabolic profile after phenoconversion and the phenotype determined by the ...
Sanaa M. Aly, Benjamin Hennart, Jean-Michel Gaulier, Delphine Allorge   +3 more
openaire   +4 more sources

The potential role of large language models in addressing phenoconversion in pharmacogenomics

Frontiers in Genetics
Pharmacogenomics (PGx) is a cornerstone of precision medicine, enabling individualized drug therapy by identifying genetic factors that influence drug disposition and response.
Augusto García-Agúndez, José A. G. Agúndez   +1 more
doaj   +1 more source

Editorial: Prodromal stage of neurodegenerative proteinopathies: from bench to bedside

Frontiers in Neuroscience, 2023
Bin Xu, Bin Xu, Seyed-Mohammad Fereshtehnejad, Seyed-Mohammad Fereshtehnejad, Yashar Zeighami, Yashar Zeighami   +5 more
doaj   +1 more source

Association of Cardiovascular Autonomic Failure With Progression and Phenoconversion in Isolated REM Sleep Behavior Disorder [PDF]

Background and objectives: Isolated REM sleep behavior disorder (iRBD) is a prodromal state of α-synucleinopathies, presenting years before overt neurodegenerative disorders.
Barletta, Giorgio, Provini, Federica, Cecere, Annagrazia, Loddo, Giuseppe, Sambati, Luisa, Mainieri, Greta, Giannini, Giulia, Guaraldi, Pietro, Baldelli, Luca, Cortelli, Pietro, Mignani, Francesco, Calandra-Buonaura, Giovanna, Di Laudo, Felice   +12 more
core   +1 more source

Insular monoaminergic deficits in prodromal α‐synucleinopathies

Annals of Clinical and Translational Neurology
Methods This study assessed data from two cohorts of patients with alpha‐synucleinopathies (University of Brescia and University of Rome Tor‐Vergata cohorts).
Andrea Pilotto, Alice Galli, Cinzia Zatti, Fabio Placidi, Francesca Izzi, Enrico Premi, Silvia P. Caminiti, Luca Presotto, Andrea Rizzardi, Marcello Catania, Alessandro Lupini, Leandro Purin, Maria P. Pasolini, Nicola B. Mercuri, Agostino Chiaravalotti, Mariana Fernandes, Carmen Calvello, Silvia Lucchini, Francesco Bertagna, Barbara Paghera, Daniela Perani, Daniela Berg, Alessandro Padovani, Claudio Liguori   +23 more
doaj   +1 more source

Blunted tachycardia and cardiac sympathetic denervation in isolated rapid eye movement sleep behavior disorder

BMC Neurology
Background Isolated rapid eye movement sleep behavior disorder (iRBD) serves as a prodromal phase of Parkinson’s disease (PD) and dementia with Lewy bodies (DLB).
Shota Saeda, Yukiyoshi Sumi, Koichi Fujiwara, Hiroshi Kadotani   +3 more
doaj   +1 more source

Visuospatial dysfunction predicts dementia-first phenoconversion in isolated REM sleep behaviour disorder

Objective: While isolated rapid eye movement sleep behaviour disorder (iRBD) is known as a prodrome of α-synucleinopathies, the prediction for its future phenoconversion to parkinsonism-first or dementia-first subtype remains a challenge.
Chan, Joey WY, Mok, Vincent, Zhou, Li, Wing, Yun Kwok, Liu, Yaping, Tang, Shi, Huang, Bei, Feng, Hongliang, Li, Shirley X, Wang, Jing, Chau, Steven WH, Zhang, Jihui   +11 more
core   +1 more source

Motor features that distinguish isolated REM sleep behavior disorder patients from healthy controls: A systematic review

Journal of Parkinson’s Disease
Individuals with isolated REM sleep behavior disorder (iRBD) are at high risk of developing α-synucleinopathies, particularly Parkinson's disease (PD) and dementia with Lewy bodies (DLB).
Salma Elasfar, Hajr Hameed, Kaylena Ehgoetz Martens   +2 more
doaj   +1 more source

Gait Analysis with Wearable Sensors in Isolated REM Sleep Behavior Disorder Associated with Phenoconversion: An Explorative Study

Journal of Parkinson’s Disease
Background: Gait disturbance is a vital characteristic of motor manifestation in α – synucleinopathies, especially Parkinson’s disease. Subtle gait alterations are present in isolated rapid eye movement sleep behavior disorder (iRBD) patients before ...
Shanshan Cen, Hui Zhang, Yuan Li, Zhuqin Gu, Yuan Yuan, Zheng Ruan, Yanning Cai, Jagadish K. Chhetri, Shuying Liu, Wei Mao, Piu Chan   +10 more
doaj   +1 more source